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Cell line expression
Protein structure
IL21R
Interleukin 21 receptorCD360
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
Top validated antibodies |
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| Invitrogen Antibodies |  10533-1-AP |
Polyclonal |
WB
ICC
IP
IHC
FC
OA
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| Proteintech Group | 10533-1-AP |
1 references | Polyclonal |
WB
EL
ICC
IHC
FC
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| Novus Biologicals | NBP1-76739 |
2 references | Polyclonal |
WB
EL
ICC
IHC
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| NovoPro Bioscience Inc. | 111778 |
Polyclonal |
WB
EL
IP
IHC
FC
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| GeneTex | GTX31270 |
Polyclonal |
WB
EL
ICC
IHC
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