Antibody data
- Antibody Data
- Antigen structure
- References [73]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
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- Product number
- 14528-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14528-1-AP, RRID:AB_2303727
- Product name
- TOM70 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TOM70 antibody (Cat. #14528-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway.
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
Loss-of-function mutation in DDX53 associated with hereditary spastic paraplegia-like disorder.
MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion.
A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass.
Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.
Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies.
Geranylgeranylated-SCF(FBXO10) Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function.
Zika virus modulates mitochondrial dynamics, mitophagy, and mitochondria-derived vesicles to facilitate viral replication in trophoblast cells.
CELLULAR RNA INTERACTS WITH MAVS TO PROMOTE ANTIVIRAL SIGNALING.
The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity.
Sp1 promotes tumour progression by remodelling the mitochondrial network in cervical cancer.
Substitution of PINK1 Gly411 modulates substrate receptivity and turnover.
The Rab5 effector FERRY links early endosomes with mRNA localization.
A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
A proximity labeling strategy enables proteomic analysis of inter-organelle membrane contacts.
SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux.
mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs.
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration.
Novel biallelic mutations in TMEM126B cause splicing defects and lead to Leigh-like syndrome with severe complex I deficiency.
Switching ubiquitous and muscle-specific isoforms of mitochondrial respiratory complex IV in skeletal muscle fine-tunes complex IV activity.
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Impact prediction of translocation of the mitochondrial outer membrane 70 as biomarker in Alzheimer's disease.
Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.
ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response.
UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.
MTCH2 is a mitochondrial outer membrane protein insertase.
Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.
PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c.
Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease.
Temporal Analysis of Protein Ubiquitylation and Phosphorylation During Parkin-Dependent Mitophagy.
Tourniquet-induced lower limb ischemia/reperfusion reduces mitochondrial function by decreasing mitochondrial biogenesis in acute kidney injury in mice.
LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.
TBK1 and GABARAP family members suppress Coxsackievirus B infection by limiting viral production and promoting autophagic degradation of viral extracellular vesicles.
Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.
Differential responses to folic acid in an established keloid fibroblast cell line are mediated by JAK1/2 and STAT3.
Hypothermia promotes mitochondrial elongation In cardiac cells via inhibition of Drp1.
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
Dexamethasone upregulates mitochondrial Tom20, Tom70, and MnSOD through SGK1 in the kidney cells.
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
A membrane arm of mitochondrial complex I sufficient to promote respirasome formation.
Intermittent Use of a Short-Course Glucagon-like Peptide-1 Receptor Agonist Therapy Limits Adverse Cardiac Remodeling via Parkin-dependent Mitochondrial Turnover.
Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay.
A dual druggable genome-wide siRNA and compound library screening approach identifies modulators of parkin recruitment to mitochondria.
Dynamic Regulation of Mitochondrial Import by the Ubiquitin System.
Antiviral Effects of Menthol on Coxsackievirus B.
ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs.
LonP1 regulates mitochondrial network remodeling through the PINK1/Parkin pathway during myoblast differentiation.
EAE-induced upregulation of mitochondrial MnSOD is associated with increases of mitochondrial SGK1 and Tom20 protein in the mouse kidney cortex.
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.
Efficient proximity labeling in living cells and organisms with TurboID.
Yap regulates mitochondrial structural remodeling during myoblast differentiation.
Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis.
GRSF1 suppresses cell senescence.
Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass.
Coxsackievirus B Escapes the Infected Cell in Ejected Mitophagosomes.
Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts.
Presequence-Independent Mitochondrial Import of DNA Ligase Facilitates Establishment of Cell Lines with Reduced mtDNA Copy Number.
Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein.
COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.
Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability.
Directed evolution of APEX2 for electron microscopy and proximity labeling.
Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently.
The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway.
