Antibody data
- Antibody Data
- Antigen structure
- References [420]
- Comments [0]
- Validations
- Western blot [5]
- Immunocytochemistry [4]
- Immunohistochemistry [3]
- Flow cytometry [4]
- Other assay [30]
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Validation data
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- Product number
- MA5-15738 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- GAPDH Loading Control Monoclonal Antibody (GA1R)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Description
- This antibody detects GAPDH from BL-21 bacteria, Sf9 insect, Saccharomyces cerevisiae (yeast), human, mouse, rat, rabbit, hamster, and chicken samples.
- Antibody clone number
- GA1R
- Concentration
- 1 mg/mL
Submitted references Schistosoma mansoni phosphoglycerate mutase: a glycolytic ectoenzyme with thrombolytic potential.
Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats.
Parecoxib inhibits esophageal squamous cell carcinoma progression via the PDK1-AKT pathway.
Dynamic rewiring of biological activity across genotype and lineage revealed by context-dependent functional interactions.
Fucoidan-Mediated Inhibition of Fibrotic Properties in Oral Submucous Fibrosis via the MEG3/miR-181a/Egr1 Axis.
Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.
Structurally Conserved Domains between Flavivirus and Alphavirus Fusion Glycoproteins Contribute to Replication and Infectious-Virion Production.
Trpm8 Expression in Human and Mouse Castration Resistant Prostate Adenocarcinoma Paves the Way for the Preclinical Development of TRPM8-Based Targeted Therapies.
Age-Dependent and Pathway-Specific Bimodal Action of Nicotine on Synaptic Plasticity in the Hippocampus of Mice Lacking the miR-132/212 Genes.
The c-Myc Oncogene Maintains Corneal Epithelial Architecture at Homeostasis, Modulates p63 Expression, and Enhances Proliferation During Tissue Repair.
Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model.
A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress.
NLRP3 Inflammasome Priming and Activation Are Regulated by a Phosphatidylinositol-Dependent Mechanism.
Pressure and curvature control of the cell cycle in epithelia growing under spherical confinement.
ABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context.
Neutrophil stimulation with citrullinated histone H4 slows down calcium influx and reduces NET formation compared with native histone H4.
Pulsed-electromagnetic-field induced osteoblast differentiation requires activation of genes downstream of adenosine receptors A2A and A3.
Development of a porcine model of phenylketonuria with a humanized R408W mutation for gene editing.
Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines.
Regulatory Function of Sympathetic Innervation on the Endo/Lysosomal Trafficking of Acetylcholine Receptor.
Long Noncoding RNA X-Inactive-Specific Transcript Promotes the Secretion of Inflammatory Cytokines in LPS Stimulated Astrocyte Cell Via Sponging miR-29c-3p and Regulating Nuclear Factor of Activated T cell 5 Expression.
Tra2beta-Dependent Regulation of RIO Kinase 3 Splicing During Rift Valley Fever Virus Infection Underscores the Links Between Alternative Splicing and Innate Antiviral Immunity.
Theileria annulata Subtelomere-Encoded Variable Secreted Protein-TA05575 Binds to Bovine RBMX2.
Cyclooxygenase-2 regulates PTHrP transcription in human articular chondrocytes and is involved in the pathophysiology of osteoarthritis in rats.
Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome.
Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition.
Metabolic Adaptation of Macrophages as Mechanism of Defense against Crystalline Silica.
Endoplasmic reticulum tubules limit the size of misfolded protein condensates.
Nuclear SR-protein mediated mRNA quality control is continued in cytoplasmic nonsense-mediated decay.
Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling.
Identification of Translocation Inhibitors Targeting the Type III Secretion System of Enteropathogenic Escherichia coli.
Therapeutic Benefit of Galectin-1: Beyond Membrane Repair, a Multifaceted Approach to LGMD2B.
Prognostic significance of uPA and uPAR expression in patients with cervical cancer undergoing radiotherapy.
Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis.
Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties.
The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding.
Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes.
The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions.
Nicotine abolishes memory-related synaptic strengthening and promotes synaptic depression in the neurogenic dentate gyrus of miR-132/212 knockout mice.
Early heat exposure effect on the heat shock proteins in broilers under acute heat stress.
Sirt1 coordinates with ERα to regulate autophagy and adiposity.
TNF-mediated alveolar macrophage necroptosis drives disease pathogenesis during respiratory syncytial virus infection.
Exosome-transmitted miRNA-335-5p promotes colorectal cancer invasion and metastasis by facilitating EMT via targeting RASA1.
Improved pyrrolysine biosynthesis through phage assisted non-continuous directed evolution of the complete pathway.
Heterologous avian system for quantitative analysis of Syncytin-1 interaction with ASCT2 receptor.
Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss.
Synthetic dysmobility screen unveils an integrated STK40-YAP-MAPK system driving cell migration.
Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage.
β(2)-Adrenergic receptor agonist induced hepatic steatosis in mice: modeling nonalcoholic fatty liver disease in hyperadrenergic states.
The metalloproteinase ADAM10 requires its activity to sustain surface expression.
Changes in microtubule stability in zebrafish (Danio rerio) embryos after glyphosate exposure.
Protein Digests and Pure Peptides from Chia Seed Prevented Adipogenesis and Inflammation by Inhibiting PPARγ and NF-κB Pathways in 3T3L-1 Adipocytes.
Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway.
Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.
Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in Drosophila melanogaster.
ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria.
A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes.
Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology.
Growth factors improve the proliferation of Jeju black pig muscle cells by regulating myogenic differentiation 1 and growth-related genes.
Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G(1)/S cell cycle arrest in human colorectal cancer cells via ROS generation.
The Axonal Glycolytic Pathway Contributes to Sensory Axon Extension and Growth Cone Dynamics.
The WAVE complex associates with sites of saddle membrane curvature.
Effect of Neprilysin Inhibition for Ischemic Mitral Regurgitation after Myocardial Injury.
Dynamin deficiency causes insulin secretion failure and hyperglycemia.
Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development.
Autophagy activation and photoreceptor survival in retinal detachment.
A mouse model of Huntington's disease shows altered ultrastructure of transverse tubules in skeletal muscle fibers.
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy.
Unique Regulation of Intestinal Villus Epithelial Cl(-)/HCO(3)(-) Exchange by Cyclooxygenase Pathway Metabolites of Arachidonic Acid in a Mouse Model of Spontaneous Ileitis.
Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the α-Synuclein Pathology in a Transgenic Mouse Model of Parkinson's Disease.
Antibody-drug nanoparticle induces synergistic treatment efficacies in HER2 positive breast cancer cells.
SOX4 promotes the growth and metastasis of breast cancer.
CircZFR functions as a sponge of miR-578 to promote breast cancer progression by regulating HIF1A expression.
Treatment with galectin-1 improves myogenic potential and membrane repair in dysferlin-deficient models.
Insulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response After Irradiation Injury.
MicroRNA-33b Suppresses Epithelial-Mesenchymal Transition Repressing the MYC-EZH2 Pathway in HER2+ Breast Carcinoma.
NVP-CGM097, an HDM2 Inhibitor, Antagonizes ATP-Binding Cassette Subfamily B Member 1-Mediated Drug Resistance.
RovC - a novel type of hexameric transcriptional activator promoting type VI secretion gene expression.
Discoidin Domain Receptor 1 Regulates Runx2 during Osteogenesis of Osteoblasts and Promotes Bone Ossification via Phosphorylation of p38.
The dynamic interplay between ATP/ADP levels and autophagy sustain neuronal migration in vivo.
Doxorubicin Conjugation to Reovirus Improves Oncolytic Efficacy in Triple-Negative Breast Cancer.
Cell Lineage-Based Stratification for Glioblastoma.
Filgotinib suppresses HIV-1-driven gene transcription by inhibiting HIV-1 splicing and T cell activation.
Structure-based design, synthesis, and evaluation of the biological activity of novel phosphoroorganic small molecule IAP antagonists.
Post-translational modifications of hnRNP A1 differentially modulate retroviral IRES-mediated translation initiation.
Defective Sec61α1 underlies a novel cause of autosomal dominant severe congenital neutropenia.
Rdh54/Tid1 inhibits Rad51-Rad54-mediated D-loop formation and limits D-loop length.
Temporal activation of WNT/β-catenin signaling is sufficient to inhibit SOX10 expression and block melanoma growth.
Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation.
Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway.
High-throughput transcriptomic and proteomic profiling of mesenchymal-amoeboid transition in 3D collagen.
Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons.
Transcriptome analysis of neural progenitor cells derived from Lowe syndrome induced pluripotent stem cells: identification of candidate genes for the neurodevelopmental and eye manifestations.
Increased Level of Long Non-Coding RNA MALAT1 is a Common Feature of Amoeboid Invasion.
Steroid synthesis and metabolism in the equine placenta during placentitis.
Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement.
A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.
Adrenoceptor Expression during Intervertebral Disc Degeneration.
A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons.
DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver.
Oncogenic ALK (F1174L) drives tumorigenesis in cutaneous squamous cell carcinoma.
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.
Rrp6 Moonlights in an RNA Exosome-Independent Manner to Promote Cell Survival and Gene Expression during Stress.
Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development.
The Andes Orthohantavirus NSs Protein Antagonizes the Type I Interferon Response by Inhibiting MAVS Signaling.
The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV.
CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity.
Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes.
A partially disordered region connects gene repression and activation functions of EZH2.
Global targetome analysis reveals critical role of miR-29a in pancreatic stellate cell mediated regulation of PDAC tumor microenvironment.
Alterations of signaling pathways in response to chemical perturbations used to measure mRNA decay rates in yeast.
Cdc48/VCP and Endocytosis Regulate TDP-43 and FUS Toxicity and Turnover.
Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on muscle structure and function.
Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.
Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model.
Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice.
Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability.
Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis.
A1 adenosine receptor signaling reduces Streptococcus pneumoniae adherence to pulmonary epithelial cells by targeting expression of platelet-activating factor receptor.
miR-29a Is Repressed by MYC in Pancreatic Cancer and Its Restoration Drives Tumor-Suppressive Effects via Downregulation of LOXL2.
Schizosaccharomyces pombe DNA translocases Rrp1 and Rrp2 have distinct roles at centromeres and telomeres that ensure genome stability.
Age-dependent changes in electrophysiology and calcium handling: implications for pediatric cardiac research.
Progressive cardiac arrhythmias and ECG abnormalities in the Huntington's disease BACHD mouse model.
Striated Preferentially Expressed Protein Kinase (SPEG)-Deficient Skeletal Muscles Display Fewer Satellite Cells with Reduced Proliferation and Delayed Differentiation.
Promoting roles of long non-coding RNA FAM83H-AS1 in bladder cancer growth, metastasis, and angiogenesis through the c-Myc-mediated ULK3 upregulation.
Bacteria elevate extracellular adenosine to exploit host signaling for blood-brain barrier disruption.
Local Targeting of Lung-Tumor-Associated Macrophages with Pulmonary Delivery of a CSF-1R Inhibitor for the Treatment of Breast Cancer Lung Metastases.
LINC00460-miR-149-5p/miR-150-5p-Mutant p53 Feedback Loop Promotes Oxaliplatin Resistance in Colorectal Cancer.
Mucin-2 knockout is a model of intercellular junction defects, mitochondrial damage and ATP depletion in the intestinal epithelium.
Isolation and Characterization of primary human trabecular meshwork cells from segmental flow regions: New tools for understanding segmental flow.
Involvement of Differentially Expressed microRNAs in the PEGylated Liposome Encapsulated (188)Rhenium-Mediated Suppression of Orthotopic Hypopharyngeal Tumor.
Mechanism and Function of Antiviral RNA Interference in Mice.
Sustained Inflammatory Signalling through Stat1/Stat2/IRF9 Is Associated with Amoeboid Phenotype of Melanoma Cells.
A Novel CD147 Inhibitor, SP-8356, Attenuates Pathological Fibrosis in Alkali-Burned Rat Cornea.
Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration.
VEGF Treatment Ameliorates Depression-Like Behavior in Adult Offspring After Maternal Immune Activation.
Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study.
Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells.
Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.
The Influence of Pro-Inflammatory Factors on Sclerostin and Dickkopf-1 Production in Human Dental Pulp Cells Under Hypoxic Conditions.
miR-98 Modulates Cytokine Production from Human PBMCs in Systemic Lupus Erythematosus by Targeting IL-6 mRNA.
Placental Expression of NEMO Protein in Normal Pregnancy and Preeclampsia.
Enhanced Activity by NKCC1 and Slc26a6 Mediates Acidic pH and Cl(-) Movement after Cardioplegia-Induced Arrest of db/db Diabetic Heart.
Expression of mutant mRNA and protein in pancreatic cells derived from MODY3- iPS cells.
SLMAP3 isoform modulates cardiac gene expression and function.
Mechano-signalling, induced by fullerene C(60) nanofilms, arrests the cell cycle in the G2/M phase and decreases proliferation of liver cancer cells.
Minor ginsenoside F1 improves memory in APP/PS1 mice.
Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.
A ribose-functionalized NAD(+) with unexpected high activity and selectivity for protein poly-ADP-ribosylation.
Chia (Salvia hispanica L.) Seed Total Protein and Protein Fractions Digests Reduce Biomarkers of Inflammation and Atherosclerosis in Macrophages In Vitro.
Angiopoietin-like 4 production upon treatment with hypoxia and L-mimosine in periodontal fibroblasts.
Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.
Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the heterotrimer.
Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies.
N-Dihydrogalactochitosan Potentiates the Radiosensitivity of Liver Metastatic Tumor Cells Originated from Murine Breast Tumors.
Reversible Disruption of Specific Transcription Factor-DNA Interactions Using CRISPR/Cas9.
Inhibition of MYC by the SMARCB1 tumor suppressor.
Role and mechanism of nursing cooperation and tetramethylpyrazine application in post-operative pain in patients undergoing total knee arthroplasty.
An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease.
The miRNA-449 family mediates doxorubicin resistance in triple-negative breast cancer by regulating cell cycle factors.
Role of Norepinephrine in IL-1β-Induced Chondrocyte Dedifferentiation under Physioxia.
Quantitative Proteomics Links the Intermediate Filament Nestin to Resistance to Targeted BRAF Inhibition in Melanoma Cells.
CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release.
Norepinephrine Inhibits Synovial Adipose Stem Cell Chondrogenesis via α2a-Adrenoceptor-Mediated ERK1/2 Activation.
Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder.
Sex differences in nicotine-enhanced Pavlovian conditioned approach in rats.
MicroRNA-421-targeted PDCD4 regulates breast cancer cell proliferation.
Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1.
Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection.
Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism.
Development of Highly Sensitive Biosensors of RAF Dimerization in Cells.
High LET Radiation Overcomes In Vitro Resistance to X-Rays of Chondrosarcoma Cell Lines.
Deacetylation Inhibition Reverses PABPN1-Dependent Muscle Wasting.
A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP.
Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling.
Therapeutic Effects of Nrf2 Activation by Bardoxolone Methyl in Chronic Heart Failure.
Coxiella burnetii Type 4B Secretion System-dependent manipulation of endolysosomal maturation is required for bacterial growth.
Loss of methionine sulfoxide reductases increases resistance to oxidative stress.
PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism.
Peri-adolescent alcohol consumption increases sensitivity and dopaminergic response to nicotine during adulthood in female alcohol-preferring (P) rats: Alterations to α7 nicotinic acetylcholine receptor expression.
Enhanced Killing of Triple-Negative Breast Cancer Cells by Reassortant Reovirus and Topoisomerase Inhibitors.
OBG-like ATPase 1 inhibition attenuates angiotensin II-induced hypertrophic response in human ventricular myocytes via GSK-3beta/beta-catenin signalling.
Development of a Molecularly Stable Gene Therapy Vector for the Treatment of RPGR-Associated X-Linked Retinitis Pigmentosa.
Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK.
Molecular imaging of endothelial activation and mineralization in a mouse model of accelerated atherosclerosis.
Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells.
Zika Virus Production Is Resistant to RNase L Antiviral Activity.
Restoration of primary cilia in obese adipose-derived mesenchymal stem cells by inhibiting Aurora A or extracellular signal-regulated kinase.
Role of forward and reverse signaling in Eph receptor and ephrin mediated cell segregation.
A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation.
Aspirin impairs acetyl-coenzyme A metabolism in redox-compromised yeast cells.
Complement Component 3 Negatively Regulates Antibody Response by Modulation of Red Blood Cell Antigen.
VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters.
Organic Solute Transporter α-β Protects Ileal Enterocytes From Bile Acid-Induced Injury.
PEGylated liposome-encapsulated rhenium-188 radiopharmaceutical inhibits proliferation and epithelial-mesenchymal transition of human head and neck cancer cells in vivo with repeated therapy.
Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases.
Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux.
Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6(S10F) mutant.
Altering lipid droplet homeostasis affects Coxiella burnetii intracellular growth.
Herpes Simplex Virus Type 1 Enhances Expression of the Synaptic Protein Arc for Its Own Benefit.
Melittin induces NSCLC apoptosis via inhibition of miR-183.
The Enzymatic Core of the Parkinson's Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast.
Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα Is Neuroprotective.
miRNA-218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3.
Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection.
Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.
Apoptotic efficacy of multifaceted biosynthesized silver nanoparticles on human adenocarcinoma cells.
Inhibition of Bacterial Gene Transcription with an RpoN-Based Stapled Peptide.
Genetic Reduction or Negative Modulation of mGlu(7) Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome.
Transforming growth factor β1 suppresses proinflammatory gene program independent of its regulation on vascular smooth muscle differentiation and autophagy.
The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy.
RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.
Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation.
Obesity-Activated Adipose-Derived Stromal Cells Promote Breast Cancer Growth and Invasion.
The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity.
HEXIM1-Tat chimera inhibits HIV-1 replication.
Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells.
RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection.
Phage-Antibiotic Synergy via Delayed Lysis.
Antibody-mediated immune suppression by antigen modulation is antigen-specific.
Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor.
ATM‑JAK‑PD‑L1 signaling pathway inhibition decreases EMT and metastasis of androgen‑independent prostate cancer.
Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6.
Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype.
Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease.
Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures.
AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity.
miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells.
Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility.
MiR-744-5p inducing cell death by directly targeting HNRNPC and NFIX in ovarian cancer cells.
SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity.
Overexpression of hexokinase 2 reduces mitochondrial calcium overload in coronary endothelial cells of type 2 diabetic mice.
Voluntary wheel running increases satellite cell abundance and improves recovery from disuse in gastrocnemius muscles from mice.
Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice.
MicroRNA-208a Correlates Apoptosis and Oxidative Stress Induced by H(2)O(2) through Protein Tyrosine Kinase/Phosphatase Balance in Cardiomyocytes.
A brain-enriched Drp1 isoform associates with lysosomes, late endosomes, and the plasma membrane.
Postnatal Development and Distribution of Sympathetic Innervation in Mouse Skeletal Muscle.
Effect and molecular mechanism of mTOR inhibitor rapamycin on temozolomide-induced autophagic death of U251 glioma cells.
EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells.
Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.
Estradiol signaling mediates gender difference in visceral adiposity via autophagy.
Long noncoding RNA MALAT1 suppresses breast cancer metastasis.
Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines.
Functional Assessment of Patient-Derived Retinal Pigment Epithelial Cells Edited by CRISPR/Cas9.
Anti-neuropilin-1 monoclonal antibody suppresses the migration and invasion of human gastric cancer cells via Akt dephosphorylation.
A kindred with mutant IKAROS and autoimmunity.
Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa.
Core circadian clock gene expression in human dental pulp-derived cells in response to L-mimosine, hypoxia and echinomycin.
Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo.
Bromodomain-containing protein 4-independent transcriptional activation by autoimmune regulator (AIRE) and NF-κB.
Sex Specific Alterations in α4*Nicotinic Receptor Expression in the Nucleus Accumbens.
Fusogenic micropeptide Myomixer is essential for satellite cell fusion and muscle regeneration.
Postnatal tendon growth and remodeling require platelet-derived growth factor receptor signaling.
E2F6 Impairs Glycolysis and Activates BDH1 Expression Prior to Dilated Cardiomyopathy.
Diamond, graphite, and graphene oxide nanoparticles decrease migration and invasiveness in glioblastoma cell lines by impairing extracellular adhesion.
Progerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes.
Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles.
Neuroprotective effect of Ruminococcus albus on oxidatively stressed SH-SY5Y cells and animals.
Expression and Subcellular Localization of the Kaposi's Sarcoma-Associated Herpesvirus K15P Protein during Latency and Lytic Reactivation in Primary Effusion Lymphoma Cells.
Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains.
Nimodipine but Not Nifedipine Promotes Expression of Fatty Acid 2-Hydroxylase in a Surgical Stress Model Based on Neuro2a Cells.
Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis.
Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis.
Annexin A6 controls neuronal membrane dynamics throughout chick cranial sensory gangliogenesis.
Elevating expression of MeCP2 T158M rescues DNA binding and Rett syndrome-like phenotypes.
The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts: Implications for the Use of Autologous Blood Products for Muscle Regeneration.
Protective Effect of Met12, a Small Peptide Inhibitor of Fas, on the Retinal Pigment Epithelium and Photoreceptor After Sodium Iodate Injury.
Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain.
HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
RASSF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P(2).
A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity.
Conditioned medium from LS 174T goblet cells treated with oxyresveratrol strengthens tight junctions in Caco-2 cells.
Interactions between the Coxiella burnetii parasitophorous vacuole and the endoplasmic reticulum involve the host protein ORP1L.
Expression of Cav1.3 calcium channel in the human and mouse colon: posttranscriptional inhibition by IFNγ.
Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system.
GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury.
REST regulates the cell cycle for cardiac development and regeneration.
RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.
A module for Rac temporal signal integration revealed with optogenetics.
Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice.
Small-size recombinant adenoviral hexon protein fragments for the production of virus-type specific antibodies.
Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.
The c-Jun N-terminal kinase prevents oxidative stress induced by UV and thermal stresses in corals and human cells.
Control of muscle formation by the fusogenic micropeptide myomixer.
Plasmodium parasite as an effective hepatocellular carcinoma antigen glypican-3 delivery vector.
Mitochondrial connexin40 regulates mitochondrial calcium uptake in coronary endothelial cells.
Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells.
Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment.
FoxO1 interacts with transcription factor EB and differentially regulates mitochondrial uncoupling proteins via autophagy in adipocytes.
Sensitive and Quantitative Three-Color Protein Imaging in Fission Yeast Using Spectrally Diverse, Recoded Fluorescent Proteins with Experimentally-Characterized In Vivo Maturation Kinetics.
Influence of Matrices on 3D-Cultured Prostate Cancer Cells' Drug Response and Expression of Drug-Action Associated Proteins.
Targeted Expression of Catalase to Mitochondria Protects Against Ischemic Myopathy in High-Fat Diet-Fed Mice.
Concomitant beige adipocyte differentiation upon induction of mesenchymal stem cells into brown adipocytes.
Protein-Protein Interactions Suggest Novel Activities of Human Cytomegalovirus Tegument Protein pUL103.
Brief Communication: SIR-2.1-dependent lifespan extension of Caenorhabditis elegans by oxyresveratrol and resveratrol.
Zinc finger protein 407 overexpression upregulates PPAR target gene expression and improves glucose homeostasis in mice.
The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation.
SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.
Exercise training reverses myocardial dysfunction induced by CaMKIIδC overexpression by restoring Ca2+ homeostasis.
Vesicular Galectin-3 levels decrease with donor age and contribute to the reduced osteo-inductive potential of human plasma derived extracellular vesicles.
miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer.
The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.
Registered report: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Progress of endocytic CHRN to autophagic degradation is regulated by RAB5-GTPase and T145 phosphorylation of SH3GLB1 at mouse neuromuscular junctions in vivo.
Stiffness of pancreatic cancer cells is associated with increased invasive potential.
Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling.
FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes.
Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia.
Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma.
Pseudouridine in mRNA: Incorporation, Detection, and Recoding.
The novel function of JADE1S in cytokinesis of epithelial cells.
Tunable and reversible drug control of protein production via a self-excising degron.
Quantitative Proteomic Verification of Membrane Proteins as Potential Therapeutic Targets Located in the 11q13 Amplicon in Cancers.
Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy.
Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.
The amino-terminal tails of histones H2A and H3 coordinate efficient base excision repair, DNA damage signaling and postreplication repair in Saccharomyces cerevisiae.
A small molecule activator of AKT does not reduce ischemic injury of the rat heart.
Histone Sprocket Arginine Residues Are Important for Gene Expression, DNA Repair, and Cell Viability in Saccharomyces cerevisiae.
Legionella suppresses the host unfolded protein response via multiple mechanisms.
Inhibition of notch signalling ameliorates experimental inflammatory arthritis.
Tamoxifen reduces fat mass by boosting reactive oxygen species.
Development of organometallic S6K1 inhibitors.
Biocontainment of genetically modified organisms by synthetic protein design.
Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression.
Experimental colitis is associated with transcriptional inhibition of Na+/Ca2+ exchanger isoform 1 (NCX1) expression by interferon γ in the renal distal convoluted tubules.
ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment.
Genome-wide screening identified that miR-134 acts as a metastasis suppressor by targeting integrin β1 in hepatocellular carcinoma.
Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging.
ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.
miR-638 mediated regulation of BRCA1 affects DNA repair and sensitivity to UV and cisplatin in triple-negative breast cancer.
Expression of matriptase correlates with tumour progression and clinical prognosis in oral squamous cell carcinoma.
miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13.
Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.
Identification of human cytomegalovirus genes important for biogenesis of the cytoplasmic virion assembly complex.
The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes.
Sensitization of mesothelioma cells to platinum-based chemotherapy by GSTπ knockdown.
Growth and differentiation factor 3 induces expression of genes related to differentiation in a model of cancer stem cells and protects them from retinoic acid-induced apoptosis.
Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts.
Role of deregulated microRNAs in breast cancer progression using FFPE tissue.
Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.
Effect of beta-carotene on oxidative stress and expression of cardiac connexin 43.
Local injection of lentivirus encoding LINGO-1-shRNA promotes functional recovery in rats with complete spinal cord transection.
Follicle-stimulating hormone inhibits apoptosis in ovarian cancer cells by regulating the OCT4 stem cell signaling pathway.
A small molecule multi-kinase inhibitor reduces influenza A virus replication by restricting viral RNA synthesis.
Epithelial-mesenchymal transition and tumor suppression are controlled by a reciprocal feedback loop between ZEB1 and Grainyhead-like-2.
Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein.
Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation.
Novel oleanolic vinyl boronates: synthesis and antitumor activity.
Over-expression of the overexpressed in lung cancer 1 is associated with poor prognosis in epithelial ovarian cancer.
c-di-GMP signaling regulates E. coli O157:H7 adhesion to colonic epithelium.
Comparison of first dimension IPG and NEPHGE techniques in two-dimensional gel electrophoresis experiment with cytosolic unfolded protein response in Saccharomyces cerevisiae.
Endothelial glucocorticoid receptor is required for protection against sepsis.
Involvement of endoplasmic reticulum stress in tauopathy.
The promotion of functional recovery and nerve regeneration after spinal cord injury by lentiviral vectors encoding Lingo-1 shRNA delivered by Pluronic F-127.
Glucocorticoid receptor-beta up-regulation and steroid resistance induction by IL-17 and IL-23 cytokine stimulation in peripheral mononuclear cells.
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.
A transient α-helical molecular recognition element in the disordered N-terminus of the Sgs1 helicase is critical for chromosome stability and binding of Top3/Rmi1.
Deubiquitylation and stabilization of PTEN by USP13.
Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+ handling in ageing rabbit hearts.
Oleanolic acid and ursolic acid: novel hepatitis C virus antivirals that inhibit NS5B activity.
Histone deacetylase inhibitors induce epithelial-to-mesenchymal transition in prostate cancer cells.
Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM.
Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease.
Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment.
Comparative effects of liensinine and neferine on the human ether-a-go-go-related gene potassium channel and pharmacological activity analysis.
Glucocorticoids augment survival and proliferation of tumor cells.
Hypothyroidism reduces ObRb-STAT3 leptin signalling in the hypothalamus and pituitary of rats associated with resistance to leptin acute anorectic action.
Menthol inhibits the proliferation and motility of prostate cancer DU145 cells.
LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker.
Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer.
The use of sigmoid pH gradients in free-flow isoelectric focusing of human endothelial cell proteins.
Side-stream smoking reduces intestinal inflammation and increases expression of tight junction proteins.
Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms.
AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity.
In vitro and in vivo evaluations on osteogenesis and biodegradability of a β-tricalcium phosphate coated magnesium alloy.
Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids.
In vivo, cardiac-specific knockdown of a target protein, malic enzyme-1, in rat via adenoviral delivery of DNA for non-native miRNA.
HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.
Functional duality of astrocytes in myelination.
A novel luciferase and GFP dual reporter virus for rapid and convenient evaluation of hepatitis C virus replication.
Presynaptic stimulus-release and postsynaptic compensatory changes in mice lacking the N-type calcium channel α(1B)-subunit.
Role of checkpoint kinase 1 (Chk1) in the mechanisms of resistance to histone deacetylase inhibitors.
Characterization of human chondrocytes exposed to simulated microgravity.
Induction of glucocorticoid receptor-beta expression in epithelial cells of asthmatic airways by T-helper type 17 cytokines.
Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents.
Application of free-flow IEF to identify protein candidates changing under microgravity conditions.
The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell.
Ca(2+)/calmodulin-dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na(+)/H(+) exchanger activation.
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice.
Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells.
Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.
The effects of repeated allergen challenge on airway smooth muscle structural and molecular remodeling in a rat model of allergic asthma.
The JNK pathway amplifies and drives subcellular changes in tau phosphorylation.
A citrus extract containing flavanones represses plasminogen activator inhibitor-1 (PAI-1) expression and regulates multiple inflammatory, tissue repair, and fibrosis genes in human colon fibroblasts.
Effects of TRPM8 on the proliferation and motility of prostate cancer PC-3 cells.
Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1.
Transcriptional activation of insulin-like growth factor binding protein 6 by 17beta-estradiol in SaOS-2 cells.
TAK1 is an essential regulator of BMP signalling in cartilage.
miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells.
Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation.
Vascular endothelial growth factor induces extracellular matrix proteins and osteopontin in the umbilical artery.
Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells.
Effects of basic fibroblast growth factor on endothelial cells under conditions of simulated microgravity.
Combination of peptide OFFGEL fractionation and label-free quantitation facilitated proteomics profiling of extraocular muscle.
Expression of vascular endothelial growth factor and receptor tyrosine kinases in cardiac ischemia/reperfusion injury.
Heart-specific inhibition of protooncogene c-myc attenuates cold-induced cardiac hypertrophy.
Comparison of protective effects of trimetazidine against experimental warm ischemia of different durations: early and long-term effects in a pig kidney model.
Calcineurin in reactive astrocytes plays a key role in the interplay between proinflammatory and anti-inflammatory signals.
Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation.
Reduced inotropic effect of nifekalant in failing hearts in rats.
Induction of heat shock response protects the heart against atrial fibrillation.
Calpain inhibition prevents pacing-induced cellular remodeling in a HL-1 myocyte model for atrial fibrillation.
Increased expression of cardiac angiotensin II type 1 (AT(1)) receptors decreases myocardial microvessel density after experimental myocardial infarction.
LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer.
Activation of proteolysis by calpains and structural changes in human paroxysmal and persistent atrial fibrillation.
Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation: differential regulation of protein and mRNA levels for K+ channels.
Ion channel remodeling is related to intraoperative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation.
Pirovich DB, Da'dara AA, Skelly PJ
Parasite (Paris, France) 2022;29:41
Parasite (Paris, France) 2022;29:41
Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats.
Oka K, Fujioka S, Kawamura Y, Komohara Y, Chujo T, Sekiguchi K, Yamamura Y, Oiwa Y, Omamiuda-Ishikawa N, Komaki S, Sutoh Y, Sakurai S, Tomizawa K, Bono H, Shimizu A, Araki K, Yamamoto T, Yamada Y, Oshiumi H, Miura K
Communications biology 2022 Mar 30;5(1):287
Communications biology 2022 Mar 30;5(1):287
Parecoxib inhibits esophageal squamous cell carcinoma progression via the PDK1-AKT pathway.
Huang HM, Huang XY, Wu SP, Chen CK, He XH, Zhang YF
Cellular & molecular biology letters 2022 Mar 19;27(1):28
Cellular & molecular biology letters 2022 Mar 19;27(1):28
Dynamic rewiring of biological activity across genotype and lineage revealed by context-dependent functional interactions.
Kim E, Novak LC, Lin C, Colic M, Bertolet LL, Gheorghe V, Bristow CA, Hart T
Genome biology 2022 Jun 29;23(1):140
Genome biology 2022 Jun 29;23(1):140
Fucoidan-Mediated Inhibition of Fibrotic Properties in Oral Submucous Fibrosis via the MEG3/miR-181a/Egr1 Axis.
Fang CY, Chen SH, Huang CC, Liao YW, Chao SC, Yu CC
Pharmaceuticals (Basel, Switzerland) 2022 Jul 5;15(7)
Pharmaceuticals (Basel, Switzerland) 2022 Jul 5;15(7)
Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.
Peris L, Parato J, Qu X, Soleilhac JM, Lanté F, Kumar A, Pero ME, Martínez-Hernández J, Corrao C, Falivelli G, Payet F, Gory-Fauré S, Bosc C, Blanca Ramirez M, Sproul A, Brocard J, Di Cara B, Delagrange P, Buisson A, Goldberg Y, Moutin MJ, Bartolini F, Andrieux A
Brain : a journal of neurology 2022 Jul 29;145(7):2486-2506
Brain : a journal of neurology 2022 Jul 29;145(7):2486-2506
Structurally Conserved Domains between Flavivirus and Alphavirus Fusion Glycoproteins Contribute to Replication and Infectious-Virion Production.
Rangel MV, Catanzaro N, Thannickal SA, Crotty KA, Noval MG, Johnson KEE, Ghedin E, Lazear HM, Stapleford KA
Journal of virology 2022 Jan 26;96(2):e0177421
Journal of virology 2022 Jan 26;96(2):e0177421
Trpm8 Expression in Human and Mouse Castration Resistant Prostate Adenocarcinoma Paves the Way for the Preclinical Development of TRPM8-Based Targeted Therapies.
Genovesi S, Moro R, Vignoli B, De Felice D, Canossa M, Montironi R, Carbone FG, Barbareschi M, Lunardi A, Alaimo A
Biomolecules 2022 Jan 23;12(2)
Biomolecules 2022 Jan 23;12(2)
Age-Dependent and Pathway-Specific Bimodal Action of Nicotine on Synaptic Plasticity in the Hippocampus of Mice Lacking the miR-132/212 Genes.
Stojanovic T, Velarde Gamez D, Schuld GJ, Bormann D, Cabatic M, Uhrin P, Lubec G, Monje FJ
Cells 2022 Jan 13;11(2)
Cells 2022 Jan 13;11(2)
The c-Myc Oncogene Maintains Corneal Epithelial Architecture at Homeostasis, Modulates p63 Expression, and Enhances Proliferation During Tissue Repair.
Portal C, Wang Z, Scott DK, Wolosin JM, Iomini C
Investigative ophthalmology & visual science 2022 Feb 1;63(2):3
Investigative ophthalmology & visual science 2022 Feb 1;63(2):3
Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model.
Li Q, Lin J, Widrick JJ, Luo S, Li G, Zhang Y, Laporte J, Perrella MA, Liu X, Agrawal PB
JCI insight 2022 Aug 8;7(15)
JCI insight 2022 Aug 8;7(15)
A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress.
Griffin WC, McKinzey DR, Klinzing KN, Baratam R, Eliyapura A, Trakselis MA
Nature communications 2022 Aug 30;13(1):5090
Nature communications 2022 Aug 30;13(1):5090
NLRP3 Inflammasome Priming and Activation Are Regulated by a Phosphatidylinositol-Dependent Mechanism.
Hamilton C, Olona A, Leishman S, MacDonald-Ramsahai K, Cockcroft S, Larrouy-Maumus G, Anand PK
ImmunoHorizons 2022 Aug 29;6(8):642-659
ImmunoHorizons 2022 Aug 29;6(8):642-659
Pressure and curvature control of the cell cycle in epithelia growing under spherical confinement.
Di Meglio I, Trushko A, Guillamat P, Blanch-Mercader C, Abuhattum S, Roux A
Cell reports 2022 Aug 23;40(8):111227
Cell reports 2022 Aug 23;40(8):111227
ABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context.
Jones HBL, Heilig R, Fischer R, Kessler BM, Pinto-Fernández A
Frontiers in chemistry 2021;9:640105
Frontiers in chemistry 2021;9:640105
Neutrophil stimulation with citrullinated histone H4 slows down calcium influx and reduces NET formation compared with native histone H4.
Shi L, Aymonnier K, Wagner DD
PloS one 2021;16(5):e0251726
PloS one 2021;16(5):e0251726
Pulsed-electromagnetic-field induced osteoblast differentiation requires activation of genes downstream of adenosine receptors A2A and A3.
Kar NS, Ferguson D, Zhang N, Waldorff EI, Ryaby JT, DiDonato JA
PloS one 2021;16(2):e0247659
PloS one 2021;16(2):e0247659
Development of a porcine model of phenylketonuria with a humanized R408W mutation for gene editing.
Kaiser RA, Carlson DF, Allen KL, Webster DA, VanLith CJ, Nicolas CT, Hillin LG, Yu Y, Kaiser CW, Wahoff WR, Hickey RD, Watson AL, Winn SR, Thöny B, Kern DR, Harding CO, Lillegard JB
PloS one 2021;16(1):e0245831
PloS one 2021;16(1):e0245831
Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines.
Acuña-Hinrichsen F, Covarrubias-Pinto A, Ishizuka Y, Stolzenbach MF, Martin C, Salazar P, Castro MA, Bramham CR, Otth C
Frontiers in cellular neuroscience 2021;15:580717
Frontiers in cellular neuroscience 2021;15:580717
Regulatory Function of Sympathetic Innervation on the Endo/Lysosomal Trafficking of Acetylcholine Receptor.
Straka T, Schröder C, Roos A, Kollipara L, Sickmann A, Williams MPI, Hafner M, Khan MM, Rudolf R
Frontiers in physiology 2021;12:626707
Frontiers in physiology 2021;12:626707
Long Noncoding RNA X-Inactive-Specific Transcript Promotes the Secretion of Inflammatory Cytokines in LPS Stimulated Astrocyte Cell Via Sponging miR-29c-3p and Regulating Nuclear Factor of Activated T cell 5 Expression.
Zhang M, Yang H, Chen Z, Hu X, Wu T, Liu W
Frontiers in endocrinology 2021;12:573143
Frontiers in endocrinology 2021;12:573143
Tra2beta-Dependent Regulation of RIO Kinase 3 Splicing During Rift Valley Fever Virus Infection Underscores the Links Between Alternative Splicing and Innate Antiviral Immunity.
White LA, Bisom TC, Grimes HL, Hayashi M, Lanchy JM, Lodmell JS
Frontiers in cellular and infection microbiology 2021;11:799024
Frontiers in cellular and infection microbiology 2021;11:799024
Theileria annulata Subtelomere-Encoded Variable Secreted Protein-TA05575 Binds to Bovine RBMX2.
Li Z, Liu J, Zhao S, Ma Q, Liu A, Li Y, Guan G, Luo J, Yin H
Frontiers in cellular and infection microbiology 2021;11:644983
Frontiers in cellular and infection microbiology 2021;11:644983
Cyclooxygenase-2 regulates PTHrP transcription in human articular chondrocytes and is involved in the pathophysiology of osteoarthritis in rats.
Chang LH, Chen CH, Wu SC, Chang JK, Ho ML
Journal of orthopaedic translation 2021 Sep;30:16-30
Journal of orthopaedic translation 2021 Sep;30:16-30
Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome.
Brault V, Nguyen TL, Flores-Gutiérrez J, Iacono G, Birling MC, Lalanne V, Meziane H, Manousopoulou A, Pavlovic G, Lindner L, Selloum M, Sorg T, Yu E, Garbis SD, Hérault Y
PLoS genetics 2021 Sep;17(9):e1009777
PLoS genetics 2021 Sep;17(9):e1009777
Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition.
Kadgien CA, Kamesh A, Milnerwood AJ
Molecular brain 2021 Sep 16;14(1):143
Molecular brain 2021 Sep 16;14(1):143
Metabolic Adaptation of Macrophages as Mechanism of Defense against Crystalline Silica.
Marrocco A, Frawley K, Pearce LL, Peterson J, O'Brien JP, Mullett SJ, Wendell SG, St Croix CM, Mischler SE, Ortiz LA
Journal of immunology (Baltimore, Md. : 1950) 2021 Sep 15;207(6):1627-1640
Journal of immunology (Baltimore, Md. : 1950) 2021 Sep 15;207(6):1627-1640
Endoplasmic reticulum tubules limit the size of misfolded protein condensates.
Parashar S, Chidambaram R, Chen S, Liem CR, Griffis E, Lambert GG, Shaner NC, Wortham M, Hay JC, Ferro-Novick S
eLife 2021 Sep 1;10
eLife 2021 Sep 1;10
Nuclear SR-protein mediated mRNA quality control is continued in cytoplasmic nonsense-mediated decay.
Grosse S, Lu YY, Coban I, Neumann B, Krebber H
RNA biology 2021 Oct;18(10):1390-1407
RNA biology 2021 Oct;18(10):1390-1407
Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling.
Araya LE, Soni IV, Hardy JA, Julien O
ACS chemical biology 2021 Nov 19;16(11):2280-2296
ACS chemical biology 2021 Nov 19;16(11):2280-2296
Identification of Translocation Inhibitors Targeting the Type III Secretion System of Enteropathogenic Escherichia coli.
Mühlen S, Zapol'skii VA, Bilitewski U, Dersch P
Antimicrobial agents and chemotherapy 2021 Nov 17;65(12):e0095821
Antimicrobial agents and chemotherapy 2021 Nov 17;65(12):e0095821
Therapeutic Benefit of Galectin-1: Beyond Membrane Repair, a Multifaceted Approach to LGMD2B.
Vallecillo-Zúniga ML, Poulson PD, Luddington JS, Arnold CJ, Rathgeber M, Kartchner BC, Hayes S, Gill H, Valdoz JC, Spallino JL, Garfield S, Dodson EL, Arthur CM, Stowell SR, Van Ry PM
Cells 2021 Nov 17;10(11)
Cells 2021 Nov 17;10(11)
Prognostic significance of uPA and uPAR expression in patients with cervical cancer undergoing radiotherapy.
Nantajit D, Chailapakul P, Bawornpatarapakorn S, Chamchod S, Laebua K
Oncology letters 2021 May;21(5):423
Oncology letters 2021 May;21(5):423
Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis.
Zhang S, Yuan B, Lam JH, Zhou J, Zhou X, Ramos-Mandujano G, Tian X, Liu Y, Han R, Li Y, Gao X, Li M, Yang M
Cell discovery 2021 May 4;7(1):30
Cell discovery 2021 May 4;7(1):30
Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties.
