Tissue expression
Cell line expression
Protein structure
WRN
WRN RecQ like helicaseRECQ3, RECQL2
This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
Top validated antibodies |
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Novus Biologicals | NB100-471 | 10 references | Polyclonal |
WB
ICC
IP
IHC
ChIP
|
|
antibodies-online | ABIN394233 | 5 references | Monoclonal |
WB
EL
ICC
IHC |
|
GeneTex | GTX101081 | 2 references | Polyclonal |
WB
ICC
IP
IHC |
|
Invitrogen Antibodies | PA5-27319 | 1 references | Polyclonal |
WB
ICC
IP
IHC |
|
Affinity Biosciences | DF8369 | Polyclonal |
WB
EL
ICC
IHC |
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Recommended by provider