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Bi PY, Killackey SA, Schweizer L, Arnoult D, Philpott DJ, Girardin SE
Communications biology 2024 Mar 30;7(1):391
Communications biology 2024 Mar 30;7(1):391
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS
Molecular cell 2024 Mar 21;84(6):1101-1119.e9
Molecular cell 2024 Mar 21;84(6):1101-1119.e9
Loss-of-function mutation in DDX53 associated with hereditary spastic paraplegia-like disorder.
Yuan X, Wang Y, Li X, Zhong S, Zhou D, Lin X, Fang H, Yang Y, Wang M
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):913-926
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):913-926
MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion.
Goldman A, Mullokandov M, Zaltsman Y, Regev L, Levin-Zaidman S, Gross A
EMBO reports 2024 Jan;25(1):45-67
EMBO reports 2024 Jan;25(1):45-67
A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass.
Sun Y, Cao Y, Wan H, Memetimin A, Cao Y, Li L, Wu C, Wang M, Chen S, Li Q, Ma Y, Dong M, Jiang H
Molecular cell 2024 Jan 18;84(2):327-344.e9
Molecular cell 2024 Jan 18;84(2):327-344.e9
Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.
Li LG, Hu J, Han N, Chen NN, Yu TT, Ren T, Xu HZ, Peng XC, Li XY, Ma TQ, Chen H, Zhang L, Chen X, Wang MF, Li TF
Phytotherapy research : PTR 2024 Aug;38(8):3856-3876
Phytotherapy research : PTR 2024 Aug;38(8):3856-3876
Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies.
Zhu Y, Akkaya KC, Ruta J, Yokoyama N, Wang C, Ruwolt M, Lima DB, Lehmann M, Liu F
Nature communications 2024 Apr 17;15(1):3290
Nature communications 2024 Apr 17;15(1):3290
Geranylgeranylated-SCF(FBXO10) Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function.
Bhat SA, Vasi Z, Jiang L, Selvaraj S, Ferguson R, Gudur A, Ismail H, Adhikari R, Dhabaria A, Ueberheide B, Kuchay S
bioRxiv : the preprint server for biology 2024 Apr 16;
bioRxiv : the preprint server for biology 2024 Apr 16;
Zika virus modulates mitochondrial dynamics, mitophagy, and mitochondria-derived vesicles to facilitate viral replication in trophoblast cells.
Lee JK, Shin OS
Frontiers in immunology 2023;14:1203645
Frontiers in immunology 2023;14:1203645
CELLULAR RNA INTERACTS WITH MAVS TO PROMOTE ANTIVIRAL SIGNALING.
Gokhale NS, Somfleth K, Thompson MG, Sam RK, Marciniak DM, Chu LH, Park M, Dvorkin S, Oberst A, Horner SM, Ong SE, Gale M Jr, Savan R
bioRxiv : the preprint server for biology 2023 Sep 25;
bioRxiv : the preprint server for biology 2023 Sep 25;
The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity.
Stewart H, Lu Y, O'Keefe S, Valpadashi A, Cruz-Zaragoza LD, Michel HA, Nguyen SK, Carnell GW, Lukhovitskaya N, Milligan R, Adewusi Y, Jungreis I, Lulla V, Matthews DA, High S, Rehling P, Emmott E, Heeney JL, Davidson AD, Edgar JR, Smith GL, Firth AE
iScience 2023 Nov 17;26(11):108080
iScience 2023 Nov 17;26(11):108080
Sp1 promotes tumour progression by remodelling the mitochondrial network in cervical cancer.
Xu X, Wang X, Chen Q, Zheng A, Li D, Meng Z, Li X, Cai H, Li W, Huang S, Wang F
Journal of translational medicine 2023 May 6;21(1):307
Journal of translational medicine 2023 May 6;21(1):307
Substitution of PINK1 Gly411 modulates substrate receptivity and turnover.
