VRK1

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]

Description

vaccinia related kinase 1

Protein family

Enzymes, Kinases, Membrane proteins predicted by MDM

Chromosome

14:q32.2 (97263641 - 97398059)

Ensembl ID

ENSG00000100749  (ver. 69.37)

Orthologs

Mouse Vrk1: ENSMUSG00000021115

Human splice variants
Mouse splice variants