16250-1-AP
antibody from Proteintech Group
Targeting: CAVIN3
cavin-3, HSRBC, MGC20400, PRKCDBP, SRBC
Antibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 16250-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16250-1-AP, RRID:AB_2171894
- Product name
- PRKCDBP antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PRKCDBP antibody (Cat. #16250-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.
Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response.
Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.
Similar regulatory mechanisms of caveolins and cavins by myocardin family coactivators in arterial and bladder smooth muscle.
Rosiglitazone drives cavin-2/SDPR expression in adipocytes in a CEBPα-dependent manner.
Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1.
Cavin-3 (PRKCDBP) deficiency reduces the density of caveolae in smooth muscle.
Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination.
PTRF/Cavin-1 Deficiency Causes Cardiac Dysfunction Accompanied by Cardiomyocyte Hypertrophy and Cardiac Fibrosis.
P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain.
Myocardin Family Members Drive Formation of Caveolae.
Vasopressin-induced mouse urethral contraction is modulated by caveolin-1.
Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice.
Elevation of PRKCDBP, a novel transcriptional target of TNF-α, and its downregulation by infliximab in patients with ulcerative colitis.
Endocytic crosstalk: cavins, caveolins, and caveolae regulate clathrin-independent endocytosis.
Cavin-3 dictates the balance between ERK and Akt signaling.
Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.
Impaired contractility and detrusor hypertrophy in cavin-1-deficient mice.
Liao Z, Liu H, Ma L, Lei J, Tong B, Li G, Ke W, Wang K, Feng X, Hua W, Li S, Yang C
ACS nano 2021 Sep 28;15(9):14709-14724
ACS nano 2021 Sep 28;15(9):14709-14724
Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response.
McMahon KA, Stroud DA, Gambin Y, Tillu V, Bastiani M, Sierecki E, Polinkovsky ME, Hall TE, Gomez GA, Wu Y, Parat MO, Martel N, Lo HP, Khanna KK, Alexandrov K, Daly R, Yap A, Ryan MT, Parton RG
eLife 2021 Jun 18;10
eLife 2021 Jun 18;10
Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.
McMahon KA, Wu Y, Gambin Y, Sierecki E, Tillu VA, Hall T, Martel N, Okano S, Moradi SV, Ruelcke JE, Ferguson C, Yap AS, Alexandrov K, Hill MM, Parton RG
Nature communications 2019 Jul 22;10(1):3279
Nature communications 2019 Jul 22;10(1):3279
Similar regulatory mechanisms of caveolins and cavins by myocardin family coactivators in arterial and bladder smooth muscle.
Zhu B, Rippe C, Thi Hien T, Zeng J, Albinsson S, Stenkula KG, Uvelius B, Swärd K
PloS one 2017;12(5):e0176759
PloS one 2017;12(5):e0176759
Rosiglitazone drives cavin-2/SDPR expression in adipocytes in a CEBPα-dependent manner.
Hansson B, Rippe C, Kotowska D, Wasserstrom S, Säll J, Göransson O, Swärd K, Stenkula KG
PloS one 2017;12(3):e0173412
PloS one 2017;12(3):e0173412
Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1.
Krawczyk KM, Hansson J, Nilsson H, Krawczyk KK, Swärd K, Johansson ME
BMC nephrology 2017 Oct 24;18(1):320
BMC nephrology 2017 Oct 24;18(1):320
Cavin-3 (PRKCDBP) deficiency reduces the density of caveolae in smooth muscle.
Zhu B, Swärd K, Ekman M, Uvelius B, Rippe C
Cell and tissue research 2017 Jun;368(3):591-602
Cell and tissue research 2017 Jun;368(3):591-602
Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination.
Seemann E, Sun M, Krueger S, Tröger J, Hou W, Haag N, Schüler S, Westermann M, Huebner CA, Romeike B, Kessels MM, Qualmann B
eLife 2017 Dec 5;6
eLife 2017 Dec 5;6
PTRF/Cavin-1 Deficiency Causes Cardiac Dysfunction Accompanied by Cardiomyocyte Hypertrophy and Cardiac Fibrosis.
Taniguchi T, Maruyama N, Ogata T, Kasahara T, Nakanishi N, Miyagawa K, Naito D, Hamaoka T, Nishi M, Matoba S, Ueyama T
PloS one 2016;11(9):e0162513
PloS one 2016;11(9):e0162513
P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain.
Tome ME, Herndon JM, Schaefer CP, Jacobs LM, Zhang Y, Jarvis CK, Davis TP
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016 Nov;36(11):1913-1928
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016 Nov;36(11):1913-1928
Myocardin Family Members Drive Formation of Caveolae.
Krawczyk KK, Yao Mattisson I, Ekman M, Oskolkov N, Grantinge R, Kotowska D, Olde B, Hansson O, Albinsson S, Miano JM, Rippe C, Swärd K
PloS one 2015;10(8):e0133931
PloS one 2015;10(8):e0133931
Vasopressin-induced mouse urethral contraction is modulated by caveolin-1.
Zeng J, Ekman M, Grossi M, Svensson D, Nilsson BO, Jiang C, Uvelius B, Swärd K
European journal of pharmacology 2015 Mar 5;750:59-65
European journal of pharmacology 2015 Mar 5;750:59-65
Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice.
Swärd K, Albinsson S, Rippe C
PloS one 2014;9(3):e92428
PloS one 2014;9(3):e92428
Elevation of PRKCDBP, a novel transcriptional target of TNF-α, and its downregulation by infliximab in patients with ulcerative colitis.
Kim JW, Kim HJ, Lee CK, Shim JJ, Jang JY, Dong SH, Kim BH, Chang YW, Chi SG
Digestive diseases and sciences 2014 Dec;59(12):2947-57
Digestive diseases and sciences 2014 Dec;59(12):2947-57
Endocytic crosstalk: cavins, caveolins, and caveolae regulate clathrin-independent endocytosis.
Chaudhary N, Gomez GA, Howes MT, Lo HP, McMahon KA, Rae JA, Schieber NL, Hill MM, Gaus K, Yap AS, Parton RG
PLoS biology 2014 Apr;12(4):e1001832
PLoS biology 2014 Apr;12(4):e1001832
Cavin-3 dictates the balance between ERK and Akt signaling.
Hernandez VJ, Weng J, Ly P, Pompey S, Dong H, Mishra L, Schwarz M, Anderson RG, Michaely P
eLife 2013 Sep 24;2:e00905
eLife 2013 Sep 24;2:e00905
Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.
Swärd K, Sadegh MK, Mori M, Erjefält JS, Rippe C
Physiological reports 2013 Jun;1(1):e00008
Physiological reports 2013 Jun;1(1):e00008
Impaired contractility and detrusor hypertrophy in cavin-1-deficient mice.
Karbalaei MS, Rippe C, Albinsson S, Ekman M, Mansten A, Uvelius B, Swärd K
European journal of pharmacology 2012 Aug 15;689(1-3):179-85
European journal of pharmacology 2012 Aug 15;689(1-3):179-85
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse lung tissue were subjected to SDS PAGE followed by western blot with 16250-1-AP(PRKCDBP antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using PRKCDBP antibody 16250-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 16250-1-AP(PRKCDBP antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 16250-1-AP(PRKCDBP antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue