METAP2

This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Jul 2008]

Description

methionyl aminopeptidase 2

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Peptidases, Potentially secreted proteins

Chromosome

12:q22 (95867296 - 95909615)

Ensembl ID

ENSG00000111142  (ver. 71.37)

Orthologs

Mouse Metap2: ENSMUSG00000036112

Human splice variants
Mouse splice variants