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Protein structure
SMAD7
SMAD family member 7MADH7, MADH8
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Top validated antibodies |
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| Invitrogen Antibodies |  42-0400 |
10 references | Polyclonal |
WB
ICC
IHC
FC
OA
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| Novus Biologicals | NBP2-24710 |
11 references | Polyclonal |
WB
EL
IP
IHC
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| Proteintech Group | 25840-1-AP |
95 references | Polyclonal |
WB
EL
IHC
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| LSBio | LS-C832606 |
Polyclonal |
WB
EL
IHC
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| R&D Systems | MAB2029 |
23 references | Monoclonal |
WB
IHC
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