Fiesel FC, Fričová D, Hayes CS, Coban MA, Hudec R, Bredenberg JM, Broadway BJ, Markham BN, Yan T, Boneski PK, Fiorino G, Watzlawik JO, Hou X, McCarty AM, Lewis-Tuffin LJ, Zhong J, Madden BJ, Ordureau A, An H, Puschmann A, Wszolek ZK, Ross OA, Harper JW, Caulfield TR, Springer W
Autophagy 2023 Jun;19(6):1711-1732
Autophagy 2023 Jun;19(6):1711-1732
The Rab5 effector FERRY links early endosomes with mRNA localization.
Schuhmacher JS, Tom Dieck S, Christoforidis S, Landerer C, Davila Gallesio J, Hersemann L, Seifert S, Schäfer R, Giner A, Toth-Petroczy A, Kalaidzidis Y, Bohnsack KE, Bohnsack MT, Schuman EM, Zerial M
Molecular cell 2023 Jun 1;83(11):1839-1855.e13
Molecular cell 2023 Jun 1;83(11):1839-1855.e13
A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.
Cao Y, Zheng J, Wan H, Sun Y, Fu S, Liu S, He B, Cai G, Cao Y, Huang H, Li Q, Ma Y, Chen S, Wang F, Jiang H
The EMBO journal 2023 Jul 3;42(13):e113033
The EMBO journal 2023 Jul 3;42(13):e113033
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
Li Y, Zhao R, Xiu Z, Yang X, Zhu Y, Han J, Li S, Li Y, Sun L, Li X, Jin N, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
A proximity labeling strategy enables proteomic analysis of inter-organelle membrane contacts.
Zhou M, Kong B, Zhang X, Xiao K, Lu J, Li W, Li M, Li Z, Ji W, Hou J, Xu T
iScience 2023 Jul 21;26(7):107159
iScience 2023 Jul 21;26(7):107159
SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux.
Mozzi A, Oldani M, Forcella ME, Vantaggiato C, Cappelletti G, Pontremoli C, Valenti F, Forni D, Saresella M, Biasin M, Sironi M, Fusi P, Cagliani R
iScience 2023 Jul 21;26(7):107118
iScience 2023 Jul 21;26(7):107118
mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs.
Chen Z, He Q, Lu T, Wu J, Shi G, He L, Zong H, Liu B, Zhu P
Nature communications 2023 Feb 27;14(1):1121
Nature communications 2023 Feb 27;14(1):1121
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration.
Wang Z, Wei D, Bin E, Li J, Jiang K, Lv T, Mao X, Wang F, Dai H, Tang N
Cell stem cell 2023 Aug 3;30(8):1028-1042.e7
Cell stem cell 2023 Aug 3;30(8):1028-1042.e7
Novel biallelic mutations in TMEM126B cause splicing defects and lead to Leigh-like syndrome with severe complex I deficiency.
Zhou X, Lou X, Zhou Y, Xie Y, Han X, Dong Q, Ying X, Laurentinah MR, Zhang L, Chen Z, Li D, Fang H, Lyu J, Yang Y, Wang Y
Journal of human genetics 2023 Apr;68(4):239-246
Journal of human genetics 2023 Apr;68(4):239-246
Switching ubiquitous and muscle-specific isoforms of mitochondrial respiratory complex IV in skeletal muscle fine-tunes complex IV activity.
Ye X, Xie Y, Shi Y, Wang B, Han X, Zhou X, Pan K, Wang M, Fang H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Apr;37(4):e22891
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Apr;37(4):e22891
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
Qiu S, Zhong X, Meng X, Li S, Qian X, Lu H, Cai J, Zhang Y, Wang M, Ye Z, Zhang H, Gao P
Cell research 2023 Apr;33(4):299-311
Cell research 2023 Apr;33(4):299-311
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Koma R, Shibaguchi T, Araiso Y, Yamada T, Nonaka Y, Jue T, Masuda K
Physiological reports 2023 Apr;11(7):e15632
Physiological reports 2023 Apr;11(7):e15632
Impact prediction of translocation of the mitochondrial outer membrane 70 as biomarker in Alzheimer's disease.
