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Protein structure
SH2D1A
SH2 domain containing 1ADSHP, EBVS, IMD5, LYP, MTCP1, SAP, XLP, XLPD
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Novus Biologicals |  H00004068-M01 |
7 references | Monoclonal |
WB
EL
FC
FA
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| LSBio | LS-C389220 |
Polyclonal |
WB
EL
IHC
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| antibodies-online | ABIN561703 |
5 references | Monoclonal |
WB
EL
|
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| Abnova Corporation | H00004068-M01 |
5 references | Monoclonal |
WB
EL
|
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| Invitrogen Antibodies | 14-9888-82 |
3 references | Monoclonal |
WB
OA
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