ALDH3A1

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

Description

aldehyde dehydrogenase 3 family, member A1

Protein family

Enzymes

Chromosome

17:p11.2 (19641297 - 19652256)

Ensembl ID

ENSG00000108602  (ver. 69.37)

Orthologs

Mouse Aldh3a1: ENSMUSG00000019102

Human splice variants
Mouse splice variants