KIT

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Protein family

CD markers, Enzymes, Kinases, Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP

Chromosome

4:q12 (55524085 - 55606881)

Ensembl ID

ENSG00000157404  (ver. 69.37)

Orthologs

Mouse Kit: ENSMUSG00000005672

Human splice variants
Mouse splice variants