Cao X, Chen Y, Sang X, Xu S, Xie Z, Zhu Z, Wang P, Bi J, Xu L
Frontiers in aging neuroscience 2022;14:1013943
Frontiers in aging neuroscience 2022;14:1013943
Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.
Liang S, Zhu C, Suo C, Wei H, Yu Y, Gu X, Chen L, Yuan M, Shen S, Li S, Sun L, Gao P
Frontiers in oncology 2022;12:857968
Frontiers in oncology 2022;12:857968
ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response.
Yildirim AD, Citir M, Dogan AE, Veli Z, Yildirim Z, Tufanli O, Traynor-Kaplan A, Schultz C, Erbay E
Journal of lipid research 2022 Oct;63(10):100279
Journal of lipid research 2022 Oct;63(10):100279
UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.
Zheng J, Cao Y, Yang J, Jiang H
EMBO reports 2022 Oct 6;23(10):e54859
EMBO reports 2022 Oct 6;23(10):e54859
MTCH2 is a mitochondrial outer membrane protein insertase.
Guna A, Stevens TA, Inglis AJ, Replogle JM, Esantsi TK, Muthukumar G, Shaffer KCL, Wang ML, Pogson AN, Jones JJ, Lomenick B, Chou TF, Weissman JS, Voorhees RM
Science (New York, N.Y.) 2022 Oct 21;378(6617):317-322
Science (New York, N.Y.) 2022 Oct 21;378(6617):317-322
Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.
Goldsmith J, Ordureau A, Harper JW, Holzbaur ELF
Neuron 2022 Mar 16;110(6):967-976.e8
Neuron 2022 Mar 16;110(6):967-976.e8
PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c.
Dogan AE, Hamid SM, Yildirim AD, Yildirim Z, Sen G, Riera CE, Gottlieb RA, Erbay E
The Journal of biological chemistry 2022 Jul;298(7):102050
The Journal of biological chemistry 2022 Jul;298(7):102050
Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease.
Barbier-Torres L, Murray B, Yang JW, Wang J, Matsuda M, Robinson A, Binek A, Fan W, Fernández-Ramos D, Lopitz-Otsoa F, Luque-Urbano M, Millet O, Mavila N, Peng H, Ramani K, Gottlieb R, Sun Z, Liangpunsakul S, Seki E, Van Eyk JE, Mato JM, Lu SC
Nature communications 2022 Jan 28;13(1):557
Nature communications 2022 Jan 28;13(1):557
Temporal Analysis of Protein Ubiquitylation and Phosphorylation During Parkin-Dependent Mitophagy.
Zittlau KI, Lechado-Terradas A, Nalpas N, Geisler S, Kahle PJ, Macek B
Molecular & cellular proteomics : MCP 2022 Feb;21(2):100191
Molecular & cellular proteomics : MCP 2022 Feb;21(2):100191
Tourniquet-induced lower limb ischemia/reperfusion reduces mitochondrial function by decreasing mitochondrial biogenesis in acute kidney injury in mice.
Packialakshmi B, Stewart IJ, Burmeister DM, Feng Y, McDaniel DP, Chung KK, Zhou X
Physiological reports 2022 Feb;10(3):e15181
Physiological reports 2022 Feb;10(3):e15181
LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.
Wu Z, Berlemann LA, Bader V, Sehr DA, Dawin E, Covallero A, Meschede J, Angersbach L, Showkat C, Michaelis JB, Münch C, Rieger B, Namgaladze D, Herrera MG, Fiesel FC, Springer W, Mendes M, Stepien J, Barkovits K, Marcus K, Sickmann A, Dittmar G, Busch KB, Riedel D, Brini M, Tatzelt J, Cali T, Winklhofer KF
The EMBO journal 2022 Dec 15;41(24):e112006
The EMBO journal 2022 Dec 15;41(24):e112006
TBK1 and GABARAP family members suppress Coxsackievirus B infection by limiting viral production and promoting autophagic degradation of viral extracellular vesicles.
