KLK6

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Description

kallikrein-related peptidase 6

Protein family

Candidate cancer biomarkers, Mapped to UniProt SWISS-PROT, Peptidases, Plasma proteins, Potential transmembrane proteins, Potentially secreted proteins

Chromosome

19:q13.41 (51461887 - 51472929)

Ensembl ID

ENSG00000167755  (ver. 71.37)

Orthologs

Mouse Klk6: ENSMUSG00000050063

Human splice variants
Mouse splice variants