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IL2RA
Interleukin 2 receptor subunit alphaCD25, IDDM10, IL2R
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020]
Top validated antibodies |
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| Novus Biologicals |  NB100-64761 |
8 references | Monoclonal |
EL
ICC
IP
IHC
FC
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| antibodies-online | ABIN1724861 |
2 references | Monoclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | M10AR |
2 references | Monoclonal |
WB
ICC
IP
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FC
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| R&D Systems | MAB623-100 |
2 references | Monoclonal |
WB
EL
ICC
IHC
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| GeneTex | GTX15757 |
Monoclonal |
WB
ICC
IP
IHC
FC
|
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