CD40

gene product
Bp50, p50, TNFRSF5
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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936 antibodies from 24 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
306 antibodies
R&D Systems
6 antibodies
Novus Biologicals
90 antibodies
Aviva Systems Biology
29 antibodies
Acris Antibodies GmbH
52 antibodies
Abnova Corporation
48 antibodies
BioLegend
41 antibodies
GeneTex
28 antibodies
Thermo Fisher Scientific Pierce
16 antibodies
Atlas Antibodies
3 antibodies
Creative Biomart
140 antibodies
LifeSpan BioSciences, Inc.
97 antibodies
Proteintech Group
1 antibody
Boster Immunoleader Biotechnology
2 antibodies
Spring Bioscience
4 antibodies
GenWay
19 antibodies
RayBiotech, Inc.
6 antibodies
United States Biological
13 antibodies
eBioscience, An Affymetrix Company
17 antibodies
Abbiotec
5 antibodies
Covance
1 antibody
RabMAbs
1 antibody
Enzo Life Sciences
7 antibodies
Sigma-Aldrich
4 antibodies