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Cell line expression
Protein structure
BCL2L1
BCL2 like 1Bcl-X, bcl-xL, bcl-xS, BCL2L, BCLX, PPP1R52
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
Top validated antibodies |
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| Proteintech Group |  10783-1-AP |
112 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Invitrogen Antibodies | MA5-11950 |
14 references | Monoclonal |
ICC
IHC
FC
OA
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| Novus Biologicals | NBP1-28559 |
1 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
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| GeneTex | GTX105661 |
9 references | Polyclonal |
WB
ICC
IP
IHC
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| Cell Signaling Technology, Inc | 2764 |
3 references | Monoclonal |
WB
ICC
IP
IHC
FC
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