Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations [0]
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- Product number
- 613302 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#613302, RRID:AB_315793
- Product name
- Purified anti-H2A.X
- Antibody type
- Polyclonal
- Antigen
- Recominant (partial), N-terminal
- Description
- H2A.X is a 14 kD basal histone and a member of the H2 histone family. This nuclear protein is synthesized in the G1 and S phase of the cell cycle and is known to be important for recombination between immunoglobulin switch regions. H2A.X becomes phosphorylated on serine 139 after double-stranded DNA breaks. Phosphorylated H2A.X promotes DNA repair and maintains genomic stability. The Poly6133 antibody has been shown to be useful for Western blotting and immunofluorescence of human H2A.X.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 200 µl
- Storage
- Upon receipt, store frozen at -20° C.
Submitted references The nucleolus directly regulates p53 export and degradation.
The SET2-RPB1 interaction domain of human RECQ5 is important for transcription-associated genome stability.
Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice.
gamma-H2AX foci as a biomarker for patient X-ray exposure in pediatric cardiac catheterization: are we underestimating radiation risks?
Boyd MT, Vlatkovic N, Rubbi CP
The Journal of cell biology 2011 Sep 5;194(5):689-703
The Journal of cell biology 2011 Sep 5;194(5):689-703
The SET2-RPB1 interaction domain of human RECQ5 is important for transcription-associated genome stability.
Li M, Xu X, Liu Y
Molecular and cellular biology 2011 May;31(10):2090-9
Molecular and cellular biology 2011 May;31(10):2090-9
Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice.
Ramirez-Herrick AM, Mullican SE, Sheehan AM, Conneely OM
Blood 2011 Mar 3;117(9):2681-90
Blood 2011 Mar 3;117(9):2681-90
gamma-H2AX foci as a biomarker for patient X-ray exposure in pediatric cardiac catheterization: are we underestimating radiation risks?
Beels L, Bacher K, De Wolf D, Werbrouck J, Thierens H
Circulation 2009 Nov 10;120(19):1903-9
Circulation 2009 Nov 10;120(19):1903-9
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