PKN1

gene product

DBK, MGC46204, PAK1, PKN, PRK1, PRKCL1

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Ensembl	UniProt	RefSeq	Entrez
ENST00000242783 ENSP00000242783	PKN1_HUMAN Q16512	NP_002732.3 NP_002732	PKN1 5585
ENST00000342216 ENSP00000343325	PKN1_HUMAN Q16512	NP_998725.1 NP_998725	PKN1 5585
ENST00000585619 ENSP00000467422			PKN1 5585
ENST00000586237 ENSP00000466819			PKN1 5585
ENST00000586557 ENSP00000465842			PKN1 5585
ENST00000590097 ENSP00000466367			PKN1 5585
ENST00000591461 ENSP00000465867			PKN1 5585
ENST00000592960 ENSP00000468497			PKN1 5585

Ensembl	UniProt	RefSeq	Entrez
ENSMUST00000005616 ENSMUSP00000005616	PKN1_MOUSE P70268	NP_796236.2 NP_796236	Pkn1 320795
ENSMUST00000132945 ENSMUSP00000115054	D6RH37		Pkn1 320795
ENSMUST00000144258 ENSMUSP00000116235	PKN1_MOUSE P70268	NP_001186522.1 NP_001186522	Pkn1 320795

More gene data

Featured antibodies

Thermo Fisher Scientific Pierce

PA5-15128

0 references

Polyclonal

Western blot - Supportive data in Antibodypedia

Immunohistochemistry - Supportive data in Antibodypedia

Flow cytometry - Recommended by provider

Antibodies

Supportive data in Antibodypedia

Data presented on provider website

Data in Antibodypedia (inconclusive)

Recommended by provider

50 antibodies from 14 providers.

Show Additional Columns

	Antibody	Refs	Type
Abnova Corporation 8 antibodies
	H00005585-M01		Monoclonal
	PAB2308	1	Polyclonal
	PAB2310	1	Polyclonal
	H00005585-D01		Polyclonal
	H00005585-B01P		Polyclonal
	H00005585-D01P		Polyclonal
	H00005585-M02		Monoclonal
	PAB0271		Polyclonal
Novus Biologicals 6 antibodies
	H00005585-M01		Monoclonal
	NBP1-85301		Polyclonal
	H00005585-B01P		Polyclonal
	H00005585-D01P		Polyclonal
	H00005585-M02		Monoclonal
	H00005585-D01		Polyclonal
GeneTex 4 antibodies
	GTX62733		Monoclonal
	GTX62093		Monoclonal
	GTX104094		Polyclonal
	GTX111486		Polyclonal
Acris Antibodies GmbH 5 antibodies
	AP14816PU-N		Polyclonal
	AP14818PU-N		Polyclonal
	AP22118SU-S		Polyclonal
	AP14816CP-N		Polyclonal
	AP14818CP-N		Polyclonal
Thermo Fisher Scientific Pierce 2 antibodies
	PA5-15128		Polyclonal
	PA5-15130		Polyclonal
Atlas Antibodies 1 antibody
	HPA003982		Polyclonal
antibodies-online 1 antibody
	ABIN392447		Polyclonal
Cell Signaling Technology, Inc 1 antibody
	2611	1	Polyclonal
Epitomics 2 antibodies
	2662-1		Monoclonal
	2522-1		Monoclonal
Creative Biomart 8 antibodies
	CABT-38846RH		Monoclonal
	CABT-17787MH		Monoclonal
	CAB-4216RH		Monoclonal
	CABT-17788MH		Monoclonal
	CABT-38845RH		Monoclonal
	CABT-26820MH		Monoclonal
	CPBT-41316MH		Polyclonal
	CPBT-56538RH		Polyclonal
Santa Cruz Biotechnology 1 antibody
	sc-7161		Polyclonal
LifeSpan BioSciences, Inc. 7 antibodies
	LS-C99727		Polyclonal
	LS-C99729		Polyclonal
	LS-B1293		Polyclonal
	LS-B3357		Polyclonal (Antigen purified)
	LS-C105474		Monoclonal
	LS-C17471		Polyclonal
	LS-C17472		Polyclonal
Sigma-Aldrich 3 antibodies
	HPA003982		Polyclonal
	WH0005585M1		Monoclonal
	K1642		Polyclonal
EMD Millipore 1 antibody
	07-557		Polyclonal

PKN1

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