CALR

gene product
cC1qR, CRT, FLJ26680, RO, SSA
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]
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465 antibodies from 28 providers.

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AntibodyRefsTypeKDWBELICCIPIHCFC
Novus Biologicals
12 antibodies
Thermo Fisher Scientific Pierce
13 antibodies
antibodies-online
172 antibodies
Enzo Life Sciences
15 antibodies
Abnova Corporation
7 antibodies
GeneTex
11 antibodies
OriGene
14 antibodies
Aviva Systems Biology
9 antibodies
Biorbyt
44 antibodies
Acris Antibodies GmbH
17 antibodies
Bioworld Technology, Inc
2 antibodies
Abgent
6 antibodies
R&D Systems
5 antibodies
Proteintech Group
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
LifeSpan BioSciences, Inc.
73 antibodies
Atlas Antibodies
1 antibody
Bethyl Laboratories, Inc.
6 antibodies
Cell Signaling Technology, Inc
2 antibodies
RabMAbs
4 antibodies
RayBiotech, Inc.
5 antibodies
Creative Diagnostics
8 antibodies
EMD Millipore
3 antibodies
Sigma-Aldrich
7 antibodies
United States Biological
10 antibodies
Abbiotec
2 antibodies
GenWay
2 antibodies