MMP3

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

Description

matrix metallopeptidase 3 (stromelysin 1, progelatinase)

Protein family

Enzymes, Peptidases, Secreted proteins predicted by MDSP

Chromosome

11:q22.2 (102706532 - 102714534)

Ensembl ID

ENSG00000149968  (ver. 69.37)

Orthologs

Mouse Mmp3: ENSMUSG00000043613

Human splice variants
Mouse splice variants