ABCE1

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Description

ATP-binding cassette, sub-family E (OABP), member 1

Protein family

-

Chromosome

4:q31.21 (146019084 - 146050331)

Ensembl ID

ENSG00000164163  (ver. 69.37)

Orthologs

Mouse Abce1: ENSMUSG00000058355

Human splice variants
Mouse splice variants