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Cell line expression
Protein structure
COL4A1
Collagen type IV alpha 1 chainThis gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Top validated antibodies |
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| Novus Biologicals |  NB120-6586 |
17 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| GeneTex | GTX26311 |
4 references | Monoclonal |
WB
EL
ICC
IHC
IEM
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| OriGene | R1041B |
1 references | Polyclonal |
WB
EL
IP
IHC
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| antibodies-online | ABIN267585 |
8 references | Polyclonal |
WB
EL
IP
IHC
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| Biorbyt | orb867276 |
Other |
WB
EL
ICC
IHC
RA
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