Sawaged S, Mota T, Piplani H, Thakur R, Lall D, McCabe E, Seo S, Sutterwala FS, Feuer R, Gottlieb RA, Sin J
PLoS pathogens 2022 Aug;18(8):e1010350
PLoS pathogens 2022 Aug;18(8):e1010350
Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.
Wyant GA, Yu W, Doulamis IP, Nomoto RS, Saeed MY, Duignan T, McCully JD, Kaelin WG Jr
Science (New York, N.Y.) 2022 Aug 5;377(6606):621-629
Science (New York, N.Y.) 2022 Aug 5;377(6606):621-629
Differential responses to folic acid in an established keloid fibroblast cell line are mediated by JAK1/2 and STAT3.
McCann KJ, Yadav M, Alishahedani ME, Freeman AF, Myles IA
PloS one 2021;16(3):e0248011
PloS one 2021;16(3):e0248011
Hypothermia promotes mitochondrial elongation In cardiac cells via inhibition of Drp1.
Taylor D, Germano J, Song Y, Hadj-Moussa H, Marek-Iannucci S, Dhanji R, Sin J, Czer LSC, Storey KB, Gottlieb RA
Cryobiology 2021 Oct;102:42-55
Cryobiology 2021 Oct;102:42-55
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, Horlbeck MA, Salemi MR, Phinney BS, Weissman JS, Nunnari J
eLife 2021 May 26;10
eLife 2021 May 26;10
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
Tai Y, Pu M, Yuan L, Guo H, Qiao J, Lu H, Wang G, Chen J, Qi X, Tao Z, Ren J
Life sciences 2021 Jul 1;276:119415
Life sciences 2021 Jul 1;276:119415
Dexamethasone upregulates mitochondrial Tom20, Tom70, and MnSOD through SGK1 in the kidney cells.
Hira S, Packialakshmi B, Tang E, Zhou X
Journal of physiology and biochemistry 2021 Feb;77(1):1-11
Journal of physiology and biochemistry 2021 Feb;77(1):1-11
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.
König T, Nolte H, Aaltonen MJ, Tatsuta T, Krols M, Stroh T, Langer T, McBride HM
Nature cell biology 2021 Dec;23(12):1271-1286
Nature cell biology 2021 Dec;23(12):1271-1286
The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease.
Khodayari N, Wang RL, Oshins R, Lu Y, Millett M, Aranyos AM, Mostofizadeh S, Scindia Y, Flagg TO, Brantly M
International journal of molecular sciences 2021 Dec 9;22(24)
International journal of molecular sciences 2021 Dec 9;22(24)
A membrane arm of mitochondrial complex I sufficient to promote respirasome formation.
Fang H, Ye X, Xie J, Li Y, Li H, Bao X, Yang Y, Lin Z, Jia M, Han Q, Zhu J, Li X, Zhao Q, Yang Y, Lyu J
Cell reports 2021 Apr 13;35(2):108963
Cell reports 2021 Apr 13;35(2):108963
Intermittent Use of a Short-Course Glucagon-like Peptide-1 Receptor Agonist Therapy Limits Adverse Cardiac Remodeling via Parkin-dependent Mitochondrial Turnover.
Germano JF, Huang C, Sin J, Song Y, Tucker KC, Taylor DJR, Saadaeijahromi H, Stotland A, Piplani H, Gottlieb RA, Mentzer RM Jr, Andres AM
Scientific reports 2020 May 19;10(1):8284
Scientific reports 2020 May 19;10(1):8284
Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay.