Lucà R, Assenza MR, Maiullari F, Pieroni L, Maiullari S, Federici G, Marini F, Rizzi R, Urbani A, Soddu S, Moretti F
Cell death & disease 2021 May 29;12(6):558
Cell death & disease 2021 May 29;12(6):558
The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding.
Kuramoto K, Kim YJ, Hong JH, He C
Cell reports 2021 May 25;35(8):109184
Cell reports 2021 May 25;35(8):109184
Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes.
Filippini A, Mutti V, Faustini G, Longhena F, Ramazzina I, Rizzi F, Kaganovich A, Roosen DA, Landeck N, Duffy M, Tessari I, Bono F, Fiorentini C, Greggio E, Bubacco L, Bellucci A, Missale M, Cookson MR, Gennarelli M, Russo I
Glia 2021 Mar;69(3):681-696
Glia 2021 Mar;69(3):681-696
The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions.
Chakrapani B, Khan MIK, Kadumuri RV, Gupta S, Verma M, Awasthi S, Govindaraju G, Mahesh A, Rajavelu A, Chavali S, Dhayalan A
Life science alliance 2021 Mar;4(3)
Life science alliance 2021 Mar;4(3)
Nicotine abolishes memory-related synaptic strengthening and promotes synaptic depression in the neurogenic dentate gyrus of miR-132/212 knockout mice.
Stojanovic T, Benes H, Awad A, Bormann D, Monje FJ
Addiction biology 2021 Mar;26(2):e12905
Addiction biology 2021 Mar;26(2):e12905
Early heat exposure effect on the heat shock proteins in broilers under acute heat stress.
Kang D, Shim K
Poultry science 2021 Mar;100(3):100964
Poultry science 2021 Mar;100(3):100964
Sirt1 coordinates with ERα to regulate autophagy and adiposity.
Tao Z, Shi L, Parke J, Zheng L, Gu W, Dong XC, Liu D, Wang Z, Olumi AF, Cheng Z
Cell death discovery 2021 Mar 15;7(1):53
Cell death discovery 2021 Mar 15;7(1):53
TNF-mediated alveolar macrophage necroptosis drives disease pathogenesis during respiratory syncytial virus infection.
Santos LD, Antunes KH, Muraro SP, de Souza GF, da Silva AG, Felipe JS, Zanetti LC, Czepielewski RS, Magnus K, Scotta M, Mattiello R, Maito F, de Souza APD, Weinlich R, Vinolo MAR, Porto BN
The European respiratory journal 2021 Jun;57(6)
The European respiratory journal 2021 Jun;57(6)
Exosome-transmitted miRNA-335-5p promotes colorectal cancer invasion and metastasis by facilitating EMT via targeting RASA1.
Sun X, Lin F, Sun W, Zhu W, Fang D, Luo L, Li S, Zhang W, Jiang L
Molecular therapy. Nucleic acids 2021 Jun 4;24:164-174
Molecular therapy. Nucleic acids 2021 Jun 4;24:164-174
Improved pyrrolysine biosynthesis through phage assisted non-continuous directed evolution of the complete pathway.
Ho JML, Miller CA, Smith KA, Mattia JR, Bennett MR
Nature communications 2021 Jun 24;12(1):3914
Nature communications 2021 Jun 24;12(1):3914
Heterologous avian system for quantitative analysis of Syncytin-1 interaction with ASCT2 receptor.
Štafl K, Trávníček M, Kučerová D, Pecnová Ľ, Krchlíková V, Gáliková E, Stepanets V, Hejnar J, Trejbalová K
Retrovirology 2021 Jun 22;18(1):15
Retrovirology 2021 Jun 22;18(1):15
Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss.
Amegandjin CA, Choudhury M, Jadhav V, Carriço JN, Quintal A, Berryer M, Snapyan M, Chattopadhyaya B, Saghatelyan A, Di Cristo G
Nature communications 2021 Jun 16;12(1):3653
Nature communications 2021 Jun 16;12(1):3653
Synthetic dysmobility screen unveils an integrated STK40-YAP-MAPK system driving cell migration.
Yu LY, Tseng TJ, Lin HC, Hsu CL, Lu TX, Tsai CJ, Lin YC, Chu I, Peng CT, Chen HJ, Tsai FC
Science advances 2021 Jul;7(31)
Science advances 2021 Jul;7(31)
Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage.
Wu X, Wang B
Nature communications 2021 Jul 16;12(1):4373
Nature communications 2021 Jul 16;12(1):4373
β(2)-Adrenergic receptor agonist induced hepatic steatosis in mice: modeling nonalcoholic fatty liver disease in hyperadrenergic states.
Shi Y, Pizzini J, Wang H, Das F, Abdul Azees PA, Ghosh Choudhury G, Barnes JL, Zang M, Weintraub ST, Yeh CK, Katz MS, Kamat A
American journal of physiology. Endocrinology and metabolism 2021 Jul 1;321(1):E90-E104
American journal of physiology. Endocrinology and metabolism 2021 Jul 1;321(1):E90-E104
The metalloproteinase ADAM10 requires its activity to sustain surface expression.
Seifert A, Düsterhöft S, Wozniak J, Koo CZ, Tomlinson MG, Nuti E, Rossello A, Cuffaro D, Yildiz D, Ludwig A
Cellular and molecular life sciences : CMLS 2021 Jan;78(2):715-732
Cellular and molecular life sciences : CMLS 2021 Jan;78(2):715-732
Changes in microtubule stability in zebrafish (Danio rerio) embryos after glyphosate exposure.
Díaz-Martín RD, Valencia-Hernández JD, Betancourt-Lozano M, Yáñez-Rivera B
Heliyon 2021 Jan;7(1):e06027
Heliyon 2021 Jan;7(1):e06027
Protein Digests and Pure Peptides from Chia Seed Prevented Adipogenesis and Inflammation by Inhibiting PPARγ and NF-κB Pathways in 3T3L-1 Adipocytes.
Grancieri M, Martino HSD, Gonzalez de Mejia E
Nutrients 2021 Jan 8;13(1)
Nutrients 2021 Jan 8;13(1)
Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway.
Findakly S, Daggubati V, Garcia G, LaStella SA, Choudhury A, Tran C, Li A, Tong P, Garcia JQ, Puri N, Reiter JF, Xu L, Raleigh DR
The Journal of cell biology 2021 Jan 4;220(1)
The Journal of cell biology 2021 Jan 4;220(1)
Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.
Zhang Y, Seemann J
The Journal of cell biology 2021 Jan 4;220(1)
The Journal of cell biology 2021 Jan 4;220(1)
Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in Drosophila melanogaster.
Cho DG, Lee SS, Cho KO
Molecules and cells 2021 Jan 31;44(1):13-25
Molecules and cells 2021 Jan 31;44(1):13-25
ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria.
Kester JC, Kandror O, Akopian T, Chase MR, Zhu J, Rubin EJ, Goldberg AL, Fortune SM
Journal of bacteriology 2021 Jan 25;203(4)
Journal of bacteriology 2021 Jan 25;203(4)
A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes.
Fisher NM, AlHashim A, Buch AB, Badivuku H, Samman MM, Weiss KM, Cestero GI, Does MD, Rook JM, Lindsley CW, Conn PJ, Gogliotti RG, Niswender CM
JCI insight 2021 Feb 22;6(4)
JCI insight 2021 Feb 22;6(4)
Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology.
Errington TM, Denis A, Allison AB, Araiza R, Aza-Blanc P, Bower LR, Campos J, Chu H, Denson S, Donham C, Harr K, Haven B, Iorns E, Kwok J, McDonald E, Pelech S, Perfito N, Pike A, Sampey D, Settles M, Scott DA, Sharma V, Tolentino T, Trinh A, Tsui R, Willis B, Wood J, Young L
eLife 2021 Dec 7;10
eLife 2021 Dec 7;10
Growth factors improve the proliferation of Jeju black pig muscle cells by regulating myogenic differentiation 1 and growth-related genes.
Park J, Lee J, Song KD, Kim SJ, Kim DC, Lee SC, Son YJ, Choi HW, Shim K
Animal bioscience 2021 Aug;34(8):1392-1402
Animal bioscience 2021 Aug;34(8):1392-1402
Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G(1)/S cell cycle arrest in human colorectal cancer cells via ROS generation.
Zhang SP, Zhou J, Fan QZ, Lv XM, Wang T, Wang F, Chen Y, Hong SY, Liu XP, Xu BS, Hu L, Zhang C, Zhang YM
Experimental and therapeutic medicine 2021 Aug;22(2):829
Experimental and therapeutic medicine 2021 Aug;22(2):829
The Axonal Glycolytic Pathway Contributes to Sensory Axon Extension and Growth Cone Dynamics.
Ketschek A, Sainath R, Holland S, Gallo G
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Aug 4;41(31):6637-6651
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Aug 4;41(31):6637-6651
The WAVE complex associates with sites of saddle membrane curvature.
Pipathsouk A, Brunetti RM, Town JP, Graziano BR, Breuer A, Pellett PA, Marchuk K, Tran NT, Krummel MF, Stamou D, Weiner OD
The Journal of cell biology 2021 Aug 2;220(8)
The Journal of cell biology 2021 Aug 2;220(8)
Effect of Neprilysin Inhibition for Ischemic Mitral Regurgitation after Myocardial Injury.
Lee S, Hwang HS, Song N, Kang GH, Choi KH, Ji E, Song JM, Kang DH
International journal of molecular sciences 2021 Aug 10;22(16)
International journal of molecular sciences 2021 Aug 10;22(16)
Dynamin deficiency causes insulin secretion failure and hyperglycemia.
Fan F, Wu Y, Hara M, Rizk A, Ji C, Nerad D, Tamarina N, Lou X
Proceedings of the National Academy of Sciences of the United States of America 2021 Aug 10;118(32)
Proceedings of the National Academy of Sciences of the United States of America 2021 Aug 10;118(32)
Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development.
Lewandowski CT, Khan MW, BenAissa M, Dubrovskyi O, Ackerman-Berrier M, LaDu MJ, Layden BT, Thatcher GRJ
EBioMedicine 2021 Apr;66:103287
EBioMedicine 2021 Apr;66:103287
Autophagy activation and photoreceptor survival in retinal detachment.
Xiao J, Yao J, Jia L, Ferguson TA, Weber S, Sundstrom JM, Wubben TJ, Besirli CG, Zacks DN
Experimental eye research 2021 Apr;205:108492
Experimental eye research 2021 Apr;205:108492
A mouse model of Huntington's disease shows altered ultrastructure of transverse tubules in skeletal muscle fibers.
Romer SH, Metzger S, Peraza K, Wright MC, Jobe DS, Song LS, Rich MM, Foy BD, Talmadge RJ, Voss AA
The Journal of general physiology 2021 Apr 5;153(4)
The Journal of general physiology 2021 Apr 5;153(4)
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy.
Verweij MC, Hansen SG, Iyer R, John N, Malouli D, Morrow D, Scholz I, Womack J, Abdulhaqq S, Gilbride RM, Hughes CM, Ventura AB, Ford JC, Selseth AN, Oswald K, Shoemaker R, Berkemeier B, Bosche WJ, Hull M, Shao J, Sacha JB, Axthelm MK, Edlefsen PT, Lifson JD, Picker LJ, Früh K
Science (New York, N.Y.) 2021 Apr 30;372(6541)
Science (New York, N.Y.) 2021 Apr 30;372(6541)
Unique Regulation of Intestinal Villus Epithelial Cl(-)/HCO(3)(-) Exchange by Cyclooxygenase Pathway Metabolites of Arachidonic Acid in a Mouse Model of Spontaneous Ileitis.
Rahman MM, Borthakur A, Afroz S, Arthur S, Sundaram U
International journal of molecular sciences 2021 Apr 17;22(8)
International journal of molecular sciences 2021 Apr 17;22(8)
Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the α-Synuclein Pathology in a Transgenic Mouse Model of Parkinson's Disease.
Portz P, Lee MK
Cells 2021 Apr 13;10(4)
Cells 2021 Apr 13;10(4)
Antibody-drug nanoparticle induces synergistic treatment efficacies in HER2 positive breast cancer cells.
Abedin MR, Powers K, Aiardo R, Barua D, Barua S
Scientific reports 2021 Apr 1;11(1):7347
Scientific reports 2021 Apr 1;11(1):7347
SOX4 promotes the growth and metastasis of breast cancer.
Zhang J, Xiao C, Feng Z, Gong Y, Sun B, Li Z, Lu Y, Fei X, Wu W, Sun X, Teng L
Cancer cell international 2020;20:468
Cancer cell international 2020;20:468
CircZFR functions as a sponge of miR-578 to promote breast cancer progression by regulating HIF1A expression.
Chen Z, Wang F, Xiong Y, Wang N, Gu Y, Qiu X
Cancer cell international 2020;20:400
Cancer cell international 2020;20:400
Treatment with galectin-1 improves myogenic potential and membrane repair in dysferlin-deficient models.
Vallecillo-Zúniga ML, Rathgeber MF, Poulson PD, Hayes S, Luddington JS, Gill HN, Teynor M, Kartchner BC, Valdoz J, Stowell C, Markham AR, Arthur C, Stowell S, Van Ry PM
PloS one 2020;15(9):e0238441
PloS one 2020;15(9):e0238441
Insulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response After Irradiation Injury.
Bohin N, McGowan KP, Keeley TM, Carlson EA, Yan KS, Samuelson LC
Cellular and molecular gastroenterology and hepatology 2020;10(4):797-810
Cellular and molecular gastroenterology and hepatology 2020;10(4):797-810
MicroRNA-33b Suppresses Epithelial-Mesenchymal Transition Repressing the MYC-EZH2 Pathway in HER2+ Breast Carcinoma.
Pattanayak B, Garrido-Cano I, Adam-Artigues A, Tormo E, Pineda B, Cabello P, Alonso E, Bermejo B, Hernando C, Martínez MT, Rovira A, Albanell J, Rojo F, Burgués O, Cejalvo JM, Lluch A, Eroles P
Frontiers in oncology 2020;10:1661
Frontiers in oncology 2020;10:1661
NVP-CGM097, an HDM2 Inhibitor, Antagonizes ATP-Binding Cassette Subfamily B Member 1-Mediated Drug Resistance.
Zhang M, Chen XY, Dong XD, Wang JQ, Feng W, Teng QX, Cui Q, Li J, Li XQ, Chen ZS
Frontiers in oncology 2020;10:1219
Frontiers in oncology 2020;10:1219
RovC - a novel type of hexameric transcriptional activator promoting type VI secretion gene expression.
Knittel V, Sadana P, Seekircher S, Stolle AS, Körner B, Volk M, Jeffries CM, Svergun DI, Heroven AK, Scrima A, Dersch P
PLoS pathogens 2020 Sep;16(9):e1008552
PLoS pathogens 2020 Sep;16(9):e1008552
Discoidin Domain Receptor 1 Regulates Runx2 during Osteogenesis of Osteoblasts and Promotes Bone Ossification via Phosphorylation of p38.
Chou LY, Chen CH, Chuang SC, Cheng TL, Lin YH, Chou HC, Fu YC, Wang YH, Wang CZ
International journal of molecular sciences 2020 Sep 29;21(19)
International journal of molecular sciences 2020 Sep 29;21(19)
The dynamic interplay between ATP/ADP levels and autophagy sustain neuronal migration in vivo.
Bressan C, Pecora A, Gagnon D, Snapyan M, Labrecque S, De Koninck P, Parent M, Saghatelyan A
eLife 2020 Sep 28;9
eLife 2020 Sep 28;9
Doxorubicin Conjugation to Reovirus Improves Oncolytic Efficacy in Triple-Negative Breast Cancer.
Berry JTL, Muñoz LE, Rodríguez Stewart RM, Selvaraj P, Mainou BA
Molecular therapy oncolytics 2020 Sep 25;18:556-572
Molecular therapy oncolytics 2020 Sep 25;18:556-572
Cell Lineage-Based Stratification for Glioblastoma.
Wang Z, Sun D, Chen YJ, Xie X, Shi Y, Tabar V, Brennan CW, Bale TA, Jayewickreme CD, Laks DR, Alcantara Llaguno S, Parada LF
Cancer cell 2020 Sep 14;38(3):366-379.e8
Cancer cell 2020 Sep 14;38(3):366-379.e8
Filgotinib suppresses HIV-1-driven gene transcription by inhibiting HIV-1 splicing and T cell activation.
Yeh YJ, Jenike KM, Calvi RM, Chiarella J, Hoh R, Deeks SG, Ho YC
The Journal of clinical investigation 2020 Sep 1;130(9):4969-4984
The Journal of clinical investigation 2020 Sep 1;130(9):4969-4984
Structure-based design, synthesis, and evaluation of the biological activity of novel phosphoroorganic small molecule IAP antagonists.
Łupicka-Słowik A, Psurski M, Grzywa R, Cuprych M, Ciekot J, Goldeman W, Wojaczyńska E, Wojaczyński J, Oleksyszyn J, Sieńczyk M
Investigational new drugs 2020 Oct;38(5):1350-1364
Investigational new drugs 2020 Oct;38(5):1350-1364
Post-translational modifications of hnRNP A1 differentially modulate retroviral IRES-mediated translation initiation.
Barrera A, Ramos H, Vera-Otarola J, Fernández-García L, Angulo J, Olguín V, Pino K, Mouland AJ, López-Lastra M
Nucleic acids research 2020 Oct 9;48(18):10479-10499
Nucleic acids research 2020 Oct 9;48(18):10479-10499
Defective Sec61α1 underlies a novel cause of autosomal dominant severe congenital neutropenia.
Van Nieuwenhove E, Barber JS, Neumann J, Smeets E, Willemsen M, Pasciuto E, Prezzemolo T, Lagou V, Seldeslachts L, Malengier-Devlies B, Metzemaekers M, Haßdenteufel S, Kerstens A, van der Kant R, Rousseau F, Schymkowitz J, Di Marino D, Lang S, Zimmermann R, Schlenner S, Munck S, Proost P, Matthys P, Devalck C, Boeckx N, Claessens F, Wouters C, Humblet-Baron S, Meyts I, Liston A
The Journal of allergy and clinical immunology 2020 Nov;146(5):1180-1193
The Journal of allergy and clinical immunology 2020 Nov;146(5):1180-1193
Rdh54/Tid1 inhibits Rad51-Rad54-mediated D-loop formation and limits D-loop length.
Shah SS, Hartono S, Piazza A, Som V, Wright W, Chédin F, Heyer WD
eLife 2020 Nov 13;9
eLife 2020 Nov 13;9
Temporal activation of WNT/β-catenin signaling is sufficient to inhibit SOX10 expression and block melanoma growth.
Uka R, Britschgi C, Krättli A, Matter C, Mihic D, Okoniewski MJ, Gualandi M, Stupp R, Cinelli P, Dummer R, Levesque MP, Shakhova O
Oncogene 2020 May;39(20):4132-4154
Oncogene 2020 May;39(20):4132-4154
Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation.
Gaub A, Sheikh BN, Basilicata MF, Vincent M, Nizon M, Colson C, Bird MJ, Bradner JE, Thevenon J, Boutros M, Akhtar A
Nature communications 2020 May 7;11(1):2243
Nature communications 2020 May 7;11(1):2243
Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway.
Duron DI, Lei W, Barker NK, Stine C, Mishra S, Blagg BSJ, Langlais PR, Streicher JM
Science signaling 2020 May 5;13(630)
Science signaling 2020 May 5;13(630)
High-throughput transcriptomic and proteomic profiling of mesenchymal-amoeboid transition in 3D collagen.
Čermák V, Gandalovičová A, Merta L, Harant K, Rösel D, Brábek J
Scientific data 2020 May 27;7(1):160
Scientific data 2020 May 27;7(1):160
Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons.
Sapiro AL, Freund EC, Restrepo L, Qiao HH, Bhate A, Li Q, Ni JQ, Mosca TJ, Li JB
Cell reports 2020 May 19;31(7):107654
Cell reports 2020 May 19;31(7):107654
Transcriptome analysis of neural progenitor cells derived from Lowe syndrome induced pluripotent stem cells: identification of candidate genes for the neurodevelopmental and eye manifestations.
Liu H, Barnes J, Pedrosa E, Herman NS, Salas F, Wang P, Zheng D, Lachman HM
Journal of neurodevelopmental disorders 2020 May 11;12(1):14
Journal of neurodevelopmental disorders 2020 May 11;12(1):14
Increased Level of Long Non-Coding RNA MALAT1 is a Common Feature of Amoeboid Invasion.
Merta L, Gandalovičová A, Čermák V, Dibus M, Gutschner T, Diederichs S, Rösel D, Brábek J
Cancers 2020 May 1;12(5)
Cancers 2020 May 1;12(5)
Steroid synthesis and metabolism in the equine placenta during placentitis.
El-Sheikh Ali H, Legacki EL, Scoggin KE, Loux SC, Dini P, Esteller-Vico A, Conley AJ, Stanley SD, Ball BA
Reproduction (Cambridge, England) 2020 Mar;159(3):289-302
Reproduction (Cambridge, England) 2020 Mar;159(3):289-302
Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement.
Matthews HK, Ganguli S, Plak K, Taubenberger AV, Win Z, Williamson M, Piel M, Guck J, Baum B
Developmental cell 2020 Mar 9;52(5):563-573.e3
Developmental cell 2020 Mar 9;52(5):563-573.e3
A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.
Chen S, Jiao L, Liu X, Yang X, Liu X
Molecular cell 2020 Mar 19;77(6):1265-1278.e7
Molecular cell 2020 Mar 19;77(6):1265-1278.e7
Adrenoceptor Expression during Intervertebral Disc Degeneration.
