PEDS1-UBE2V1

The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]

Description

PEDS1-UBE2V1 readthrough

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm

Predicted location

Membrane

Protein family

Predicted membrane proteins

Chromosome

20 (50081124 - 50153637)

Ensembl ID

ENSG00000124208  (ver. 103.38)

Orthologs

Mouse Gm20431: ENSMUSG00000089739

UniProt

 

neXtProt

 

Human splice variants
Mouse splice variants

Protein structure