SIPA1

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]

Description

Signal-induced proliferation-associated 1

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Nucleoplasm, Nucleoli, Golgi apparatus, Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (65638101 - 65650918)

Ensembl ID

ENSG00000213445  (ver. 103.38)

Orthologs

Mouse Sipa1: ENSMUSG00000056917

UniProt

Q96FS4

neXtProt

NX_Q96FS4

Human splice variants
Mouse splice variants

Protein structure