Kupka J, Kohler A, El Bagdadi K, Bostelmann R, Brenneis M, Fleege C, Chan D, Zaucke F, Meurer A, Rickert M, Jenei-Lanzl Z
International journal of molecular sciences 2020 Mar 18;21(6)
International journal of molecular sciences 2020 Mar 18;21(6)
A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons.
Ishizuka Y, Bramham CR
Journal of neuroscience methods 2020 Mar 1;333:108578
Journal of neuroscience methods 2020 Mar 1;333:108578
DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver.
Kronfol MM, Jahr FM, Dozmorov MG, Phansalkar PS, Xie LY, Aberg KA, McRae M, Price ET, Slattum PW, Gerk PM, McClay JL
GeroScience 2020 Jun;42(3):819-832
GeroScience 2020 Jun;42(3):819-832
Oncogenic ALK (F1174L) drives tumorigenesis in cutaneous squamous cell carcinoma.
Gualandi M, Iorio M, Engeler O, Serra-Roma A, Gasparre G, Schulte JH, Hohl D, Shakhova O
Life science alliance 2020 Jun;3(6)
Life science alliance 2020 Jun;3(6)
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.
Salazar G, Cullen A, Huang J, Zhao Y, Serino A, Hilenski L, Patrushev N, Forouzandeh F, Hwang HS
Autophagy 2020 Jun;16(6):1092-1110
Autophagy 2020 Jun;16(6):1092-1110
Rrp6 Moonlights in an RNA Exosome-Independent Manner to Promote Cell Survival and Gene Expression during Stress.
Wang C, Liu Y, DeMario SM, Mandric I, Gonzalez-Figueroa C, Chanfreau GF
Cell reports 2020 Jun 9;31(10):107754
Cell reports 2020 Jun 9;31(10):107754
Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development.
Kamata T, So TY, Ahmed Q, Giblett S, Patel B, Luo J, Reddel R, Pritchard C
Cell reports 2020 Jun 23;31(12):107802
Cell reports 2020 Jun 23;31(12):107802
The Andes Orthohantavirus NSs Protein Antagonizes the Type I Interferon Response by Inhibiting MAVS Signaling.
Vera-Otarola J, Solis L, Lowy F, Olguín V, Angulo J, Pino K, Tischler ND, Otth C, Padula P, López-Lastra M
Journal of virology 2020 Jun 16;94(13)
Journal of virology 2020 Jun 16;94(13)
The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV.
Zhao Y, Ye X, Shehata M, Dunker W, Xie Z, Karijolich J
Nature communications 2020 Jul 3;11(1):3345
Nature communications 2020 Jul 3;11(1):3345
CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity.
Patel M, Patel D, Datta S, Singh U
BMC genetics 2020 Jul 29;21(1):84
BMC genetics 2020 Jul 29;21(1):84
Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes.
Feyen DAM, McKeithan WL, Bruyneel AAN, Spiering S, Hörmann L, Ulmer B, Zhang H, Briganti F, Schweizer M, Hegyi B, Liao Z, Pölönen RP, Ginsburg KS, Lam CK, Serrano R, Wahlquist C, Kreymerman A, Vu M, Amatya PL, Behrens CS, Ranjbarvaziri S, Maas RGC, Greenhaw M, Bernstein D, Wu JC, Bers DM, Eschenhagen T, Metallo CM, Mercola M
Cell reports 2020 Jul 21;32(3):107925
Cell reports 2020 Jul 21;32(3):107925
A partially disordered region connects gene repression and activation functions of EZH2.
Jiao L, Shubbar M, Yang X, Zhang Q, Chen S, Wu Q, Chen Z, Rizo J, Liu X
Proceedings of the National Academy of Sciences of the United States of America 2020 Jul 21;117(29):16992-17002
Proceedings of the National Academy of Sciences of the United States of America 2020 Jul 21;117(29):16992-17002
Global targetome analysis reveals critical role of miR-29a in pancreatic stellate cell mediated regulation of PDAC tumor microenvironment.
Dey S, Liu S, Factora TD, Taleb S, Riverahernandez P, Udari L, Zhong X, Wan J, Kota J
BMC cancer 2020 Jul 13;20(1):651
BMC cancer 2020 Jul 13;20(1):651
Alterations of signaling pathways in response to chemical perturbations used to measure mRNA decay rates in yeast.
Eshleman N, Luo X, Capaldi A, Buchan JR
RNA (New York, N.Y.) 2020 Jan;26(1):10-18
RNA (New York, N.Y.) 2020 Jan;26(1):10-18
Cdc48/VCP and Endocytosis Regulate TDP-43 and FUS Toxicity and Turnover.
Liu G, Byrd A, Warner AN, Pei F, Basha E, Buchanan A, Buchan JR
Molecular and cellular biology 2020 Jan 30;40(4)
Molecular and cellular biology 2020 Jan 30;40(4)
Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on muscle structure and function.
Li F, Kolb J, Crudele J, Tonino P, Hourani Z, Smith JE 3rd, Chamberlain JS, Granzier H
Skeletal muscle 2020 Jan 28;10(1):2
Skeletal muscle 2020 Jan 28;10(1):2
Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.
Santos MCFD, Anderson CP, Neschen S, Zumbrennen-Bullough KB, Romney SJ, Kahle-Stephan M, Rathkolb B, Gailus-Durner V, Fuchs H, Wolf E, Rozman J, de Angelis MH, Cai WM, Rajan M, Hu J, Dedon PC, Leibold EA
Nature communications 2020 Jan 15;11(1):296
Nature communications 2020 Jan 15;11(1):296
Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model.
Babbs A, Berg A, Chatzopoulou M, Davies KE, Davies SG, Edwards B, Elsey DJ, Emer E, Figuccia ALA, Fletcher AM, Guiraud S, Harriman S, Moir L, Robinson N, Rowley JA, Russell AJ, Squire SE, Thomson JE, Tinsley JM, Wilson FX, Wynne GM
Tetrahedron 2020 Jan 10;76(2):130819
Tetrahedron 2020 Jan 10;76(2):130819
Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice.
Wang G, Xu J, Zhao J, Yin W, Liu D, Chen W, Hou SX
Nature communications 2020 Jan 10;11(1):220
Nature communications 2020 Jan 10;11(1):220
Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability.
Greenstein RA, Barrales RR, Sanchez NA, Bisanz JE, Braun S, Al-Sady B
Genes & development 2020 Jan 1;34(1-2):99-117
Genes & development 2020 Jan 1;34(1-2):99-117
Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis.
Wang G, Kostidis S, Tiemeier GL, Sol WMPJ, de Vries MR, Giera M, Carmeliet P, van den Berg BM, Rabelink TJ
Arteriosclerosis, thrombosis, and vascular biology 2020 Feb;40(2):350-364
Arteriosclerosis, thrombosis, and vascular biology 2020 Feb;40(2):350-364
A1 adenosine receptor signaling reduces Streptococcus pneumoniae adherence to pulmonary epithelial cells by targeting expression of platelet-activating factor receptor.
Bhalla M, Hui Yeoh J, Lamneck C, Herring SE, Tchalla EYI, Heinzinger LR, Leong JM, Bou Ghanem EN
Cellular microbiology 2020 Feb;22(2):e13141
Cellular microbiology 2020 Feb;22(2):e13141
miR-29a Is Repressed by MYC in Pancreatic Cancer and Its Restoration Drives Tumor-Suppressive Effects via Downregulation of LOXL2.
Dey S, Kwon JJ, Liu S, Hodge GA, Taleb S, Zimmers TA, Wan J, Kota J
Molecular cancer research : MCR 2020 Feb;18(2):311-323
Molecular cancer research : MCR 2020 Feb;18(2):311-323
Schizosaccharomyces pombe DNA translocases Rrp1 and Rrp2 have distinct roles at centromeres and telomeres that ensure genome stability.
Barg-Wojas A, Muraszko J, Kramarz K, Schirmeisen K, Baranowska G, Carr AM, Dziadkowiec D
Journal of cell science 2020 Feb 10;133(3)
Journal of cell science 2020 Feb 10;133(3)
Age-dependent changes in electrophysiology and calcium handling: implications for pediatric cardiac research.
Swift LM, Burke M, Guerrelli D, Reilly M, Ramadan M, McCullough D, Prudencio T, Mulvany C, Chaluvadi A, Jaimes R, Posnack NG
American journal of physiology. Heart and circulatory physiology 2020 Feb 1;318(2):H354-H365
American journal of physiology. Heart and circulatory physiology 2020 Feb 1;318(2):H354-H365
Progressive cardiac arrhythmias and ECG abnormalities in the Huntington's disease BACHD mouse model.
Zhu Y, Shamblin I, Rodriguez E, Salzer GE, Araysi L, Margolies KA, Halade GV, Litovsky SH, Pogwizd S, Gray M, Huke S
Human molecular genetics 2020 Feb 1;29(3):369-381
Human molecular genetics 2020 Feb 1;29(3):369-381
Striated Preferentially Expressed Protein Kinase (SPEG)-Deficient Skeletal Muscles Display Fewer Satellite Cells with Reduced Proliferation and Delayed Differentiation.
Li Q, Lin J, Rosen SM, Zhang T, Kazerounian S, Luo S, Agrawal PB
The American journal of pathology 2020 Dec;190(12):2453-2463
The American journal of pathology 2020 Dec;190(12):2453-2463
Promoting roles of long non-coding RNA FAM83H-AS1 in bladder cancer growth, metastasis, and angiogenesis through the c-Myc-mediated ULK3 upregulation.
Liu B, Gao W, Sun W, Li L, Wang C, Yang X, Liu J, Guo Y
Cell cycle (Georgetown, Tex.) 2020 Dec;19(24):3546-3562
Cell cycle (Georgetown, Tex.) 2020 Dec;19(24):3546-3562
Bacteria elevate extracellular adenosine to exploit host signaling for blood-brain barrier disruption.
Zhao Z, Shang X, Chen Y, Zheng Y, Huang W, Jiang H, Lv Q, Kong D, Jiang Y, Liu P
Virulence 2020 Dec;11(1):980-994
Virulence 2020 Dec;11(1):980-994
Local Targeting of Lung-Tumor-Associated Macrophages with Pulmonary Delivery of a CSF-1R Inhibitor for the Treatment of Breast Cancer Lung Metastases.
Alhudaithi SS, Almuqbil RM, Zhang H, Bielski ER, Du W, Sunbul FS, Bos PD, da Rocha SRP
Molecular pharmaceutics 2020 Dec 7;17(12):4691-4703
Molecular pharmaceutics 2020 Dec 7;17(12):4691-4703
LINC00460-miR-149-5p/miR-150-5p-Mutant p53 Feedback Loop Promotes Oxaliplatin Resistance in Colorectal Cancer.
Meng X, Sun W, Yu J, Zhou Y, Gu Y, Han J, Zhou L, Jiang X, Wang C
Molecular therapy. Nucleic acids 2020 Dec 4;22:1004-1015
Molecular therapy. Nucleic acids 2020 Dec 4;22:1004-1015
Mucin-2 knockout is a model of intercellular junction defects, mitochondrial damage and ATP depletion in the intestinal epithelium.
Borisova MA, Achasova KM, Morozova KN, Andreyeva EN, Litvinova EA, Ogienko AA, Morozova MV, Berkaeva MB, Kiseleva E, Kozhevnikova EN
Scientific reports 2020 Dec 3;10(1):21135
Scientific reports 2020 Dec 3;10(1):21135
Isolation and Characterization of primary human trabecular meshwork cells from segmental flow regions: New tools for understanding segmental flow.
Staverosky J, Dhamodaran K, Acott T, Raghunathan V, Vranka J
Experimental eye research 2020 Aug;197:108046
Experimental eye research 2020 Aug;197:108046
Involvement of Differentially Expressed microRNAs in the PEGylated Liposome Encapsulated (188)Rhenium-Mediated Suppression of Orthotopic Hypopharyngeal Tumor.
Lin BZ, Wan SY, Lin MY, Chang CH, Chen TW, Yang MH, Lee YJ
Molecules (Basel, Switzerland) 2020 Aug 8;25(16)
Molecules (Basel, Switzerland) 2020 Aug 8;25(16)
Mechanism and Function of Antiviral RNA Interference in Mice.
Han Q, Chen G, Wang J, Jee D, Li WX, Lai EC, Ding SW
mBio 2020 Aug 4;11(4)
mBio 2020 Aug 4;11(4)
Sustained Inflammatory Signalling through Stat1/Stat2/IRF9 Is Associated with Amoeboid Phenotype of Melanoma Cells.
Gandalovičová A, Šůchová AM, Čermák V, Merta L, Rösel D, Brábek J
Cancers 2020 Aug 28;12(9)
Cancers 2020 Aug 28;12(9)
A Novel CD147 Inhibitor, SP-8356, Attenuates Pathological Fibrosis in Alkali-Burned Rat Cornea.
Joung C, Noh H, Jung J, Song HY, Bae H, Pahk K, Kim WK
International journal of molecular sciences 2020 Apr 23;21(8)
International journal of molecular sciences 2020 Apr 23;21(8)
Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration.
Fragola G, Mabb AM, Taylor-Blake B, Niehaus JK, Chronister WD, Mao H, Simon JM, Yuan H, Li Z, McConnell MJ, Zylka MJ
Nature communications 2020 Apr 23;11(1):1962
Nature communications 2020 Apr 23;11(1):1962
VEGF Treatment Ameliorates Depression-Like Behavior in Adult Offspring After Maternal Immune Activation.
Sideromenos S, Lindtner C, Zambon A, Horvath O, Berger A, Pollak DD
Cells 2020 Apr 22;9(4)
Cells 2020 Apr 22;9(4)
Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study.
Ji N, Yang Y, Cai CY, Wang JQ, Lei ZN, Wu ZX, Cui Q, Yang DH, Chen ZS, Kong D
Frontiers in oncology 2019;9:514
Frontiers in oncology 2019;9:514
Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells.
Cui Q, Cai CY, Gao HL, Ren L, Ji N, Gupta P, Yang Y, Shukla S, Ambudkar SV, Yang DH, Chen ZS
Frontiers in oncology 2019;9:313
Frontiers in oncology 2019;9:313
Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.
Cansby E, Nuñez-Durán E, Magnusson E, Amrutkar M, Booten SL, Kulkarni NM, Svensson LT, Borén J, Marschall HU, Aghajan M, Mahlapuu M
Cellular and molecular gastroenterology and hepatology 2019;7(3):597-618
Cellular and molecular gastroenterology and hepatology 2019;7(3):597-618
The Influence of Pro-Inflammatory Factors on Sclerostin and Dickkopf-1 Production in Human Dental Pulp Cells Under Hypoxic Conditions.
Janjić K, Samiei M, Moritz A, Agis H
Frontiers in bioengineering and biotechnology 2019;7:430
Frontiers in bioengineering and biotechnology 2019;7:430
miR-98 Modulates Cytokine Production from Human PBMCs in Systemic Lupus Erythematosus by Targeting IL-6 mRNA.
Yuan S, Tang C, Chen D, Li F, Huang M, Ye J, He Z, Li W, Chen Y, Lin X, Wang X, Cai X
Journal of immunology research 2019;2019:9827574
Journal of immunology research 2019;2019:9827574
Placental Expression of NEMO Protein in Normal Pregnancy and Preeclampsia.
Sakowicz A, Lisowska M, Biesiada L, Płuciennik E, Gach A, Rybak-Krzyszkowska M, Huras H, Sakowicz B, Romanowicz H, Piastowska-Ciesielska AW, Grzesiak M, Pietrucha T
Disease markers 2019;2019:8418379
Disease markers 2019;2019:8418379
Enhanced Activity by NKCC1 and Slc26a6 Mediates Acidic pH and Cl(-) Movement after Cardioplegia-Induced Arrest of db/db Diabetic Heart.
Ji M, In Lee S, Lee SA, Son KH, Hong JH
Mediators of inflammation 2019;2019:7583760
Mediators of inflammation 2019;2019:7583760
Expression of mutant mRNA and protein in pancreatic cells derived from MODY3- iPS cells.
Yabe SG, Nishida J, Fukuda S, Takeda F, Nasiro K, Yasuda K, Iwasaki N, Okochi H
PloS one 2019;14(5):e0217110
PloS one 2019;14(5):e0217110
SLMAP3 isoform modulates cardiac gene expression and function.
Mlynarova J, Trentin-Sonoda M, Gaisler da Silva F, Major JL, Salih M, Carneiro-Ramos MS, Tuana BS
PloS one 2019;14(4):e0214669
PloS one 2019;14(4):e0214669
Mechano-signalling, induced by fullerene C(60) nanofilms, arrests the cell cycle in the G2/M phase and decreases proliferation of liver cancer cells.
Sosnowska M, Kutwin M, Jaworski S, Strojny B, Wierzbicki M, Szczepaniak J, Łojkowski M, Święszkowski W, Bałaban J, Chwalibog A, Sawosz E
International journal of nanomedicine 2019;14:6197-6215
International journal of nanomedicine 2019;14:6197-6215
Minor ginsenoside F1 improves memory in APP/PS1 mice.
Han J, Oh JP, Yoo M, Cui CH, Jeon BM, Kim SC, Han JH
Molecular brain 2019 Sep 5;12(1):77
Molecular brain 2019 Sep 5;12(1):77
Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.
Chen Z, Picaud S, Filippakopoulos P, D'Angiolella V, Bullock AN
Structure (London, England : 1993) 2019 Sep 3;27(9):1395-1404.e4
Structure (London, England : 1993) 2019 Sep 3;27(9):1395-1404.e4
A ribose-functionalized NAD(+) with unexpected high activity and selectivity for protein poly-ADP-ribosylation.
Zhang XN, Cheng Q, Chen J, Lam AT, Lu Y, Dai Z, Pei H, Evdokimov NM, Louie SG, Zhang Y
Nature communications 2019 Sep 13;10(1):4196
Nature communications 2019 Sep 13;10(1):4196
Chia (Salvia hispanica L.) Seed Total Protein and Protein Fractions Digests Reduce Biomarkers of Inflammation and Atherosclerosis in Macrophages In Vitro.
Grancieri M, Martino HSD, Gonzalez de Mejia E
Molecular nutrition & food research 2019 Oct;63(19):e1900021
Molecular nutrition & food research 2019 Oct;63(19):e1900021
Angiopoietin-like 4 production upon treatment with hypoxia and L-mimosine in periodontal fibroblasts.
Janjić K, Schellner A, Engenhart A, Kernstock K, Schädl B, Moritz A, Agis H
Journal of periodontal research 2019 Oct;54(5):489-498
Journal of periodontal research 2019 Oct;54(5):489-498
Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.
Sinden DS, Holman CD, Bare CJ, Sun X, Gade AR, Cohen DE, Pitt GS
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Oct;33(10):11579-11594
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Oct;33(10):11579-11594
Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the heterotrimer.
Chen KY, Santos Afonso ED, Enouf V, Isel C, Naffakh N
PLoS pathogens 2019 Oct;15(10):e1008034
PLoS pathogens 2019 Oct;15(10):e1008034
Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies.
Alexaki A, Hettiarachchi GK, Athey JC, Katneni UK, Simhadri V, Hamasaki-Katagiri N, Nanavaty P, Lin B, Takeda K, Freedberg D, Monroe D, McGill JR, Peters R, Kames JM, Holcomb DD, Hunt RC, Sauna ZE, Gelinas A, Janjic N, DiCuccio M, Bar H, Komar AA, Kimchi-Sarfaty C
Scientific reports 2019 Oct 29;9(1):15449
Scientific reports 2019 Oct 29;9(1):15449
N-Dihydrogalactochitosan Potentiates the Radiosensitivity of Liver Metastatic Tumor Cells Originated from Murine Breast Tumors.
Wang CY, Chang CY, Wang CY, Liu K, Kang CY, Lee YJ, Chen WR
International journal of molecular sciences 2019 Nov 8;20(22)
International journal of molecular sciences 2019 Nov 8;20(22)
Reversible Disruption of Specific Transcription Factor-DNA Interactions Using CRISPR/Cas9.
Shariati SA, Dominguez A, Xie S, Wernig M, Qi LS, Skotheim JM
Molecular cell 2019 May 2;74(3):622-633.e4
Molecular cell 2019 May 2;74(3):622-633.e4
Inhibition of MYC by the SMARCB1 tumor suppressor.
Weissmiller AM, Wang J, Lorey SL, Howard GC, Martinez E, Liu Q, Tansey WP
Nature communications 2019 May 1;10(1):2014
Nature communications 2019 May 1;10(1):2014
Role and mechanism of nursing cooperation and tetramethylpyrazine application in post-operative pain in patients undergoing total knee arthroplasty.
Liu C, Liu R, Tang M, Yang X, Gong X
Experimental and therapeutic medicine 2019 Mar;17(3):2366-2372
Experimental and therapeutic medicine 2019 Mar;17(3):2366-2372
An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease.
Mäkeläinen S, Gòdia M, Hellsand M, Viluma A, Hahn D, Makdoumi K, Zeiss CJ, Mellersh C, Ricketts SL, Narfström K, Hallböök F, Ekesten B, Andersson G, Bergström TF
PLoS genetics 2019 Mar;15(3):e1007873
PLoS genetics 2019 Mar;15(3):e1007873
The miRNA-449 family mediates doxorubicin resistance in triple-negative breast cancer by regulating cell cycle factors.
Tormo E, Ballester S, Adam-Artigues A, Burgués O, Alonso E, Bermejo B, Menéndez S, Zazo S, Madoz-Gúrpide J, Rovira A, Albanell J, Rojo F, Lluch A, Eroles P
Scientific reports 2019 Mar 29;9(1):5316
Scientific reports 2019 Mar 29;9(1):5316
Role of Norepinephrine in IL-1β-Induced Chondrocyte Dedifferentiation under Physioxia.
