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PDE6A
Phosphodiesterase 6APDEA, RP43
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  21200-1-AP |
5 references | Polyclonal |
WB
EL
ICC
IHC
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| NSJ Bioreagents | RQ5909 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Boster Biological Technology | A07800-1 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Atlas Antibodies | HPA016970 |
1 references | Polyclonal |
WB
IHC
|
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| Novus Biologicals | NBP1-87312 |
3 references | Polyclonal |
WB
IHC
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