ACSL5

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

acyl-CoA synthetase long-chain family member 5

Protein family

Enzymes, Membrane proteins predicted by MDM

Chromosome

10:q25.2 (114133776 - 114188138)

Ensembl ID

ENSG00000197142  (ver. 69.37)

Orthologs

Mouse Acsl5: ENSMUSG00000024981

Human splice variants
Mouse splice variants