Speichert S, Molotkov N, El Bagdadi K, Meurer A, Zaucke F, Jenei-Lanzl Z
International journal of molecular sciences 2019 Mar 11;20(5)
International journal of molecular sciences 2019 Mar 11;20(5)
Quantitative Proteomics Links the Intermediate Filament Nestin to Resistance to Targeted BRAF Inhibition in Melanoma Cells.
Schmitt M, Sinnberg T, Nalpas NC, Maass A, Schittek B, Macek B
Molecular & cellular proteomics : MCP 2019 Jun;18(6):1096-1109
Molecular & cellular proteomics : MCP 2019 Jun;18(6):1096-1109
CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release.
Ajasin DO, Rao VR, Wu X, Ramasamy S, Pujato M, Ruiz AP, Fiser A, Bresnick AR, Kalpana GV, Prasad VR
eLife 2019 Jun 7;8
eLife 2019 Jun 7;8
Norepinephrine Inhibits Synovial Adipose Stem Cell Chondrogenesis via α2a-Adrenoceptor-Mediated ERK1/2 Activation.
El Bagdadi K, Zaucke F, Meurer A, Straub RH, Jenei-Lanzl Z
International journal of molecular sciences 2019 Jun 26;20(13)
International journal of molecular sciences 2019 Jun 26;20(13)
Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder.
Tang S, Terzic B, Wang IJ, Sarmiento N, Sizov K, Cui Y, Takano H, Marsh ED, Zhou Z, Coulter DA
Nature communications 2019 Jun 14;10(1):2655
Nature communications 2019 Jun 14;10(1):2655
Sex differences in nicotine-enhanced Pavlovian conditioned approach in rats.
Stringfield SJ, Madayag AC, Boettiger CA, Robinson DL
Biology of sex differences 2019 Jul 17;10(1):37
Biology of sex differences 2019 Jul 17;10(1):37
MicroRNA-421-targeted PDCD4 regulates breast cancer cell proliferation.
Wang Y, Liu Z, Shen J
International journal of molecular medicine 2019 Jan;43(1):267-275
International journal of molecular medicine 2019 Jan;43(1):267-275
Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1.
Kodan A, Yamaguchi T, Nakatsu T, Matsuoka K, Kimura Y, Ueda K, Kato H
Nature communications 2019 Jan 8;10(1):88
Nature communications 2019 Jan 8;10(1):88
Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection.
Dagur RS, Branch-Woods A, Mathews S, Joshi PS, Quadros RM, Harms DW, Cheng Y, Miles SM, Pirruccello SJ, Gurumurthy CB, Gorantla S, Poluektova LY
BMC immunology 2019 Jan 7;20(1):2
BMC immunology 2019 Jan 7;20(1):2
Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism.
Rosina E, Battan B, Siracusano M, Di Criscio L, Hollis F, Pacini L, Curatolo P, Bagni C
Translational psychiatry 2019 Jan 31;9(1):50
Translational psychiatry 2019 Jan 31;9(1):50
Development of Highly Sensitive Biosensors of RAF Dimerization in Cells.
Miyamoto K, Sawa M
Scientific reports 2019 Jan 24;9(1):636
Scientific reports 2019 Jan 24;9(1):636
High LET Radiation Overcomes In Vitro Resistance to X-Rays of Chondrosarcoma Cell Lines.
Chevalier F, Hamdi DH, Lepleux C, Temelie M, Nicol A, Austry JB, Lesueur P, Vares G, Savu D, Nakajima T, Saintigny Y
Technology in cancer research & treatment 2019 Jan 1;18:1533033819871309
Technology in cancer research & treatment 2019 Jan 1;18:1533033819871309
Deacetylation Inhibition Reverses PABPN1-Dependent Muscle Wasting.
Olie CS, Riaz M, Konietzny R, Charles PD, Pinto-Fernandez A, Kiełbasa SM, Aartsma-Rus A, Goeman JJ, Kessler BM, Raz V
iScience 2019 Feb 22;12:318-332
iScience 2019 Feb 22;12:318-332
A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP.
Lobas MA, Tao R, Nagai J, Kronschläger MT, Borden PM, Marvin JS, Looger LL, Khakh BS
Nature communications 2019 Feb 12;10(1):711
Nature communications 2019 Feb 12;10(1):711
Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling.
Mesmar F, Dai B, Ibrahim A, Hases L, Jafferali MH, Jose Augustine J, DiLorenzo S, Kang Y, Zhao Y, Wang J, Kim M, Lin CY, Berkenstam A, Fleming J, Williams C
Cancer medicine 2019 Dec;8(18):7705-7719
Cancer medicine 2019 Dec;8(18):7705-7719
Therapeutic Effects of Nrf2 Activation by Bardoxolone Methyl in Chronic Heart Failure.
Tian C, Gao L, Zhang A, Hackfort BT, Zucker IH
The Journal of pharmacology and experimental therapeutics 2019 Dec;371(3):642-651
The Journal of pharmacology and experimental therapeutics 2019 Dec;371(3):642-651
Coxiella burnetii Type 4B Secretion System-dependent manipulation of endolysosomal maturation is required for bacterial growth.
Samanta D, Clemente TM, Schuler BE, Gilk SD
PLoS pathogens 2019 Dec;15(12):e1007855
PLoS pathogens 2019 Dec;15(12):e1007855
Loss of methionine sulfoxide reductases increases resistance to oxidative stress.
Lai L, Sun J, Tarafdar S, Liu C, Murphy E, Kim G, Levine RL
Free radical biology & medicine 2019 Dec;145:374-384
Free radical biology & medicine 2019 Dec;145:374-384
PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism.
Stine RR, Sakers AP, TeSlaa T, Kissig M, Stine ZE, Kwon CW, Cheng L, Lim HW, Kaestner KH, Rabinowitz JD, Seale P
Cell stem cell 2019 Dec 5;25(6):830-845.e8
Cell stem cell 2019 Dec 5;25(6):830-845.e8
Peri-adolescent alcohol consumption increases sensitivity and dopaminergic response to nicotine during adulthood in female alcohol-preferring (P) rats: Alterations to α7 nicotinic acetylcholine receptor expression.
Waeiss RA, Knight CP, Carvajal GB, Bell RL, Engleman EA, McBride WJ, Hauser SR, Rodd ZA
Behavioural brain research 2019 Dec 30;376:112190
Behavioural brain research 2019 Dec 30;376:112190
Enhanced Killing of Triple-Negative Breast Cancer Cells by Reassortant Reovirus and Topoisomerase Inhibitors.
Rodríguez Stewart RM, Berry JTL, Berger AK, Yoon SB, Hirsch AL, Guberman JA, Patel NB, Tharp GK, Bosinger SE, Mainou BA
Journal of virology 2019 Dec 1;93(23)
Journal of virology 2019 Dec 1;93(23)
OBG-like ATPase 1 inhibition attenuates angiotensin II-induced hypertrophic response in human ventricular myocytes via GSK-3beta/beta-catenin signalling.
Narasimhan G, Henderson J, Luong HT, Rajasekaran NS, Qin G, Zhang J, Krishnamurthy P
Clinical and experimental pharmacology & physiology 2019 Aug;46(8):743-751
Clinical and experimental pharmacology & physiology 2019 Aug;46(8):743-751
Development of a Molecularly Stable Gene Therapy Vector for the Treatment of RPGR-Associated X-Linked Retinitis Pigmentosa.
Giacalone JC, Andorf JL, Zhang Q, Burnight ER, Ochoa D, Reutzel AJ, Collins MM, Sheffield VC, Mullins RF, Han IC, Stone EM, Tucker BA
Human gene therapy 2019 Aug;30(8):967-974
Human gene therapy 2019 Aug;30(8):967-974
Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK.
Gross AS, Zimmermann A, Pendl T, Schroeder S, Schoenlechner H, Knittelfelder O, Lamplmayr L, Santiso A, Aufschnaiter A, Waltenstorfer D, Ortonobes Lara S, Stryeck S, Kast C, Ruckenstuhl C, Hofer SJ, Michelitsch B, Woelflingseder M, Müller R, Carmona-Gutierrez D, Madl T, Büttner S, Fröhlich KU, Shevchenko A, Eisenberg T
The Journal of biological chemistry 2019 Aug 9;294(32):12020-12039
The Journal of biological chemistry 2019 Aug 9;294(32):12020-12039
Molecular imaging of endothelial activation and mineralization in a mouse model of accelerated atherosclerosis.
Rucher G, Cameliere L, Fendri J, Anfray A, Abbas A, Kamel S, Dupas Q, Delcroix N, Berger L, Manrique A, STOP-AS investigators
EJNMMI research 2019 Aug 22;9(1):80
EJNMMI research 2019 Aug 22;9(1):80
Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells.
Cui Q, Cai CY, Wang JQ, Zhang S, Gupta P, Ji N, Yang Y, Dong X, Yang DH, Chen ZS
International journal of molecular sciences 2019 Aug 22;20(17)
International journal of molecular sciences 2019 Aug 22;20(17)
Zika Virus Production Is Resistant to RNase L Antiviral Activity.
Whelan JN, Li Y, Silverman RH, Weiss SR
Journal of virology 2019 Aug 15;93(16)
Journal of virology 2019 Aug 15;93(16)
Restoration of primary cilia in obese adipose-derived mesenchymal stem cells by inhibiting Aurora A or extracellular signal-regulated kinase.
Ritter A, Kreis NN, Roth S, Friemel A, Jennewein L, Eichbaum C, Solbach C, Louwen F, Yuan J
Stem cell research & therapy 2019 Aug 14;10(1):255
Stem cell research & therapy 2019 Aug 14;10(1):255
Role of forward and reverse signaling in Eph receptor and ephrin mediated cell segregation.
Wu Z, Ashlin TG, Xu Q, Wilkinson DG
Experimental cell research 2019 Aug 1;381(1):57-65
Experimental cell research 2019 Aug 1;381(1):57-65
A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation.
Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M
Journal of proteome research 2019 Apr 5;18(4):1607-1622
Journal of proteome research 2019 Apr 5;18(4):1607-1622
Aspirin impairs acetyl-coenzyme A metabolism in redox-compromised yeast cells.
Farrugia G, Azzopardi M, Saliba C, Grech G, Gross AS, Pistolic J, Benes V, Vassallo N, Borg J, Madeo F, Eisenberg T, Balzan R
Scientific reports 2019 Apr 16;9(1):6152
Scientific reports 2019 Apr 16;9(1):6152
Complement Component 3 Negatively Regulates Antibody Response by Modulation of Red Blood Cell Antigen.
Mener A, Arthur CM, Patel SR, Liu J, Hendrickson JE, Stowell SR
Frontiers in immunology 2018;9:676
Frontiers in immunology 2018;9:676
VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters.
Ji N, Yang Y, Cai CY, Lei ZN, Wang JQ, Gupta P, Teng QX, Chen ZS, Kong D, Yang DH
Frontiers in pharmacology 2018;9:1236
Frontiers in pharmacology 2018;9:1236
Organic Solute Transporter α-β Protects Ileal Enterocytes From Bile Acid-Induced Injury.
Ferrebee CB, Li J, Haywood J, Pachura K, Robinson BS, Hinrichs BH, Jones RM, Rao A, Dawson PA
Cellular and molecular gastroenterology and hepatology 2018;5(4):499-522
Cellular and molecular gastroenterology and hepatology 2018;5(4):499-522
PEGylated liposome-encapsulated rhenium-188 radiopharmaceutical inhibits proliferation and epithelial-mesenchymal transition of human head and neck cancer cells in vivo with repeated therapy.
Chang CY, Chen CC, Lin LT, Chang CH, Chen LC, Wang HE, Lee TW, Lee YJ
Cell death discovery 2018;4:100
Cell death discovery 2018;4:100
Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases.
Kauffman KJ, Yu S, Jin J, Mugo B, Nguyen N, O'Brien A, Nag S, Lystad AH, Melia TJ
Autophagy 2018;14(6):992-1010
Autophagy 2018;14(6):992-1010
Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux.
Wang K, Zhang T, Lei Y, Li X, Jiang J, Lan J, Liu Y, Chen H, Gao W, Xie N, Chen Q, Zhu X, Liu X, Xie K, Peng Y, Nice EC, Wu M, Huang C, Wei Y
Autophagy 2018;14(2):269-282
Autophagy 2018;14(2):269-282
Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6(S10F) mutant.
Liu GS, Zhu H, Cai WF, Wang X, Jiang M, Essandoh K, Vafiadaki E, Haghighi K, Lam CK, Gardner G, Adly G, Nicolaou P, Sanoudou D, Liang Q, Rubinstein J, Fan GC, Kranias EG
Autophagy 2018;14(1):80-97
Autophagy 2018;14(1):80-97
Altering lipid droplet homeostasis affects Coxiella burnetii intracellular growth.
Mulye M, Zapata B, Gilk SD
PloS one 2018;13(2):e0192215
PloS one 2018;13(2):e0192215
Herpes Simplex Virus Type 1 Enhances Expression of the Synaptic Protein Arc for Its Own Benefit.
Acuña-Hinrichsen F, Muñoz M, Hott M, Martin C, Mancilla E, Salazar P, Leyton L, Zambrano A, Concha MI, Burgos PV, Otth C
Frontiers in cellular neuroscience 2018;12:505
Frontiers in cellular neuroscience 2018;12:505
Melittin induces NSCLC apoptosis via inhibition of miR-183.
Gao D, Zhang J, Bai L, Li F, Dong Y, Li Q
OncoTargets and therapy 2018;11:4511-4523
OncoTargets and therapy 2018;11:4511-4523
The Enzymatic Core of the Parkinson's Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast.
Aufschnaiter A, Kohler V, Walter C, Tosal-Castano S, Habernig L, Wolinski H, Keller W, Vögtle FN, Büttner S
Frontiers in molecular neuroscience 2018;11:205
Frontiers in molecular neuroscience 2018;11:205
Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα Is Neuroprotective.
Suresh SN, Chavalmane AK, Pillai M, Ammanathan V, Vidyadhara DJ, Yarreiphang H, Rai S, Paul A, Clement JP, Alladi PA, Manjithaya R
Frontiers in molecular neuroscience 2018;11:109
Frontiers in molecular neuroscience 2018;11:109
miRNA-218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3.
Zhang J, Li S, Li Y, Liu H, Zhang Y, Zhang Q
Experimental and therapeutic medicine 2018 Sep;16(3):2433-2441
Experimental and therapeutic medicine 2018 Sep;16(3):2433-2441
Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection.
Chow TT, Shi X, Wei JH, Guan J, Stadler G, Huang B, Blackburn EH
Nature communications 2018 Sep 4;9(1):3583
Nature communications 2018 Sep 4;9(1):3583
Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.
Nguyen TL, Duchon A, Manousopoulou A, Loaëc N, Villiers B, Pani G, Karatas M, Mechling AE, Harsan LA, Limanton E, Bazureau JP, Carreaux F, Garbis SD, Meijer L, Herault Y
Disease models & mechanisms 2018 Sep 27;11(9)
Disease models & mechanisms 2018 Sep 27;11(9)
Apoptotic efficacy of multifaceted biosynthesized silver nanoparticles on human adenocarcinoma cells.
Plackal Adimuriyil George B, Kumar N, Abrahamse H, Ray SS
Scientific reports 2018 Sep 25;8(1):14368
Scientific reports 2018 Sep 25;8(1):14368
Inhibition of Bacterial Gene Transcription with an RpoN-Based Stapled Peptide.
Payne SR, Pau DI, Whiting AL, Kim YJ, Pharoah BM, Moi C, Boddy CN, Bernal F
Cell chemical biology 2018 Sep 20;25(9):1059-1066.e4
Cell chemical biology 2018 Sep 20;25(9):1059-1066.e4
Genetic Reduction or Negative Modulation of mGlu(7) Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome.
Fisher NM, Gogliotti RG, Vermudez SAD, Stansley BJ, Conn PJ, Niswender CM
ACS chemical neuroscience 2018 Sep 19;9(9):2210-2217
ACS chemical neuroscience 2018 Sep 19;9(9):2210-2217
Transforming growth factor β1 suppresses proinflammatory gene program independent of its regulation on vascular smooth muscle differentiation and autophagy.
Gao P, Wu W, Ye J, Lu YW, Adam AP, Singer HA, Long X
Cellular signalling 2018 Oct;50:160-170
Cellular signalling 2018 Oct;50:160-170
The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy.
Makarewich CA, Munir AZ, Schiattarella GG, Bezprozvannaya S, Raguimova ON, Cho EE, Vidal AH, Robia SL, Bassel-Duby R, Olson EN
eLife 2018 Oct 9;7
eLife 2018 Oct 9;7
RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.
Bradley T, Peppa D, Pedroza-Pacheco I, Li D, Cain DW, Henao R, Venkat V, Hora B, Chen Y, Vandergrift NA, Overman RG, Edwards RW, Woods CW, Tomaras GD, Ferrari G, Ginsburg GS, Connors M, Cohen MS, Moody MA, Borrow P, Haynes BF
Cell 2018 Oct 4;175(2):387-399.e17
Cell 2018 Oct 4;175(2):387-399.e17
Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation.
de la Roche M, Hamilton C, Mortensen R, Jeyaprakash AA, Ghosh S, Anand PK
The Journal of cell biology 2018 Oct 1;217(10):3560-3576
The Journal of cell biology 2018 Oct 1;217(10):3560-3576
Obesity-Activated Adipose-Derived Stromal Cells Promote Breast Cancer Growth and Invasion.
Hillers LE, D'Amato JV, Chamberlin T, Paderta G, Arendt LM
Neoplasia (New York, N.Y.) 2018 Nov;20(11):1161-1174
Neoplasia (New York, N.Y.) 2018 Nov;20(11):1161-1174
The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity.
Sluder IT, Nitika, Knighton LE, Truman AW
PLoS genetics 2018 Nov;14(11):e1007462
PLoS genetics 2018 Nov;14(11):e1007462
HEXIM1-Tat chimera inhibits HIV-1 replication.
Leoz M, Kukanja P, Luo Z, Huang F, Cary DC, Peterlin BM, Fujinaga K
PLoS pathogens 2018 Nov;14(11):e1007402
PLoS pathogens 2018 Nov;14(11):e1007402
Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells.
Klinngam W, Fu R, Janga SR, Edman MC, Hamm-Alvarez SF
International journal of molecular sciences 2018 Nov 9;19(11)
International journal of molecular sciences 2018 Nov 9;19(11)
RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection.
Zhao Y, Ye X, Dunker W, Song Y, Karijolich J
Nature communications 2018 Nov 19;9(1):4841
Nature communications 2018 Nov 19;9(1):4841
Phage-Antibiotic Synergy via Delayed Lysis.
Kim M, Jo Y, Hwang YJ, Hong HW, Hong SS, Park K, Myung H
Applied and environmental microbiology 2018 Nov 15;84(22)
Applied and environmental microbiology 2018 Nov 15;84(22)
Antibody-mediated immune suppression by antigen modulation is antigen-specific.
Maier CL, Mener A, Patel SR, Jajosky RP, Bennett AL, Arthur CM, Hendrickson JE, Stowell SR
Blood advances 2018 Nov 13;2(21):2986-3000
Blood advances 2018 Nov 13;2(21):2986-3000
Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor.
Groenendyk J, Paskevicius T, Urra H, Viricel C, Wang K, Barakat K, Hetz C, Kurgan L, Agellon LB, Michalak M
Scientific reports 2018 Nov 12;8(1):16678
Scientific reports 2018 Nov 12;8(1):16678
ATM‑JAK‑PD‑L1 signaling pathway inhibition decreases EMT and metastasis of androgen‑independent prostate cancer.
Zhang L, Xu LJ, Zhu J, Li J, Xue BX, Gao J, Sun CY, Zang YC, Zhou YB, Yang DR, Shan YX
Molecular medicine reports 2018 May;17(5):7045-7054
Molecular medicine reports 2018 May;17(5):7045-7054
Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6.
Vanaja GR, Ramulu HG, Kalle AM
Cell communication and signaling : CCS 2018 May 2;16(1):20
Cell communication and signaling : CCS 2018 May 2;16(1):20
Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype.
Terlecki-Zaniewicz L, Lämmermann I, Latreille J, Bobbili MR, Pils V, Schosserer M, Weinmüllner R, Dellago H, Skalicky S, Pum D, Almaraz JCH, Scheideler M, Morizot F, Hackl M, Gruber F, Grillari J
Aging 2018 May 19;10(5):1103-1132
Aging 2018 May 19;10(5):1103-1132
Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease.
Wang L, Xia J, Li J, Hagemann TL, Jones JR, Fraenkel E, Weitz DA, Zhang SC, Messing A, Feany MB
Nature communications 2018 May 15;9(1):1899
Nature communications 2018 May 15;9(1):1899
Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures.
Janjić K, Cvikl B, Kurzmann C, Moritz A, Agis H
BMC oral health 2018 Mar 9;18(1):36
BMC oral health 2018 Mar 9;18(1):36
AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity.
Brolih S, Parks SK, Vial V, Durivault J, Mostosi L, Pouysségur J, Pagès G, Picco V
BMC cancer 2018 Mar 5;18(1):249
BMC cancer 2018 Mar 5;18(1):249
miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells.
Flum M, Kleemann M, Schneider H, Weis B, Fischer S, Handrick R, Otte K
Journal of cell communication and signaling 2018 Jun;12(2):451-466
Journal of cell communication and signaling 2018 Jun;12(2):451-466
Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility.
