SH2D1A

gene product
DSHP, EBVS, IMD5, LYP, MTCP1, SAP, XLP, XLPD
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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282 antibodies from 29 providers.

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AntibodyRefsTypeKDWBELICCIPIHCFC
Abnova Corporation
7 antibodies
antibodies-online
89 antibodies
Novus Biologicals
9 antibodies
GeneTex
4 antibodies
OriGene
5 antibodies
Biorbyt
11 antibodies
LifeSpan BioSciences, Inc.
24 antibodies
Bioworld Technology, Inc
2 antibodies
Proteintech Group
1 antibody
Cell Signaling Technology, Inc
3 antibodies
NSJ Bioreagents
2 antibodies
NovoPro Bioscience Inc.
4 antibodies
Arigo
2 antibodies
Everest Biotech
2 antibodies
Acris Antibodies GmbH
5 antibodies
RabMAbs
2 antibodies
Aviva Systems Biology
6 antibodies
Invitrogen Antibodies
3 antibodies
R&D Systems
2 antibodies
Abgent
2 antibodies
SignalChem
1 antibody
United States Biological
70 antibodies
MyBioSource
7 antibodies
St John's Laboratory
1 antibody
EMD Millipore
1 antibody
Exalpha Biologicals, Inc.
1 antibody
Sigma-Aldrich
3 antibodies
Sino Biological Inc.
1 antibody