Tissue expression
Cell line expression
Protein structure
EIF2S1
Eukaryotic translation initiation factor 2 subunit alphaEIF-2alpha, EIF2, EIF2A
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]). [supplied by OMIM, Feb 2010]
Top validated antibodies |
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Proteintech Group | ![]() |
68 references | Polyclonal |
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Invitrogen Antibodies | ![]() |
20 references | Monoclonal |
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antibodies-online | ![]() |
5 references | Monoclonal |
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Novus Biologicals | ![]() |
1 references | Monoclonal |
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LSBio | ![]() |
Monoclonal |
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