Igarashi A, Itoh K, Yamada T, Adachi Y, Kato T, Murata D, Sesaki H, Iijima M
The Journal of biological chemistry 2018 Jun 15;293(24):9292-9300
The Journal of biological chemistry 2018 Jun 15;293(24):9292-9300
MiR-744-5p inducing cell death by directly targeting HNRNPC and NFIX in ovarian cancer cells.
Kleemann M, Schneider H, Unger K, Sander P, Schneider EM, Fischer-Posovszky P, Handrick R, Otte K
Scientific reports 2018 Jun 13;8(1):9020
Scientific reports 2018 Jun 13;8(1):9020
SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity.
Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton BN, Chang L, Liu N, Zeng L, Wang W, Wang Y, Zhang P, Hu X, Su X, Liang H, Sun Y, Ma L
Nature communications 2018 Jun 11;9(1):2269
Nature communications 2018 Jun 11;9(1):2269
Overexpression of hexokinase 2 reduces mitochondrial calcium overload in coronary endothelial cells of type 2 diabetic mice.
Pan M, Han Y, Basu A, Dai A, Si R, Willson C, Balistrieri A, Scott BT, Makino A
American journal of physiology. Cell physiology 2018 Jun 1;314(6):C732-C740
American journal of physiology. Cell physiology 2018 Jun 1;314(6):C732-C740
Voluntary wheel running increases satellite cell abundance and improves recovery from disuse in gastrocnemius muscles from mice.
Brooks MJ, Hajira A, Mohamed JS, Alway SE
Journal of applied physiology (Bethesda, Md. : 1985) 2018 Jun 1;124(6):1616-1628
Journal of applied physiology (Bethesda, Md. : 1985) 2018 Jun 1;124(6):1616-1628
Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice.
Gray NE, Zweig JA, Caruso M, Martin MD, Zhu JY, Quinn JF, Soumyanath A
Brain and behavior 2018 Jul;8(7):e01024
Brain and behavior 2018 Jul;8(7):e01024
MicroRNA-208a Correlates Apoptosis and Oxidative Stress Induced by H(2)O(2) through Protein Tyrosine Kinase/Phosphatase Balance in Cardiomyocytes.
Liu A, Sun Y, Yu B
International heart journal 2018 Jul 31;59(4):829-836
International heart journal 2018 Jul 31;59(4):829-836
A brain-enriched Drp1 isoform associates with lysosomes, late endosomes, and the plasma membrane.
Itoh K, Adachi Y, Yamada T, Suzuki TL, Otomo T, McBride HM, Yoshimori T, Iijima M, Sesaki H
The Journal of biological chemistry 2018 Jul 27;293(30):11809-11822
The Journal of biological chemistry 2018 Jul 27;293(30):11809-11822
Postnatal Development and Distribution of Sympathetic Innervation in Mouse Skeletal Muscle.
Straka T, Vita V, Prokshi K, Hörner SJ, Khan MM, Pirazzini M, Williams MPI, Hafner M, Zaglia T, Rudolf R
International journal of molecular sciences 2018 Jul 1;19(7)
International journal of molecular sciences 2018 Jul 1;19(7)
Effect and molecular mechanism of mTOR inhibitor rapamycin on temozolomide-induced autophagic death of U251 glioma cells.
Li B, Zhou C, Yi L, Xu L, Xu M
Oncology letters 2018 Feb;15(2):2477-2484
Oncology letters 2018 Feb;15(2):2477-2484
EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells.
Mimche PN, Lee CM, Mimche SM, Thapa M, Grakoui A, Henkemeyer M, Lamb TJ
Scientific reports 2018 Feb 7;8(1):2532
Scientific reports 2018 Feb 7;8(1):2532
Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.
Ryan T, Bamm VV, Stykel MG, Coackley CL, Humphries KM, Jamieson-Williams R, Ambasudhan R, Mosser DD, Lipton SA, Harauz G, Ryan SD
Nature communications 2018 Feb 26;9(1):817
Nature communications 2018 Feb 26;9(1):817
Estradiol signaling mediates gender difference in visceral adiposity via autophagy.
Tao Z, Zheng LD, Smith C, Luo J, Robinson A, Almeida FA, Wang Z, Olumi AF, Liu D, Cheng Z
Cell death & disease 2018 Feb 22;9(3):309
Cell death & disease 2018 Feb 22;9(3):309
Long noncoding RNA MALAT1 suppresses breast cancer metastasis.
Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L
Nature genetics 2018 Dec;50(12):1705-1715
Nature genetics 2018 Dec;50(12):1705-1715
Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines.
Liu J, Ma'ayeh S, Peirasmaki D, Lundström-Stadelmann B, Hellman L, Svärd SG
Virulence 2018 Dec 31;9(1):879-894
Virulence 2018 Dec 31;9(1):879-894
Functional Assessment of Patient-Derived Retinal Pigment Epithelial Cells Edited by CRISPR/Cas9.
Foltz LP, Howden SE, Thomson JA, Clegg DO
International journal of molecular sciences 2018 Dec 19;19(12)
International journal of molecular sciences 2018 Dec 19;19(12)
Anti-neuropilin-1 monoclonal antibody suppresses the migration and invasion of human gastric cancer cells via Akt dephosphorylation.
Ding Y, Zhou J, Wang S, Li Y, Mi Y, Gao S, Xu Y, Chen Y, Yan J
Experimental and therapeutic medicine 2018 Aug;16(2):537-546
Experimental and therapeutic medicine 2018 Aug;16(2):537-546
A kindred with mutant IKAROS and autoimmunity.
Van Nieuwenhove E, Garcia-Perez JE, Helsen C, Rodriguez PD, van Schouwenburg PA, Dooley J, Schlenner S, van der Burg M, Verhoeyen E, Gijsbers R, Frietze S, Schjerven H, Meyts I, Claessens F, Humblet-Baron S, Wouters C, Liston A
The Journal of allergy and clinical immunology 2018 Aug;142(2):699-702.e12
The Journal of allergy and clinical immunology 2018 Aug;142(2):699-702.e12
Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa.
Li L, Jiao X, D'Atri I, Ono F, Nelson R, Chan CC, Nakaya N, Ma Z, Ma Y, Cai X, Zhang L, Lin S, Hameed A, Chioza BA, Hardy H, Arno G, Hull S, Khan MI, Fasham J, Harlalka GV, Michaelides M, Moore AT, Coban Akdemir ZH, Jhangiani S, Lupski JR, Cremers FPM, Qamar R, Salman A, Chilton J, Self J, Ayyagari R, Kabir F, Naeem MA, Ali M, Akram J, Sieving PA, Riazuddin S, Baple EL, Riazuddin SA, Crosby AH, Hejtmancik JF
PLoS genetics 2018 Aug;14(8):e1007504
PLoS genetics 2018 Aug;14(8):e1007504
Core circadian clock gene expression in human dental pulp-derived cells in response to L-mimosine, hypoxia and echinomycin.
Janjić K, Kurzmann C, Moritz A, Agis H
European journal of oral sciences 2018 Aug;126(4):263-271
European journal of oral sciences 2018 Aug;126(4):263-271
Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo.
Thakur S, Daley B, Gaskins K, Vasko VV, Boufraqech M, Patel D, Sourbier C, Reece J, Cheng SY, Kebebew E, Agarwal S, Klubo-Gwiezdzinska J
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Aug 15;24(16):4030-4043
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Aug 15;24(16):4030-4043
Bromodomain-containing protein 4-independent transcriptional activation by autoimmune regulator (AIRE) and NF-κB.
Huang F, Shao W, Fujinaga K, Peterlin BM
The Journal of biological chemistry 2018 Apr 6;293(14):4993-5004
The Journal of biological chemistry 2018 Apr 6;293(14):4993-5004
Sex Specific Alterations in α4*Nicotinic Receptor Expression in the Nucleus Accumbens.
Holgate JY, Tarren JR, Bartlett SE
Brain sciences 2018 Apr 19;8(4)
Brain sciences 2018 Apr 19;8(4)
Fusogenic micropeptide Myomixer is essential for satellite cell fusion and muscle regeneration.
Bi P, McAnally JR, Shelton JM, Sánchez-Ortiz E, Bassel-Duby R, Olson EN
Proceedings of the National Academy of Sciences of the United States of America 2018 Apr 10;115(15):3864-3869
Proceedings of the National Academy of Sciences of the United States of America 2018 Apr 10;115(15):3864-3869
Postnatal tendon growth and remodeling require platelet-derived growth factor receptor signaling.
Sugg KB, Markworth JF, Disser NP, Rizzi AM, Talarek JR, Sarver DC, Brooks SV, Mendias CL
American journal of physiology. Cell physiology 2018 Apr 1;314(4):C389-C403
American journal of physiology. Cell physiology 2018 Apr 1;314(4):C389-C403
E2F6 Impairs Glycolysis and Activates BDH1 Expression Prior to Dilated Cardiomyopathy.
Major JL, Dewan A, Salih M, Leddy JJ, Tuana BS
PloS one 2017;12(1):e0170066
PloS one 2017;12(1):e0170066
Diamond, graphite, and graphene oxide nanoparticles decrease migration and invasiveness in glioblastoma cell lines by impairing extracellular adhesion.
Wierzbicki M, Jaworski S, Kutwin M, Grodzik M, Strojny B, Kurantowicz N, Zdunek K, Chodun R, Chwalibog A, Sawosz E
International journal of nanomedicine 2017;12:7241-7254
International journal of nanomedicine 2017;12:7241-7254
Progerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes.
Hilton BA, Liu J, Cartwright BM, Liu Y, Breitman M, Wang Y, Jones R, Tang H, Rusinol A, Musich PR, Zou Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Sep;31(9):3882-3893
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Sep;31(9):3882-3893
Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles.
de Castro Martin IF, Fournier G, Sachse M, Pizarro-Cerda J, Risco C, Naffakh N
Nature communications 2017 Nov 9;8(1):1396
Nature communications 2017 Nov 9;8(1):1396
Neuroprotective effect of Ruminococcus albus on oxidatively stressed SH-SY5Y cells and animals.
Park J, Lee J, Yeom Z, Heo D, Lim YH
Scientific reports 2017 Nov 6;7(1):14520
Scientific reports 2017 Nov 6;7(1):14520
Expression and Subcellular Localization of the Kaposi's Sarcoma-Associated Herpesvirus K15P Protein during Latency and Lytic Reactivation in Primary Effusion Lymphoma Cells.
Smith CG, Kharkwal H, Wilson DW
Journal of virology 2017 Nov 1;91(21)
Journal of virology 2017 Nov 1;91(21)
Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains.
AlAmri MA, Kadri H, Alderwick LJ, Simpkins NS, Mehellou Y
ChemMedChem 2017 May 9;12(9):639-645
ChemMedChem 2017 May 9;12(9):639-645
Nimodipine but Not Nifedipine Promotes Expression of Fatty Acid 2-Hydroxylase in a Surgical Stress Model Based on Neuro2a Cells.
Herzfeld E, Speh L, Strauss C, Scheller C
International journal of molecular sciences 2017 May 3;18(5)
International journal of molecular sciences 2017 May 3;18(5)
Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis.
Ejarque M, Ceperuelo-Mallafré V, Serena C, Pachón G, Núñez-Álvarez Y, Terrón-Puig M, Calvo E, Núñez-Roa C, Oliva-Olivera W, Tinahones FJ, Peinado MA, Vendrell J, Fernández-Veledo S
Cell death & disease 2017 May 18;8(5):e2802
Cell death & disease 2017 May 18;8(5):e2802
Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis.
Whitson JA, Zhang X, Medvedovic M, Chen J, Wei Z, Monnier VM, Fan X
Investigative ophthalmology & visual science 2017 May 1;58(5):2666-2684
Investigative ophthalmology & visual science 2017 May 1;58(5):2666-2684
Annexin A6 controls neuronal membrane dynamics throughout chick cranial sensory gangliogenesis.
Shah A, Schiffmacher AT, Taneyhill LA
Developmental biology 2017 May 1;425(1):85-99
Developmental biology 2017 May 1;425(1):85-99
Elevating expression of MeCP2 T158M rescues DNA binding and Rett syndrome-like phenotypes.
Lamonica JM, Kwon DY, Goffin D, Fenik P, Johnson BS, Cui Y, Guo H, Veasey S, Zhou Z
The Journal of clinical investigation 2017 May 1;127(5):1889-1904
The Journal of clinical investigation 2017 May 1;127(5):1889-1904
The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts: Implications for the Use of Autologous Blood Products for Muscle Regeneration.
Miroshnychenko O, Chang WT, Dragoo JL
The American journal of sports medicine 2017 Mar;45(4):945-953
The American journal of sports medicine 2017 Mar;45(4):945-953
Protective Effect of Met12, a Small Peptide Inhibitor of Fas, on the Retinal Pigment Epithelium and Photoreceptor After Sodium Iodate Injury.
Xiao J, Yao J, Jia L, Lin C, Zacks DN
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1801-1810
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1801-1810
Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain.
Lei W, Mullen N, McCarthy S, Brann C, Richard P, Cormier J, Edwards K, Bilsky EJ, Streicher JM
The Journal of biological chemistry 2017 Jun 23;292(25):10414-10428
The Journal of biological chemistry 2017 Jun 23;292(25):10414-10428
HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.
Li Z, Zhou L, Prodromou C, Savic V, Pearl LH
Cell reports 2017 Jun 20;19(12):2515-2528
Cell reports 2017 Jun 20;19(12):2515-2528
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
Sociali G, Magnone M, Ravera S, Damonte P, Vigliarolo T, Von Holtey M, Vellone VG, Millo E, Caffa I, Cea M, Parenti MD, Del Rio A, Murone M, Mostoslavsky R, Grozio A, Nencioni A, Bruzzone S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Jul;31(7):3138-3149
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Jul;31(7):3138-3149
RASSF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P(2).
Chen YJ, Chang CL, Lee WR, Liou J
The Journal of cell biology 2017 Jul 3;216(7):2011-2025
The Journal of cell biology 2017 Jul 3;216(7):2011-2025
A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity.
Suresh SN, Chavalmane AK, Dj V, Yarreiphang H, Rai S, Paul A, Clement JP, Alladi PA, Manjithaya R
Autophagy 2017 Jul 3;13(7):1221-1234
Autophagy 2017 Jul 3;13(7):1221-1234
Conditioned medium from LS 174T goblet cells treated with oxyresveratrol strengthens tight junctions in Caco-2 cells.
Hwang D, Jo H, Hwang S, Kim JK, Kim IH, Lim YH
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jan;85:280-286
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jan;85:280-286
Interactions between the Coxiella burnetii parasitophorous vacuole and the endoplasmic reticulum involve the host protein ORP1L.
Justis AV, Hansen B, Beare PA, King KB, Heinzen RA, Gilk SD
Cellular microbiology 2017 Jan;19(1)
Cellular microbiology 2017 Jan;19(1)
Expression of Cav1.3 calcium channel in the human and mouse colon: posttranscriptional inhibition by IFNγ.
Radhakrishnan VM, Gilpatrick MM, Parsa NA, Kiela PR, Ghishan FK
American journal of physiology. Gastrointestinal and liver physiology 2017 Jan 1;312(1):G77-G84
American journal of physiology. Gastrointestinal and liver physiology 2017 Jan 1;312(1):G77-G84
Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system.
Tyburski AL, Cheng L, Assari S, Darvish K, Elliott MB
The journal of headache and pain 2017 Dec;18(1):16
The journal of headache and pain 2017 Dec;18(1):16
GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury.
Chung HK, Kim JT, Kim HW, Kwon M, Kim SY, Shong M, Kim KS, Yi HS
Scientific reports 2017 Dec 8;7(1):17238
Scientific reports 2017 Dec 8;7(1):17238
REST regulates the cell cycle for cardiac development and regeneration.
Zhang D, Wang Y, Lu P, Wang P, Yuan X, Yan J, Cai C, Chang CP, Zheng D, Wu B, Zhou B
Nature communications 2017 Dec 7;8(1):1979
Nature communications 2017 Dec 7;8(1):1979
RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.
Chang EY, Novoa CA, Aristizabal MJ, Coulombe Y, Segovia R, Chaturvedi R, Shen Y, Keong C, Tam AS, Jones SJM, Masson JY, Kobor MS, Stirling PC
The Journal of cell biology 2017 Dec 4;216(12):3991-4005
The Journal of cell biology 2017 Dec 4;216(12):3991-4005
A module for Rac temporal signal integration revealed with optogenetics.
Graziano BR, Gong D, Anderson KE, Pipathsouk A, Goldberg AR, Weiner OD
The Journal of cell biology 2017 Aug 7;216(8):2515-2531
The Journal of cell biology 2017 Aug 7;216(8):2515-2531
Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice.
Tang S, Wang IJ, Yue C, Takano H, Terzic B, Pance K, Lee JY, Cui Y, Coulter DA, Zhou Z
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Aug 2;37(31):7420-7437
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Aug 2;37(31):7420-7437
Small-size recombinant adenoviral hexon protein fragments for the production of virus-type specific antibodies.
Pacesa M, Hendrickx R, Bieri M, Flatt JW, Greber UF, Hemmi S
Virology journal 2017 Aug 18;14(1):158
Virology journal 2017 Aug 18;14(1):158
Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.
Zhang D, Wu B, Wang P, Wang Y, Lu P, Nechiporuk T, Floss T, Greally JM, Zheng D, Zhou B
Nucleic acids research 2017 Apr 7;45(6):3102-3115
Nucleic acids research 2017 Apr 7;45(6):3102-3115
The c-Jun N-terminal kinase prevents oxidative stress induced by UV and thermal stresses in corals and human cells.
Courtial L, Picco V, Grover R, Cormerais Y, Rottier C, Labbe A, Pagès G, Ferrier-Pagès C
Scientific reports 2017 Apr 4;7:45713
Scientific reports 2017 Apr 4;7:45713
Control of muscle formation by the fusogenic micropeptide myomixer.
Bi P, Ramirez-Martinez A, Li H, Cannavino J, McAnally JR, Shelton JM, Sánchez-Ortiz E, Bassel-Duby R, Olson EN
Science (New York, N.Y.) 2017 Apr 21;356(6335):323-327
Science (New York, N.Y.) 2017 Apr 21;356(6335):323-327
Plasmodium parasite as an effective hepatocellular carcinoma antigen glypican-3 delivery vector.
Liu Q, Yang Y, Tan X, Tao Z, Adah D, Yu S, Lu J, Zhao S, Qin L, Qin L, Chen X
Oncotarget 2017 Apr 11;8(15):24785-24796
Oncotarget 2017 Apr 11;8(15):24785-24796
Mitochondrial connexin40 regulates mitochondrial calcium uptake in coronary endothelial cells.
Guo R, Si R, Scott BT, Makino A
American journal of physiology. Cell physiology 2017 Apr 1;312(4):C398-C406
American journal of physiology. Cell physiology 2017 Apr 1;312(4):C398-C406
Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells.
Patzlaff NE, Nemec KM, Malone SG, Li Y, Zhao X
Human molecular genetics 2017 Apr 1;26(7):1340-1352
Human molecular genetics 2017 Apr 1;26(7):1340-1352
Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment.
Zou P, Liu L, Zheng LD, Payne KK, Manjili MH, Idowu MO, Zhang J, Schmelz EM, Cheng Z
Oxidative medicine and cellular longevity 2016;2016:4085727
Oxidative medicine and cellular longevity 2016;2016:4085727
FoxO1 interacts with transcription factor EB and differentially regulates mitochondrial uncoupling proteins via autophagy in adipocytes.
Liu L, Tao Z, Zheng LD, Brooke JP, Smith CM, Liu D, Long YC, Cheng Z
Cell death discovery 2016;2:16066
Cell death discovery 2016;2:16066
Sensitive and Quantitative Three-Color Protein Imaging in Fission Yeast Using Spectrally Diverse, Recoded Fluorescent Proteins with Experimentally-Characterized In Vivo Maturation Kinetics.
Al-Sady B, Greenstein RA, El-Samad HJ, Braun S, Madhani HD
PloS one 2016;11(8):e0159292
PloS one 2016;11(8):e0159292
Influence of Matrices on 3D-Cultured Prostate Cancer Cells' Drug Response and Expression of Drug-Action Associated Proteins.
Edmondson R, Adcock AF, Yang L
PloS one 2016;11(6):e0158116
PloS one 2016;11(6):e0158116
Targeted Expression of Catalase to Mitochondria Protects Against Ischemic Myopathy in High-Fat Diet-Fed Mice.
Ryan TE, Schmidt CA, Green TD, Spangenburg EE, Neufer PD, McClung JM
Diabetes 2016 Sep;65(9):2553-68
Diabetes 2016 Sep;65(9):2553-68
Concomitant beige adipocyte differentiation upon induction of mesenchymal stem cells into brown adipocytes.
Wang YL, Lin SP, Hsieh PC, Hung SC
Biochemical and biophysical research communications 2016 Sep 16;478(2):689-95
Biochemical and biophysical research communications 2016 Sep 16;478(2):689-95
Protein-Protein Interactions Suggest Novel Activities of Human Cytomegalovirus Tegument Protein pUL103.
Ortiz DA, Glassbrook JE, Pellett PE
Journal of virology 2016 Sep 1;90(17):7798-810
Journal of virology 2016 Sep 1;90(17):7798-810
Brief Communication: SIR-2.1-dependent lifespan extension of Caenorhabditis elegans by oxyresveratrol and resveratrol.
Lee J, Kwon G, Park J, Kim JK, Lim YH
Experimental biology and medicine (Maywood, N.J.) 2016 Oct;241(16):1757-63
Experimental biology and medicine (Maywood, N.J.) 2016 Oct;241(16):1757-63
Zinc finger protein 407 overexpression upregulates PPAR target gene expression and improves glucose homeostasis in mice.