Wei X, Du M, Xie J, Luo T, Zhou Y, Zhang K, Li J, Chen D, Xu P, Jia M, Zhou H, Fang H, Lyu J, Yang Y
Journal of human genetics 2020 Mar;65(3):231-240
Journal of human genetics 2020 Mar;65(3):231-240
A dual druggable genome-wide siRNA and compound library screening approach identifies modulators of parkin recruitment to mitochondria.
Scott HL, Buckner N, Fernandez-Albert F, Pedone E, Postiglione L, Shi G, Allen N, Wong LF, Magini L, Marucci L, O'Sullivan GA, Cole S, Powell J, Maycox P, Uney JB
The Journal of biological chemistry 2020 Mar 6;295(10):3285-3300
The Journal of biological chemistry 2020 Mar 6;295(10):3285-3300
Dynamic Regulation of Mitochondrial Import by the Ubiquitin System.
Phu L, Rose CM, Tea JS, Wall CE, Verschueren E, Cheung TK, Kirkpatrick DS, Bingol B
Molecular cell 2020 Mar 5;77(5):1107-1123.e10
Molecular cell 2020 Mar 5;77(5):1107-1123.e10
Antiviral Effects of Menthol on Coxsackievirus B.
Taylor DJR, Hamid SM, Andres AM, Saadaeijahromi H, Piplani H, Germano JF, Song Y, Sawaged S, Feuer R, Pandol SJ, Sin J
Viruses 2020 Mar 28;12(4)
Viruses 2020 Mar 28;12(4)
ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs.
Tsai YL, Coady TH, Lu L, Zheng D, Alland I, Tian B, Shneider NA, Manley JL
Genes & development 2020 Jun 1;34(11-12):785-805
Genes & development 2020 Jun 1;34(11-12):785-805
LonP1 regulates mitochondrial network remodeling through the PINK1/Parkin pathway during myoblast differentiation.
Huang S, Wang X, Yu J, Tian Y, Yang C, Chen Y, Chen H, Ge H
American journal of physiology. Cell physiology 2020 Dec 1;319(6):C1020-C1028
American journal of physiology. Cell physiology 2020 Dec 1;319(6):C1020-C1028
EAE-induced upregulation of mitochondrial MnSOD is associated with increases of mitochondrial SGK1 and Tom20 protein in the mouse kidney cortex.
Hira S, Packialakshmi B, Zhou X
The journal of physiological sciences : JPS 2019 Sep;69(5):723-732
The journal of physiological sciences : JPS 2019 Sep;69(5):723-732
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.
Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB
Nature 2019 Nov;575(7782):380-384
Nature 2019 Nov;575(7782):380-384
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z
Nature 2019 Nov;575(7782):375-379
Nature 2019 Nov;575(7782):375-379
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.
Wang J, Wang K, Huang C, Lin D, Zhou Y, Wu Y, Tian N, Fan P, Pan X, Xu D, Hu J, Zhou Y, Wang X, Zhang X
International journal of biological sciences 2018;14(13):1873-1882
International journal of biological sciences 2018;14(13):1873-1882
Efficient proximity labeling in living cells and organisms with TurboID.
Branon TC, Bosch JA, Sanchez AD, Udeshi ND, Svinkina T, Carr SA, Feldman JL, Perrimon N, Ting AY
Nature biotechnology 2018 Oct;36(9):880-887
Nature biotechnology 2018 Oct;36(9):880-887
Yap regulates mitochondrial structural remodeling during myoblast differentiation.
Huang S, Wang X, Wu X, Yu J, Li J, Huang X, Zhu C, Ge H
American journal of physiology. Cell physiology 2018 Oct 1;315(4):C474-C484
American journal of physiology. Cell physiology 2018 Oct 1;315(4):C474-C484
Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis.
Zhou B, Zhang JY, Liu XS, Chen HZ, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q
Cell research 2018 Dec;28(12):1171-1185
Cell research 2018 Dec;28(12):1171-1185
GRSF1 suppresses cell senescence.
