ARID2

This gene encodes a member of the AT-rich interactive domain (ARID)-containing family of DNA-binding proteins. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and chromatin structure modification. This protein functions as a subunit of the polybromo- and BRG1-associated factor or PBAF (SWI/SNF-B) chromatin remodeling complex which facilitates ligand-dependent transcriptional activation by nuclear receptors. Mutations in this gene are associated with hepatocellular carcinomas. A pseudogene of this gene is found on chromosome1. [provided by RefSeq, Dec 2016]

Description

AT-rich interaction domain 2

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Plasma membrane

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

12 (45729706 - 45908040)

Ensembl ID

ENSG00000189079  (ver. 103.38)

Orthologs

Mouse Arid2: ENSMUSG00000033237

UniProt

Q68CP9

neXtProt

NX_Q68CP9

Human splice variants
Mouse splice variants

Protein structure