STIM1

This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. [provided by RefSeq, Jan 2009]

Description

stromal interaction molecule 1

Protein family

Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP, Transporters

Chromosome

11:p15.4 (3875757 - 4114439)

Ensembl ID

ENSG00000167323  (ver. 69.37)

Orthologs

Mouse Stim1: ENSMUSG00000030987

Human splice variants
Mouse splice variants