Tissue expression
Cell line expression
Protein structure
MTOR
Mechanistic target of rapamycin kinaseFLJ44809, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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GeneTex | GTX101557 | 9 references | Polyclonal |
WB
ICC
IP
IHC
ChIP
|
|
Invitrogen Antibodies | PA5-34663 | 10 references | Polyclonal |
WB
ICC
IP
IHC
ChIP
OA |
|
Boster Biological Technology | M00003 | 27 references | Monoclonal |
WB
ICC
IP
IHC
FC
|
|
Proteintech Group | 66888-1-Ig | 62 references | Monoclonal |
WB
EL
ICC
IP
IHC
|
|
Novus Biologicals | NB100-240 | 7 references | Polyclonal |
WB
ICC
IP
IHC |
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Supportive data in Antibodypedia
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Recommended by provider