LRP1

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

Description

LDL receptor related protein 1

Tissue specificity

Tissue enhanced (adipose tissue)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular, Membrane

Protein family

Candidate cardiovascular disease genes
CD markers
Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

12 (57128483 - 57213361)

Ensembl ID

ENSG00000123384  (ver. 103.38)

Orthologs

Mouse Lrp1: ENSMUSG00000040249

UniProt

Q07954

neXtProt

NX_Q07954

Human splice variants
Mouse splice variants

Protein structure