16-7129-81

antibody from Invitrogen Antibodies
Targeting: IL23A IL-23, IL-23A, IL23P19, P19, SGRF
Provider product page for 16-7129-81
ELISA
Blocking/Neutralizing
Other assay

Antibody data

Product number
16-7129-81 - Provider product page
Provider
Invitrogen Antibodies
Product name
IL-12/IL-23 p40 Monoclonal Antibody (C8.6), Functional Grade, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: The C8.6 antibody reacts with the p40 subunit of human IL-12 p70 and human IL-23. IL-12 is a 70 kDa heterodimeric cytokine composed of two covalently linked chains, p40 and p35, and secreted primarily by activated monocytes, macrophages, and dendritic cells. IL-23 is a biologically-related, heterodimeric cytokine composed of disulfide-linked p40 and p19 subunits. Applications Reported: The C8.6 antibody has been reported for use ELISA, ELISPOTand neutralization. Applications Tested: The Functional Grade Purified C8.6 antibody has been tested by LAL assay to verify low endotoxin levels and has been tested for ELISA detection and in bioassay for neutralization of IL-12 p70 and IL-23 bioactivity. The C8.6 antibody at 60.0 ng/mL has been found to inhibit by 50% the biological effects of 1 ng/mL human IL-12 p70 (14-8129) or human IL-23 (14-8239), in corresponding bioassay. Detailed information and protocols about cytokine bioassays and in vitro cytokine neutralization using antibodies can be found in the BestProtocols® section. Storage and handling: Use in a sterile environment. Filtration: 0.2 µm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC.
Reactivity
Human
Host
Mouse
Isotype
IgG
Antibody clone number
C8.6
Vial size
50 µg
Concentration
1 mg/mL
Storage
4° C
IL23A protein structure - 16-7129-81 shown in red.