Charrier A, Wang L, Stephenson EJ, Ghanta SV, Ko CW, Croniger CM, Bridges D, Buchner DA
American journal of physiology. Endocrinology and metabolism 2016 Nov 1;311(5):E869-E880
American journal of physiology. Endocrinology and metabolism 2016 Nov 1;311(5):E869-E880
The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation.
Tran NT, Su H, Khodadadi-Jamayran A, Lin S, Zhang L, Zhou D, Pawlik KM, Townes TM, Chen Y, Mulloy JC, Zhao X
EMBO reports 2016 Jun;17(6):887-900
EMBO reports 2016 Jun;17(6):887-900
SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.
Raducu M, Fung E, Serres S, Infante P, Barberis A, Fischer R, Bristow C, Thézénas ML, Finta C, Christianson JC, Buffa FM, Kessler BM, Sibson NR, Di Marcotullio L, Toftgård R, D'Angiolella V
The EMBO journal 2016 Jul 1;35(13):1400-16
The EMBO journal 2016 Jul 1;35(13):1400-16
Exercise training reverses myocardial dysfunction induced by CaMKIIδC overexpression by restoring Ca2+ homeostasis.
Høydal MA, Stølen TO, Kettlewell S, Maier LS, Brown JH, Sowa T, Catalucci D, Condorelli G, Kemi OJ, Smith GL, Wisløff U
Journal of applied physiology (Bethesda, Md. : 1985) 2016 Jul 1;121(1):212-20
Journal of applied physiology (Bethesda, Md. : 1985) 2016 Jul 1;121(1):212-20
Vesicular Galectin-3 levels decrease with donor age and contribute to the reduced osteo-inductive potential of human plasma derived extracellular vesicles.
Weilner S, Keider V, Winter M, Harreither E, Salzer B, Weiss F, Schraml E, Messner P, Pietschmann P, Hildner F, Gabriel C, Redl H, Grillari-Voglauer R, Grillari J
Aging 2016 Jan;8(1):16-33
Aging 2016 Jan;8(1):16-33
miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer.
Tan X, Fu Y, Chen L, Lee W, Lai Y, Rezaei K, Tabbara S, Latham P, Teal CB, Man YG, Siegel RS, Brem RF, Fu SW
Oncotarget 2016 Jan 5;7(1):293-307
Oncotarget 2016 Jan 5;7(1):293-307
The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.
Ghanem LR, Kromer A, Silverman IM, Chatterji P, Traxler E, Penzo-Mendez A, Weiss MJ, Stanger BZ, Liebhaber SA
Molecular and cellular biology 2016 Jan 15;36(2):304-19
Molecular and cellular biology 2016 Jan 15;36(2):304-19
Registered report: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.
Haven B, Heilig E, Donham C, Settles M, Vasilevsky N, Owen K, Reproducibility Project: Cancer Biology, Reproducibility Project Cancer Biology
eLife 2016 Feb 23;5
eLife 2016 Feb 23;5
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Li Y, Banerjee S, Wang Y, Goldstein SA, Dong B, Gaughan C, Silverman RH, Weiss SR
Proceedings of the National Academy of Sciences of the United States of America 2016 Feb 23;113(8):2241-6
Proceedings of the National Academy of Sciences of the United States of America 2016 Feb 23;113(8):2241-6
Progress of endocytic CHRN to autophagic degradation is regulated by RAB5-GTPase and T145 phosphorylation of SH3GLB1 at mouse neuromuscular junctions in vivo.
Wild F, Khan MM, Straka T, Rudolf R
Autophagy 2016 Dec;12(12):2300-2310
Autophagy 2016 Dec;12(12):2300-2310
Stiffness of pancreatic cancer cells is associated with increased invasive potential.
Nguyen AV, Nyberg KD, Scott MB, Welsh AM, Nguyen AH, Wu N, Hohlbauch SV, Geisse NA, Gibb EA, Robertson AG, Donahue TR, Rowat AC
Integrative biology : quantitative biosciences from nano to macro 2016 Dec 5;8(12):1232-1245
Integrative biology : quantitative biosciences from nano to macro 2016 Dec 5;8(12):1232-1245
Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling.
Kim TH, Gill NK, Nyberg KD, Nguyen AV, Hohlbauch SV, Geisse NA, Nowell CJ, Sloan EK, Rowat AC
Journal of cell science 2016 Dec 15;129(24):4563-4575
Journal of cell science 2016 Dec 15;129(24):4563-4575
FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes.
Liu L, Zheng LD, Zou P, Brooke J, Smith C, Long YC, Almeida FA, Liu D, Cheng Z
Cell cycle (Georgetown, Tex.) 2016 Aug 2;15(15):2033-41
Cell cycle (Georgetown, Tex.) 2016 Aug 2;15(15):2033-41
Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia.
Ding L, Hayes MM, Photenhauer A, Eaton KA, Li Q, Ocadiz-Ruiz R, Merchant JL
The Journal of clinical investigation 2016 Aug 1;126(8):2867-80
The Journal of clinical investigation 2016 Aug 1;126(8):2867-80
Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma.
Nguyen J, Bernert R, In K, Kang P, Sebastiao N, Hu C, Hastings KT
Melanoma research 2016 Apr;26(2):125-37
Melanoma research 2016 Apr;26(2):125-37
Pseudouridine in mRNA: Incorporation, Detection, and Recoding.
Wu G, Huang C, Yu YT
Methods in enzymology 2015;560:187-217
Methods in enzymology 2015;560:187-217
The novel function of JADE1S in cytokinesis of epithelial cells.
Siriwardana NS, Meyer RD, Panchenko MV
Cell cycle (Georgetown, Tex.) 2015;14(17):2821-34
Cell cycle (Georgetown, Tex.) 2015;14(17):2821-34
Tunable and reversible drug control of protein production via a self-excising degron.
Chung HK, Jacobs CL, Huo Y, Yang J, Krumm SA, Plemper RK, Tsien RY, Lin MZ
Nature chemical biology 2015 Sep;11(9):713-20
Nature chemical biology 2015 Sep;11(9):713-20
Quantitative Proteomic Verification of Membrane Proteins as Potential Therapeutic Targets Located in the 11q13 Amplicon in Cancers.
Hoover H, Li J, Marchese J, Rothwell C, Borawoski J, Jeffery DA, Gaither LA, Finkel N
Journal of proteome research 2015 Sep 4;14(9):3670-9
Journal of proteome research 2015 Sep 4;14(9):3670-9
Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy.
Li F, Buck D, De Winter J, Kolb J, Meng H, Birch C, Slater R, Escobar YN, Smith JE 3rd, Yang L, Konhilas J, Lawlor MW, Ottenheijm C, Granzier HL
Human molecular genetics 2015 Sep 15;24(18):5219-33
Human molecular genetics 2015 Sep 15;24(18):5219-33
Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.
Volta M, Cataldi S, Beccano-Kelly D, Munsie L, Tatarnikov I, Chou P, Bergeron S, Mitchell E, Lim R, Khinda J, Lloret A, Bennett CF, Paradiso C, Morari M, Farrer MJ, Milnerwood AJ
Parkinsonism & related disorders 2015 Oct;21(10):1156-63
Parkinsonism & related disorders 2015 Oct;21(10):1156-63
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.
Zhang L, Tran NT, Su H, Wang R, Lu Y, Tang H, Aoyagi S, Guo A, Khodadadi-Jamayran A, Zhou D, Qian K, Hricik T, Côté J, Han X, Zhou W, Laha S, Abdel-Wahab O, Levine RL, Raffel G, Liu Y, Chen D, Li H, Townes T, Wang H, Deng H, Zheng YG, Leslie C, Luo M, Zhao X
eLife 2015 Nov 17;4
eLife 2015 Nov 17;4
The amino-terminal tails of histones H2A and H3 coordinate efficient base excision repair, DNA damage signaling and postreplication repair in Saccharomyces cerevisiae.
Meas R, Smerdon MJ, Wyrick JJ
Nucleic acids research 2015 May 26;43(10):4990-5001
Nucleic acids research 2015 May 26;43(10):4990-5001
A small molecule activator of AKT does not reduce ischemic injury of the rat heart.
Moreira JB, Wohlwend M, Alves MN, Wisløff U, Bye A
Journal of translational medicine 2015 Mar 1;13:76
Journal of translational medicine 2015 Mar 1;13:76
Histone Sprocket Arginine Residues Are Important for Gene Expression, DNA Repair, and Cell Viability in Saccharomyces cerevisiae.
Hodges AJ, Gallegos IJ, Laughery MF, Meas R, Tran L, Wyrick JJ
Genetics 2015 Jul;200(3):795-806
Genetics 2015 Jul;200(3):795-806
Legionella suppresses the host unfolded protein response via multiple mechanisms.
Treacy-Abarca S, Mukherjee S
Nature communications 2015 Jul 29;6:7887
Nature communications 2015 Jul 29;6:7887
Inhibition of notch signalling ameliorates experimental inflammatory arthritis.
Park JS, Kim SH, Kim K, Jin CH, Choi KY, Jang J, Choi Y, Gwon AR, Baik SH, Yun UJ, Chae SY, Lee S, Kang YM, Lee KC, Arumugam TV, Mattson MP, Park JH, Jo DG
Annals of the rheumatic diseases 2015 Jan;74(1):267-74
Annals of the rheumatic diseases 2015 Jan;74(1):267-74
Tamoxifen reduces fat mass by boosting reactive oxygen species.
Liu L, Zou P, Zheng L, Linarelli LE, Amarell S, Passaro A, Liu D, Cheng Z
Cell death & disease 2015 Jan 8;6(1):e1586
Cell death & disease 2015 Jan 8;6(1):e1586
Development of organometallic S6K1 inhibitors.
Qin J, Rajaratnam R, Feng L, Salami J, Barber-Rotenberg JS, Domsic J, Reyes-Uribe P, Liu H, Dang W, Berger SL, Villanueva J, Meggers E, Marmorstein R
Journal of medicinal chemistry 2015 Jan 8;58(1):305-14
Journal of medicinal chemistry 2015 Jan 8;58(1):305-14
Biocontainment of genetically modified organisms by synthetic protein design.
Mandell DJ, Lajoie MJ, Mee MT, Takeuchi R, Kuznetsov G, Norville JE, Gregg CJ, Stoddard BL, Church GM
Nature 2015 Feb 5;518(7537):55-60
Nature 2015 Feb 5;518(7537):55-60
Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression.
Rolyan H, Tyurina YY, Hernandez M, Amoscato AA, Sparvero LJ, Nmezi BC, Lu Y, Estécio MR, Lin K, Chen J, He RR, Gong P, Rigatti LH, Dupree J, Bayır H, Kagan VE, Casaccia P, Padiath QS
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Aug 26;35(34):12002-17
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Aug 26;35(34):12002-17
Experimental colitis is associated with transcriptional inhibition of Na+/Ca2+ exchanger isoform 1 (NCX1) expression by interferon γ in the renal distal convoluted tubules.
Radhakrishnan VM, Kojs P, Ramalingam R, Midura-Kiela MT, Angeli P, Kiela PR, Ghishan FK
The Journal of biological chemistry 2015 Apr 3;290(14):8964-74
The Journal of biological chemistry 2015 Apr 3;290(14):8964-74
ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment.
Surma M, Handy C, Chang J, Kapur R, Wei L, Shi J
PloS one 2014;9(3):e90758
PloS one 2014;9(3):e90758
Genome-wide screening identified that miR-134 acts as a metastasis suppressor by targeting integrin β1 in hepatocellular carcinoma.
Zha R, Guo W, Zhang Z, Qiu Z, Wang Q, Ding J, Huang S, Chen T, Gu J, Yao M, He X
PloS one 2014;9(2):e87665
PloS one 2014;9(2):e87665
Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging.
Walker MD, Volta M, Cataldi S, Dinelle K, Beccano-Kelly D, Munsie L, Kornelsen R, Mah C, Chou P, Co K, Khinda J, Mroczek M, Bergeron S, Yu K, Cao LP, Funk N, Ott T, Galter D, Riess O, Biskup S, Milnerwood AJ, Stoessl AJ, Farrer MJ, Sossi V
Journal of Parkinson's disease 2014;4(3):483-98
Journal of Parkinson's disease 2014;4(3):483-98
ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.
Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M, Chen D, Sun Y, Woodward WA, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC, Chen J, Ma L
Nature cell biology 2014 Sep;16(9):864-75
Nature cell biology 2014 Sep;16(9):864-75
miR-638 mediated regulation of BRCA1 affects DNA repair and sensitivity to UV and cisplatin in triple-negative breast cancer.
Tan X, Peng J, Fu Y, An S, Rezaei K, Tabbara S, Teal CB, Man YG, Brem RF, Fu SW
Breast cancer research : BCR 2014 Sep 17;16(5):435
Breast cancer research : BCR 2014 Sep 17;16(5):435
Expression of matriptase correlates with tumour progression and clinical prognosis in oral squamous cell carcinoma.
Cheng MF, Huang MS, Lin CS, Lin LH, Lee HS, Jiang JC, Hsia KT
Histopathology 2014 Jul;65(1):24-34
Histopathology 2014 Jul;65(1):24-34
miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13.
Zhang P, Wang L, Rodriguez-Aguayo C, Yuan Y, Debeb BG, Chen D, Sun Y, You MJ, Liu Y, Dean DC, Woodward WA, Liang H, Yang X, Lopez-Berestein G, Sood AK, Hu Y, Ang KK, Chen J, Ma L
Nature communications 2014 Dec 5;5:5671
Nature communications 2014 Dec 5;5:5671
Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.
Freund A, Zhong FL, Venteicher AS, Meng Z, Veenstra TD, Frydman J, Artandi SE
Cell 2014 Dec 4;159(6):1389-403
Cell 2014 Dec 4;159(6):1389-403
Identification of human cytomegalovirus genes important for biogenesis of the cytoplasmic virion assembly complex.
Das S, Ortiz DA, Gurczynski SJ, Khan F, Pellett PE
Journal of virology 2014 Aug;88(16):9086-99
Journal of virology 2014 Aug;88(16):9086-99
The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes.
Huether R, Dong L, Chen X, Wu G, Parker M, Wei L, Ma J, Edmonson MN, Hedlund EK, Rusch MC, Shurtleff SA, Mulder HL, Boggs K, Vadordaria B, Cheng J, Yergeau D, Song G, Becksfort J, Lemmon G, Weber C, Cai Z, Dang J, Walsh M, Gedman AL, Faber Z, Easton J, Gruber T, Kriwacki RW, Partridge JF, Ding L, Wilson RK, Mardis ER, Mullighan CG, Gilbertson RJ, Baker SJ, Zambetti G, Ellison DW, Zhang J, Downing JR
Nature communications 2014 Apr 8;5:3630
Nature communications 2014 Apr 8;5:3630
Sensitization of mesothelioma cells to platinum-based chemotherapy by GSTπ knockdown.
Chen J, Solomides C, Simpkins H
Biochemical and biophysical research communications 2014 Apr 25;447(1):77-82
Biochemical and biophysical research communications 2014 Apr 25;447(1):77-82
Growth and differentiation factor 3 induces expression of genes related to differentiation in a model of cancer stem cells and protects them from retinoic acid-induced apoptosis.
Tykwinska K, Lauster R, Knaus P, Rosowski M
PloS one 2013;8(8):e70612
PloS one 2013;8(8):e70612
Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts.
Pritchard TJ, Kawase Y, Haghighi K, Anjak A, Cai W, Jiang M, Nicolaou P, Pylar G, Karakikes I, Rapti K, Rubinstein J, Hajjar RJ, Kranias EG
PloS one 2013;8(12):e80717
PloS one 2013;8(12):e80717
Role of deregulated microRNAs in breast cancer progression using FFPE tissue.
Chen L, Li Y, Fu Y, Peng J, Mo MH, Stamatakos M, Teal CB, Brem RF, Stojadinovic A, Grinkemeyer M, McCaffrey TA, Man YG, Fu SW
PloS one 2013;8(1):e54213
PloS one 2013;8(1):e54213
Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.
Shim JH, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA, Zaller D, Zhai B, Gygi S, Glimcher LH, Jones DC
The Journal of clinical investigation 2013 Sep;123(9):4010-22
The Journal of clinical investigation 2013 Sep;123(9):4010-22
Effect of beta-carotene on oxidative stress and expression of cardiac connexin 43.
Novo R, Azevedo PS, Minicucci MF, Zornoff LA, Paiva SA
Arquivos brasileiros de cardiologia 2013 Sep;101(3):233-9
Arquivos brasileiros de cardiologia 2013 Sep;101(3):233-9
Local injection of lentivirus encoding LINGO-1-shRNA promotes functional recovery in rats with complete spinal cord transection.
Cen J, Wu H, Wang J, Ren X, Zhang H, Wang J, Wan Y, Deng Y
Spine 2013 Sep 1;38(19):1632-9
Spine 2013 Sep 1;38(19):1632-9
Follicle-stimulating hormone inhibits apoptosis in ovarian cancer cells by regulating the OCT4 stem cell signaling pathway.
Zhang Z, Zhu Y, Lai Y, Wu X, Feng Z, Yu Y, Bast RC Jr, Wan X, Xi X, Feng Y
International journal of oncology 2013 Oct;43(4):1194-204
International journal of oncology 2013 Oct;43(4):1194-204
A small molecule multi-kinase inhibitor reduces influenza A virus replication by restricting viral RNA synthesis.
Martinez-Gil L, Alamares-Sapuay JG, Ramana Reddy MV, Goff PH, Premkumar Reddy E, Palese P
Antiviral research 2013 Oct;100(1):29-37
Antiviral research 2013 Oct;100(1):29-37
Epithelial-mesenchymal transition and tumor suppression are controlled by a reciprocal feedback loop between ZEB1 and Grainyhead-like-2.
Cieply B, Farris J, Denvir J, Ford HL, Frisch SM
Cancer research 2013 Oct 15;73(20):6299-309
Cancer research 2013 Oct 15;73(20):6299-309
Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein.
Singh VP, Rubinstein J, Arvanitis DA, Ren X, Gao X, Haghighi K, Gilbert M, Iyer VR, Kim DH, Cho C, Jones K, Lorenz JN, Armstrong CF, Wang HS, Gyorke S, Kranias EG
Journal of the American Heart Association 2013 Oct 14;2(5):e000460
Journal of the American Heart Association 2013 Oct 14;2(5):e000460
Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation.
Kimura R, Kasamatsu A, Koyama T, Fukumoto C, Kouzu Y, Higo M, Endo-Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K
BMC cancer 2013 Nov 21;13:555
BMC cancer 2013 Nov 21;13:555
Novel oleanolic vinyl boronates: synthesis and antitumor activity.
Moreira VM, Salvador JA, Simões S, Destro F, Gavioli R
European journal of medicinal chemistry 2013 May;63:46-56
European journal of medicinal chemistry 2013 May;63:46-56
Over-expression of the overexpressed in lung cancer 1 is associated with poor prognosis in epithelial ovarian cancer.
Jia C, Li X, Sun H, Sui L
Journal of surgical oncology 2013 Jun;107(8):847-52
Journal of surgical oncology 2013 Jun;107(8):847-52
c-di-GMP signaling regulates E. coli O157:H7 adhesion to colonic epithelium.
Hu J, Wang B, Fang X, Means WJ, McCormick RJ, Gomelsky M, Zhu MJ
Veterinary microbiology 2013 Jun 28;164(3-4):344-51
Veterinary microbiology 2013 Jun 28;164(3-4):344-51
Comparison of first dimension IPG and NEPHGE techniques in two-dimensional gel electrophoresis experiment with cytosolic unfolded protein response in Saccharomyces cerevisiae.
Slibinskas R, Ražanskas R, Zinkevičiūtė R, Čiplys E
Proteome science 2013 Jul 27;11(1):36
Proteome science 2013 Jul 27;11(1):36
Endothelial glucocorticoid receptor is required for protection against sepsis.
Goodwin JE, Feng Y, Velazquez H, Sessa WC
Proceedings of the National Academy of Sciences of the United States of America 2013 Jan 2;110(1):306-11
Proceedings of the National Academy of Sciences of the United States of America 2013 Jan 2;110(1):306-11
Involvement of endoplasmic reticulum stress in tauopathy.
Sakagami Y, Kudo T, Tanimukai H, Kanayama D, Omi T, Horiguchi K, Okochi M, Imaizumi K, Takeda M
Biochemical and biophysical research communications 2013 Jan 11;430(2):500-4
Biochemical and biophysical research communications 2013 Jan 11;430(2):500-4
The promotion of functional recovery and nerve regeneration after spinal cord injury by lentiviral vectors encoding Lingo-1 shRNA delivered by Pluronic F-127.
Wu HF, Cen JS, Zhong Q, Chen L, Wang J, Deng DY, Wan Y
Biomaterials 2013 Feb;34(6):1686-700
Biomaterials 2013 Feb;34(6):1686-700
Glucocorticoid receptor-beta up-regulation and steroid resistance induction by IL-17 and IL-23 cytokine stimulation in peripheral mononuclear cells.
Vazquez-Tello A, Halwani R, Hamid Q, Al-Muhsen S
Journal of clinical immunology 2013 Feb;33(2):466-78
Journal of clinical immunology 2013 Feb;33(2):466-78
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.
Chen L, Li Y, Lin CH, Chan TH, Chow RK, Song Y, Liu M, Yuan YF, Fu L, Kong KL, Qi L, Li Y, Zhang N, Tong AH, Kwong DL, Man K, Lo CM, Lok S, Tenen DG, Guan XY
Nature medicine 2013 Feb;19(2):209-16
Nature medicine 2013 Feb;19(2):209-16
A transient α-helical molecular recognition element in the disordered N-terminus of the Sgs1 helicase is critical for chromosome stability and binding of Top3/Rmi1.
