FYCO1

The gene encodes a Rab7 adapter protein that is implicated in the microtubule transport of autophagosomes. The encoded protein contains a RUN domain, a FYVE-type zinc finger domain, and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P), the autophagosome marker LC3, and the kinesin KIF5. Mutations in this gene are associated with inclusion body myositis (IBM) and autosomal recessive congenital cataracts (CATC2). [provided by RefSeq, Aug 2020]

Description

FYVE and coiled-coil domain autophagy adaptor 1

Tissue specificity

Tissue enhanced (skeletal muscle)

Subcell location

Vesicles

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (45917899 - 45995824)

Ensembl ID

ENSG00000163820  (ver. 103.38)

Orthologs

Mouse Fyco1: ENSMUSG00000025241

UniProt

Q9BQS8

neXtProt

NX_Q9BQS8

Human splice variants
Mouse splice variants

Protein structure