Tissue expression
Cell line expression
Protein structure
COL4A1
Collagen type IV alpha 1 chainThis gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Top validated antibodies |
|||||
Novus Biologicals | NB120-6586 | 17 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
GeneTex | GTX26311 | 4 references | Monoclonal |
WB
EL
ICC
IHC
IEM
|
|
Boster Biological Technology | PB9099 | 19 references | Polyclonal |
WB
ICC
IHC
|
|
OriGene | R1041B | 1 references | Polyclonal |
WB
EL
IP
IHC |
|
antibodies-online | ABIN267585 | 8 references | Polyclonal |
WB
EL
IP
IHC |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider