DCABH-5728

antibody from Creative Diagnostics

Targeting: KLHL11 FLJ10572

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

DCABH-5728

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-5728, RRID:AB_2479293

Product name

Rabbit Anti-Human FBXW7 monoclonal antibody, clone TQ348

Antibody type

Monoclonal

Description

F-box/WD repeat-containing protein 7 (Fbxw7) is part of an ubiquitin-protein ligase complex. The complex ubiquitinates and degrades several important oncogenes such as mTOR, MYC, AURKA, JUN, and NOTCH1. Fbxw7 cooperates with PTEN for tumor suppression and is widely expressed in many normal tissues. The loss of fbxw7 is associated with malignant progression in a variety of tumors, including carcinoma of colorectum, lung, stomach, bile duct, endometrium, pancreas, breast and glioblastoma.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

TQ348

Storage

2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.