Tissue expression
Cell line expression
Protein structure
HDAC8
Histone deacetylase 8HDACL1, KDAC8, MRXS6, RPD3, WTS
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Top validated antibodies |
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Proteintech Group | ![]() |
21 references | Polyclonal |
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LSBio | ![]() |
Polyclonal |
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Novus Biologicals | ![]() |
Monoclonal |
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GeneTex | ![]() |
1 references | Polyclonal |
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Boster Biological Technology | ![]() |
Polyclonal |
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