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LearnTissue expression
Cell line expression
Protein structure
TSC1
TSC complex subunit 1hamartin, KIAA0243, LAM, TSC
This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018]
Top validated antibodies |
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| Proteintech Group |  20988-1-AP |
10 references | Polyclonal |
WB
EL
ICC
IHC
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| LSBio | LS-C801254 |
Polyclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | PA5-116079 |
Polyclonal |
WB
ICC
IP
IHC
OA
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| NSJ Bioreagents | RQ7757 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Novus Biologicals | NB100-2821 |
4 references | Polyclonal |
WB
EL
IHC
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