Noh JH, Kim KM, Idda ML, Martindale JL, Yang X, Abdelmohsen K, Gorospe M
Aging 2018 Aug 7;10(8):1856-1866
Aging 2018 Aug 7;10(8):1856-1866
Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass.
Andres AM, Tucker KC, Thomas A, Taylor DJ, Sengstock D, Jahania SM, Dabir R, Pourpirali S, Brown JA, Westbrook DG, Ballinger SW, Mentzer RM Jr, Gottlieb RA
JCI insight 2017 Feb 23;2(4):e89303
JCI insight 2017 Feb 23;2(4):e89303
Coxsackievirus B Escapes the Infected Cell in Ejected Mitophagosomes.
Sin J, McIntyre L, Stotland A, Feuer R, Gottlieb RA
Journal of virology 2017 Dec 15;91(24)
Journal of virology 2017 Dec 15;91(24)
Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts.
Sin J, Andres AM, Taylor DJ, Weston T, Hiraumi Y, Stotland A, Kim BJ, Huang C, Doran KS, Gottlieb RA
Autophagy 2016;12(2):369-80
Autophagy 2016;12(2):369-80
Presequence-Independent Mitochondrial Import of DNA Ligase Facilitates Establishment of Cell Lines with Reduced mtDNA Copy Number.
Spadafora D, Kozhukhar N, Alexeyev MF
PloS one 2016;11(3):e0152705
PloS one 2016;11(3):e0152705
Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein.
Xu S, Cherok E, Das S, Li S, Roelofs BA, Ge SX, Polster BM, Boyman L, Lederer WJ, Wang C, Karbowski M
Molecular biology of the cell 2016 Jan 15;27(2):349-59
Molecular biology of the cell 2016 Jan 15;27(2):349-59
COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.
Martinez Lyons A, Ardissone A, Reyes A, Robinson AJ, Moroni I, Ghezzi D, Fernandez-Vizarra E, Zeviani M
Journal of medical genetics 2016 Dec;53(12):846-849
Journal of medical genetics 2016 Dec;53(12):846-849
Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability.
Kang Y, Baker MJ, Liem M, Louber J, McKenzie M, Atukorala I, Ang CS, Keerthikumar S, Mathivanan S, Stojanovski D
eLife 2016 Aug 24;5
eLife 2016 Aug 24;5
Directed evolution of APEX2 for electron microscopy and proximity labeling.
Lam SS, Martell JD, Kamer KJ, Deerinck TJ, Ellisman MH, Mootha VK, Ting AY
Nature methods 2015 Jan;12(1):51-4
Nature methods 2015 Jan;12(1):51-4
Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, Walden H, Muqit MM
EMBO reports 2015 Aug;16(8):939-54
EMBO reports 2015 Aug;16(8):939-54
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.
Bingol B, Tea JS, Phu L, Reichelt M, Bakalarski CE, Song Q, Foreman O, Kirkpatrick DS, Sheng M
Nature 2014 Jun 19;510(7505):370-5
Nature 2014 Jun 19;510(7505):370-5
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently.
Fiesel FC, Moussaud-Lamodière EL, Ando M, Springer W
Journal of cell science 2014 Aug 15;127(Pt 16):3488-504
Journal of cell science 2014 Aug 15;127(Pt 16):3488-504
The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway.
Xu R, Hu Q, Ma Q, Liu C, Wang G
Cell death & disease 2014 Aug 14;5(8):e1373
Cell death & disease 2014 Aug 14;5(8):e1373
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW
Nature 2013 Apr 18;496(7445):372-6
Nature 2013 Apr 18;496(7445):372-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 14528-1-AP(TOM70 antibody) at dilution of 1:1500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using TOMM70A antibody 14528-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-TOM70 (IP:14528-1-AP, 3ug; Detection:14528-1-AP 1:500) with mouse brain tissue lysate 6000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 14528-1-AP(TOM70 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 14528-1-AP(TOM70 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue