SHC1

gene product
p66, SHC
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Reference

Provider

Host

Reactivity

Antibody type

  or   Clear
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
224 antibodies from 23 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeWBELIFIPIHFC
Santa Cruz Biotechnology
2 antibodies
sc-9676Monoclonal
sc-2882Polyclonal (Antigen purified)
Abnova Corporation
7 antibodies
H00006464-M01Monoclonal
MAB08071Monoclonal
Acris Antibodies GmbH
28 antibodies
AM20940PU-NMonoclonal
AP02542PU-NPolyclonal
GeneTex
18 antibodies
GTX101050Polyclonal
GTX50326Polyclonal
Novus Biologicals
17 antibodies
H00006464-M01Monoclonal
NBP2-02452Monoclonal
OriGene
4 antibodies
TA501056Monoclonal
TA501074Monoclonal
Thermo Fisher Scientific Pierce
5 antibodies
PA5-27310Polyclonal
PA5-14860Polyclonal
Bethyl Laboratories, Inc.
3 antibodies
A302-020APolyclonal
A302-019APolyclonal
antibodies-online
53 antibodies
ABIN3921801Polyclonal
ABIN396022Monoclonal
Proteintech Group
2 antibodies
10054-1-APPolyclonal
12496-1-APPolyclonal
Enzo Life Sciences
5 antibodies
ADI-905-665-100Monoclonal
ALX-210-535-R100Polyclonal
Aviva Systems Biology
5 antibodies
OAAB04812Polyclonal
OAAB04810Polyclonal
Cell Signaling Technology, Inc
3 antibodies
24311Polyclonal
24341Polyclonal
Boster Immunoleader Biotechnology
1 antibody
PA1897Polyclonal
Creative Biomart
23 antibodies
CAB-7211MHMonoclonal
CABT-16100MHMonoclonal
LifeSpan BioSciences, Inc.
27 antibodies
LS-B4416Monoclonal
LS-C10121Monoclonal
Epitomics
3 antibodies
1629-1Monoclonal
2196-1Monoclonal
Atlas Antibodies
1 antibody
HPA001844Polyclonal
Abiocode, Inc.
2 antibodies
R0535-5Polyclonal
R0535-7Polyclonal
EMD Millipore
4 antibodies
06-203Polyclonal
07-209Polyclonal
Sigma-Aldrich
4 antibodies
WH0006464M1Monoclonal
HPA001844Polyclonal
BioLegend
1 antibody
615202Polyclonal
GenWay
6 antibodies
18-272-196235Polyclonal
18-272-197393Polyclonal