Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations [0]
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- Product number
- 16-7129-85 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- IL-12/IL-23 p40 Monoclonal Antibody (C8.6), Functional Grade, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The C8.6 antibody reacts with the p40 subunit of human IL-12 p70 and human IL-23. IL-12 is a 70 kDa heterodimeric cytokine composed of two covalently linked chains, p40 and p35, and secreted primarily by activated monocytes, macrophages, and dendritic cells. IL-23 is a biologically-related, heterodimeric cytokine composed of disulfide-linked p40 and p19 subunits.
- Antibody clone number
- C8.6
- Concentration
- 1 mg/mL
Submitted references Interleukin-25 initiates Th2 differentiation of human CD4(+) T cells and influences expression of its own receptor.
Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells.
Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists.
Bredo G, Storie J, Shrestha Palikhe N, Davidson C, Adams A, Vliagoftis H, Cameron L
Immunity, inflammation and disease 2015 Dec;3(4):455-68
Immunity, inflammation and disease 2015 Dec;3(4):455-68
Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells.
van de Wetering D, de Paus RA, van Dissel JT, van de Vosse E
PloS one 2009 Dec 21;4(12):e8396
PloS one 2009 Dec 21;4(12):e8396
Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists.
Gorski KS, Waller EL, Bjornton-Severson J, Hanten JA, Riter CL, Kieper WC, Gorden KB, Miller JS, Vasilakos JP, Tomai MA, Alkan SS
International immunology 2006 Jul;18(7):1115-26
International immunology 2006 Jul;18(7):1115-26
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