THNSL2

This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Description

Threonine synthase like 2

Tissue specificity

Low tissue specificity

Predicted location

Intracellular, Secreted - unknown location

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

2 (88170295 - 88186636)

Ensembl ID

ENSG00000144115  (ver. 103.38)

Orthologs

Mouse Thnsl2: ENSMUSG00000054474

UniProt

Q86YJ6

neXtProt

NX_Q86YJ6

Human splice variants
Mouse splice variants

Protein structure