F2RL1

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]

Description

coagulation factor II (thrombin) receptor-like 1

Protein family

GPCRs excl olfactory receptors, Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP

Chromosome

5:q13.3 (76114758 - 76131140)

Ensembl ID

ENSG00000164251  (ver. 69.37)

Orthologs

Mouse F2rl1: ENSMUSG00000021678

Human splice variants
Mouse splice variants