Kennedy JA, Daughdrill GW, Schmidt KH
Nucleic acids research 2013 Dec;41(22):10215-27
Nucleic acids research 2013 Dec;41(22):10215-27
Deubiquitylation and stabilization of PTEN by USP13.
Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L
Nature cell biology 2013 Dec;15(12):1486-1494
Nature cell biology 2013 Dec;15(12):1486-1494
Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+ handling in ageing rabbit hearts.
Cooper LL, Li W, Lu Y, Centracchio J, Terentyeva R, Koren G, Terentyev D
The Journal of physiology 2013 Dec 1;591(23):5895-911
The Journal of physiology 2013 Dec 1;591(23):5895-911
Oleanolic acid and ursolic acid: novel hepatitis C virus antivirals that inhibit NS5B activity.
Kong L, Li S, Liao Q, Zhang Y, Sun R, Zhu X, Zhang Q, Wang J, Wu X, Fang X, Zhu Y
Antiviral research 2013 Apr;98(1):44-53
Antiviral research 2013 Apr;98(1):44-53
Histone deacetylase inhibitors induce epithelial-to-mesenchymal transition in prostate cancer cells.
Kong D, Ahmad A, Bao B, Li Y, Banerjee S, Sarkar FH
PloS one 2012;7(9):e45045
PloS one 2012;7(9):e45045
Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM.
Kong D, Heath E, Chen W, Cher ML, Powell I, Heilbrun L, Li Y, Ali S, Sethi S, Hassan O, Hwang C, Gupta N, Chitale D, Sakr WA, Menon M, Sarkar FH
PloS one 2012;7(3):e33729
PloS one 2012;7(3):e33729
Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease.
de Oliveira FL, Araújo-Jorge TC, de Souza EM, de Oliveira GM, Degrave WM, Feige JJ, Bailly S, Waghabi MC
PLoS neglected tropical diseases 2012;6(6):e1696
PLoS neglected tropical diseases 2012;6(6):e1696
Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment.
Kong D, Heath E, Chen W, Cher M, Powell I, Heilbrun L, Li Y, Ali S, Sethi S, Hassan O, Hwang C, Gupta N, Chitale D, Sakr WA, Menon M, Sarkar FH
American journal of translational research 2012;4(1):14-23
American journal of translational research 2012;4(1):14-23
Comparative effects of liensinine and neferine on the human ether-a-go-go-related gene potassium channel and pharmacological activity analysis.
Dong ZX, Zhao X, Gu DF, Shi YQ, Zhang J, Hu XX, Hu MQ, Yang BF, Li BX
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;29(3-4):431-42
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;29(3-4):431-42
Glucocorticoids augment survival and proliferation of tumor cells.
Gündisch S, Boeckeler E, Behrends U, Amtmann E, Ehrhardt H, Jeremias I
Anticancer research 2012 Oct;32(10):4251-61
Anticancer research 2012 Oct;32(10):4251-61
Hypothyroidism reduces ObRb-STAT3 leptin signalling in the hypothalamus and pituitary of rats associated with resistance to leptin acute anorectic action.
Calvino C, Souza LL, Costa-e-Sousa RH, Almeida NA, Trevenzoli IH, Pazos-Moura CC
The Journal of endocrinology 2012 Oct;215(1):129-35
The Journal of endocrinology 2012 Oct;215(1):129-35
Menthol inhibits the proliferation and motility of prostate cancer DU145 cells.
Wang Y, Wang X, Yang Z, Zhu G, Chen D, Meng Z
Pathology oncology research : POR 2012 Oct;18(4):903-10
Pathology oncology research : POR 2012 Oct;18(4):903-10
LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker.
Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC, Ma L
Nature medicine 2012 Oct;18(10):1511-7
Nature medicine 2012 Oct;18(10):1511-7
Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer.
Qiu ZX, Wang L, Han J, Liu D, Huang W, Altaf K, Qiu XS, Javed MA, Zheng J, Chen BJ, Li WM
Cancer science 2012 Oct;103(10):1774-9
Cancer science 2012 Oct;103(10):1774-9
The use of sigmoid pH gradients in free-flow isoelectric focusing of human endothelial cell proteins.
Ma X, Wildgruber R, Bauer J, Weber G, Infanger M, Grosse J, Grimm D
Electrophoresis 2012 May;33(9-10):1349-55
Electrophoresis 2012 May;33(9-10):1349-55
Side-stream smoking reduces intestinal inflammation and increases expression of tight junction proteins.
Wang H, Zhao JX, Hu N, Ren J, Du M, Zhu MJ
World journal of gastroenterology 2012 May 14;18(18):2180-7
World journal of gastroenterology 2012 May 14;18(18):2180-7
Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms.
Oh E, Kalwat MA, Kim MJ, Verhage M, Thurmond DC
The Journal of biological chemistry 2012 Jul 27;287(31):25821-33
The Journal of biological chemistry 2012 Jul 27;287(31):25821-33
AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity.
Yap TA, Walton MI, Grimshaw KM, Te Poele RH, Eve PD, Valenti MR, de Haven Brandon AK, Martins V, Zetterlund A, Heaton SP, Heinzmann K, Jones PS, Feltell RE, Reule M, Woodhead SJ, Davies TG, Lyons JF, Raynaud FI, Eccles SA, Workman P, Thompson NT, Garrett MD
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Jul 15;18(14):3912-23
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Jul 15;18(14):3912-23
In vitro and in vivo evaluations on osteogenesis and biodegradability of a β-tricalcium phosphate coated magnesium alloy.
Chai H, Guo L, Wang X, Gao X, Liu K, Fu Y, Guan J, Tan L, Yang K
Journal of biomedical materials research. Part A 2012 Feb;100(2):293-304
Journal of biomedical materials research. Part A 2012 Feb;100(2):293-304
Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids.
Grosse J, Wehland M, Pietsch J, Schulz H, Saar K, Hübner N, Eilles C, Bauer J, Abou-El-Ardat K, Baatout S, Ma X, Infanger M, Hemmersbach R, Grimm D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Dec;26(12):5124-40
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Dec;26(12):5124-40
In vivo, cardiac-specific knockdown of a target protein, malic enzyme-1, in rat via adenoviral delivery of DNA for non-native miRNA.
O'Donnell JM, Kalichira A, Bi J, Lewandowski ED
Current gene therapy 2012 Dec;12(6):454-62
Current gene therapy 2012 Dec;12(6):454-62
HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.
Ke L, Meijering RA, Hoogstra-Berends F, Mackovicova K, Vos MJ, Van Gelder IC, Henning RH, Kampinga HH, Brundel BJ
PloS one 2011;6(6):e20395
PloS one 2011;6(6):e20395
Functional duality of astrocytes in myelination.
Nash B, Thomson CE, Linington C, Arthur AT, McClure JD, McBride MW, Barnett SC
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Sep 14;31(37):13028-38
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Sep 14;31(37):13028-38
A novel luciferase and GFP dual reporter virus for rapid and convenient evaluation of hepatitis C virus replication.
Wu Y, Liao Q, Yang R, Chen X, Chen X
Virus research 2011 Feb;155(2):406-14
Virus research 2011 Feb;155(2):406-14
Presynaptic stimulus-release and postsynaptic compensatory changes in mice lacking the N-type calcium channel α(1B)-subunit.
Petrashevskaya NN, Ishii M, D'Souza K, Koch SE, Fuller-Bicer GA, Schwartz A
Autonomic neuroscience : basic & clinical 2011 Feb 24;160(1-2):9-15
Autonomic neuroscience : basic & clinical 2011 Feb 24;160(1-2):9-15
Role of checkpoint kinase 1 (Chk1) in the mechanisms of resistance to histone deacetylase inhibitors.
Lee JH, Choy ML, Ngo L, Venta-Perez G, Marks PA
Proceedings of the National Academy of Sciences of the United States of America 2011 Dec 6;108(49):19629-34
Proceedings of the National Academy of Sciences of the United States of America 2011 Dec 6;108(49):19629-34
Characterization of human chondrocytes exposed to simulated microgravity.
Ulbrich C, Westphal K, Pietsch J, Winkler HD, Leder A, Bauer J, Kossmehl P, Grosse J, Schoenberger J, Infanger M, Egli M, Grimm D
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;25(4-5):551-60
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;25(4-5):551-60
Induction of glucocorticoid receptor-beta expression in epithelial cells of asthmatic airways by T-helper type 17 cytokines.
Vazquez-Tello A, Semlali A, Chakir J, Martin JG, Leung DY, Eidelman DH, Hamid Q
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2010 Sep;40(9):1312-22
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2010 Sep;40(9):1312-22
Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents.
Namdar M, Perez G, Ngo L, Marks PA
Proceedings of the National Academy of Sciences of the United States of America 2010 Nov 16;107(46):20003-8
Proceedings of the National Academy of Sciences of the United States of America 2010 Nov 16;107(46):20003-8
Application of free-flow IEF to identify protein candidates changing under microgravity conditions.
Pietsch J, Kussian R, Sickmann A, Bauer J, Weber G, Nissum M, Westphal K, Egli M, Grosse J, Schönberger J, Wildgruber R, Infanger M, Grimm D
Proteomics 2010 Mar;10(5):904-13
Proteomics 2010 Mar;10(5):904-13
The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell.
Bialkowska K, Ma YQ, Bledzka K, Sossey-Alaoui K, Izem L, Zhang X, Malinin N, Qin J, Byzova T, Plow EF
The Journal of biological chemistry 2010 Jun 11;285(24):18640-9
The Journal of biological chemistry 2010 Jun 11;285(24):18640-9
Ca(2+)/calmodulin-dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na(+)/H(+) exchanger activation.
Vila-Petroff M, Mundiña-Weilenmann C, Lezcano N, Snabaitis AK, Huergo MA, Valverde CA, Avkiran M, Mattiazzi A
Journal of molecular and cellular cardiology 2010 Jul;49(1):106-12
Journal of molecular and cellular cardiology 2010 Jul;49(1):106-12
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice.
Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Arthur S, Xie M, Schneider MD, Zhai B, Gygi S, Davis R, Glimcher LH
The Journal of clinical investigation 2010 Jul;120(7):2457-73
The Journal of clinical investigation 2010 Jul;120(7):2457-73
Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells.
Kong D, Banerjee S, Ahmad A, Li Y, Wang Z, Sethi S, Sarkar FH
PloS one 2010 Aug 27;5(8):e12445
PloS one 2010 Aug 27;5(8):e12445
Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.
Lee JH, Choy ML, Ngo L, Foster SS, Marks PA
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 17;107(33):14639-44
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 17;107(33):14639-44
The effects of repeated allergen challenge on airway smooth muscle structural and molecular remodeling in a rat model of allergic asthma.
Labonté I, Hassan M, Risse PA, Tsuchiya K, Laviolette M, Lauzon AM, Martin JG
American journal of physiology. Lung cellular and molecular physiology 2009 Oct;297(4):L698-705
American journal of physiology. Lung cellular and molecular physiology 2009 Oct;297(4):L698-705
The JNK pathway amplifies and drives subcellular changes in tau phosphorylation.
Vogel J, Anand VS, Ludwig B, Nawoschik S, Dunlop J, Braithwaite SP
Neuropharmacology 2009 Oct-Nov;57(5-6):539-50
Neuropharmacology 2009 Oct-Nov;57(5-6):539-50
A citrus extract containing flavanones represses plasminogen activator inhibitor-1 (PAI-1) expression and regulates multiple inflammatory, tissue repair, and fibrosis genes in human colon fibroblasts.
Giménez-Bastida JA, Martínez-Florensa M, Espín JC, Tomás-Barberán FA, García-Conesa MT
Journal of agricultural and food chemistry 2009 Oct 14;57(19):9305-15
Journal of agricultural and food chemistry 2009 Oct 14;57(19):9305-15
Effects of TRPM8 on the proliferation and motility of prostate cancer PC-3 cells.
Yang ZH, Wang XH, Wang HP, Hu LQ
Asian journal of andrology 2009 Mar;11(2):157-65
Asian journal of andrology 2009 Mar;11(2):157-65
Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1.
González-Sarrías A, Azorín-Ortuño M, Yáñez-Gascón MJ, Tomás-Barberán FA, García-Conesa MT, Espín JC
Journal of agricultural and food chemistry 2009 Jun 24;57(12):5623-32
Journal of agricultural and food chemistry 2009 Jun 24;57(12):5623-32
Transcriptional activation of insulin-like growth factor binding protein 6 by 17beta-estradiol in SaOS-2 cells.
Zhao YY, Guo L, Zhao XJ, Liu H, Lei T, Ma DJ, Gao XY
Experimental & molecular medicine 2009 Jul 31;41(7):478-86
Experimental & molecular medicine 2009 Jul 31;41(7):478-86
TAK1 is an essential regulator of BMP signalling in cartilage.
Shim JH, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH
The EMBO journal 2009 Jul 22;28(14):2028-41
The EMBO journal 2009 Jul 22;28(14):2028-41
miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells.
Kong D, Li Y, Wang Z, Banerjee S, Ahmad A, Kim HR, Sarkar FH
Stem cells (Dayton, Ohio) 2009 Aug;27(8):1712-21
Stem cells (Dayton, Ohio) 2009 Aug;27(8):1712-21
Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation.
Ke L, Qi XY, Dijkhuis AJ, Chartier D, Nattel S, Henning RH, Kampinga HH, Brundel BJ
Journal of molecular and cellular cardiology 2008 Nov;45(5):685-93
Journal of molecular and cellular cardiology 2008 Nov;45(5):685-93
Vascular endothelial growth factor induces extracellular matrix proteins and osteopontin in the umbilical artery.
Infanger M, Grosse J, Westphal K, Leder A, Ulbrich C, Paul M, Grimm D
Annals of vascular surgery 2008 Mar;22(2):273-84
Annals of vascular surgery 2008 Mar;22(2):273-84
Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells.
Kong D, Wang Z, Sarkar SH, Li Y, Banerjee S, Saliganan A, Kim HR, Cher ML, Sarkar FH
Stem cells (Dayton, Ohio) 2008 Jun;26(6):1425-35
Stem cells (Dayton, Ohio) 2008 Jun;26(6):1425-35
Effects of basic fibroblast growth factor on endothelial cells under conditions of simulated microgravity.
Ulbrich C, Westphal K, Baatout S, Wehland M, Bauer J, Flick B, Infanger M, Kreutz R, Vadrucci S, Egli M, Cogoli A, Derradji H, Pietsch J, Paul M, Grimm D
Journal of cellular biochemistry 2008 Jul 1;104(4):1324-41
Journal of cellular biochemistry 2008 Jul 1;104(4):1324-41
Combination of peptide OFFGEL fractionation and label-free quantitation facilitated proteomics profiling of extraocular muscle.
Fraterman S, Zeiger U, Khurana TS, Rubinstein NA, Wilm M
Proteomics 2007 Sep;7(18):3404-16
Proteomics 2007 Sep;7(18):3404-16
Expression of vascular endothelial growth factor and receptor tyrosine kinases in cardiac ischemia/reperfusion injury.
Infanger M, Faramarzi S, Grosse J, Kurth E, Ulbrich C, Bauer J, Wehland M, Kreutz R, Kossmehl P, Paul M, Grimm D
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2007 Sep-Oct;16(5):291-9
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2007 Sep-Oct;16(5):291-9
Heart-specific inhibition of protooncogene c-myc attenuates cold-induced cardiac hypertrophy.
Bello Roufai M, Li H, Sun Z
Gene therapy 2007 Oct;14(19):1406-16
Gene therapy 2007 Oct;14(19):1406-16
Comparison of protective effects of trimetazidine against experimental warm ischemia of different durations: early and long-term effects in a pig kidney model.
Jayle C, Favreau F, Zhang K, Doucet C, Goujon JM, Hebrard W, Carretier M, Eugene M, Mauco G, Tillement JP, Hauet T
American journal of physiology. Renal physiology 2007 Mar;292(3):F1082-93
American journal of physiology. Renal physiology 2007 Mar;292(3):F1082-93
Calcineurin in reactive astrocytes plays a key role in the interplay between proinflammatory and anti-inflammatory signals.
Fernandez AM, Fernandez S, Carrero P, Garcia-Garcia M, Torres-Aleman I
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Aug 15;27(33):8745-56
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Aug 15;27(33):8745-56
Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation.
Brundel BJ, Henning RH, Ke L, van Gelder IC, Crijns HJ, Kampinga HH
Journal of molecular and cellular cardiology 2006 Sep;41(3):555-62
Journal of molecular and cellular cardiology 2006 Sep;41(3):555-62
Reduced inotropic effect of nifekalant in failing hearts in rats.
Endo H, Miura M, Hirose M, Takahashi J, Nakano M, Wakayama Y, Sugai Y, Kagaya Y, Watanabe J, Shirato K, Shimokawa H
The Journal of pharmacology and experimental therapeutics 2006 Sep;318(3):1102-7
The Journal of pharmacology and experimental therapeutics 2006 Sep;318(3):1102-7
Induction of heat shock response protects the heart against atrial fibrillation.
Brundel BJ, Shiroshita-Takeshita A, Qi X, Yeh YH, Chartier D, van Gelder IC, Henning RH, Kampinga HH, Nattel S
Circulation research 2006 Dec 8;99(12):1394-402
Circulation research 2006 Dec 8;99(12):1394-402
Calpain inhibition prevents pacing-induced cellular remodeling in a HL-1 myocyte model for atrial fibrillation.
Brundel BJ, Kampinga HH, Henning RH
Cardiovascular research 2004 Jun 1;62(3):521-8
Cardiovascular research 2004 Jun 1;62(3):521-8
Increased expression of cardiac angiotensin II type 1 (AT(1)) receptors decreases myocardial microvessel density after experimental myocardial infarction.
de Boer RA, Pinto YM, Suurmeijer AJ, Pokharel S, Scholtens E, Humler M, Saavedra JM, Boomsma F, van Gilst WH, van Veldhuisen DJ
Cardiovascular research 2003 Feb;57(2):434-42
Cardiovascular research 2003 Feb;57(2):434-42
LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer.
Abdollahi A, Pisarcik D, Roberts D, Weinstein J, Cairns P, Hamilton TC
The Journal of biological chemistry 2003 Feb 21;278(8):6041-9
The Journal of biological chemistry 2003 Feb 21;278(8):6041-9
Activation of proteolysis by calpains and structural changes in human paroxysmal and persistent atrial fibrillation.
Brundel BJ, Ausma J, van Gelder IC, Van der Want JJ, van Gilst WH, Crijns HJ, Henning RH
Cardiovascular research 2002 May;54(2):380-9
Cardiovascular research 2002 May;54(2):380-9
Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation: differential regulation of protein and mRNA levels for K+ channels.
Brundel BJ, Van Gelder IC, Henning RH, Tuinenburg AE, Wietses M, Grandjean JG, Wilde AA, Van Gilst WH, Crijns HJ
Journal of the American College of Cardiology 2001 Mar 1;37(3):926-32
Journal of the American College of Cardiology 2001 Mar 1;37(3):926-32
Ion channel remodeling is related to intraoperative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation.
Brundel BJ, Van Gelder IC, Henning RH, Tieleman RG, Tuinenburg AE, Wietses M, Grandjean JG, Van Gilst WH, Crijns HJ
Circulation 2001 Feb 6;103(5):684-90
Circulation 2001 Feb 6;103(5):684-90
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Supportive validation
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- Western blot analysis of GAPDH was performed by loading 20 µg of THP-1 whole cell lysates per well onto an SDS-PAGE gel. Proteins were transferred to a PVDF membrane and blocked with 5% milk in TBST. The membrane was probed with a GAPDH loading control monoclonal antibody (Product # MA5-15738) at a dilution of 1:5000 overnight at 4°C, washed in TBST, and probed with a HRP-conjugated goat anti-mouse IgG at a dilution of 1:40,000 for 1 hr at room temperature. Detection was performed using ECL substrate. Data courtesy of the Innovators Program.
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- 1:2000 (0.5 µg/mL) Ab dilution used in WB of 5 µg/lane tissue lysates from human (1), mouse (2), rat (3), rabbit (4), chicken (5), and hamster (6).
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- WB from BL-21 bacteria (1), Sf9 insect (2), and Saccharomyces cerevisiae (3)
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- Western blot analysis was performed on whole cell extracts (30µg lysate) of A-431 (Lane 1), COS-7 (Lane 2), MDCK (Lane 3), C2C12 (Lane 4), PC-3 (Lane 5), PC-12 (Lane 6), Neuro-2a (Lane 7) and tissue extract (30µg lysate) of Rat Heart (Lane 8). The blots were probed with Anti-GAPDH Mouse Monoclonal Antibody (Product # MA5-15738-1MG, 1:4000 dilution) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.25µg/mL, 1:4000 dilution). A 37 kDa band corresponding to GAPDH was observed across the cell lines and tissue tested. Known quantity of protein samples were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0321BOX), XCell SureLock™ Electrophoresis System (Product # EI0002) and Novex® Sharp Pre-Stained Protein Standard (Product # LC5800). Resolved proteins were then transferred onto a nitrocellulose membrane with iBlot® 2 Dry Blotting System (Product # IB21001). The membrane was probed with the relevant primary and secondary Antibody following blocking with 5 % skimmed milk. Chemiluminescent detection was performed using Pierce™ ECL Western Blotting Substrate (Product # 32106).
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- Western blot analysis was performed on whole cell extracts (30µg lysate) of A-431 (Lane 1), COS-7 (Lane 2), MDCK (Lane 3), C2C12 (Lane 4), PC-3 (Lane 5), PC-12 (Lane 6), Neuro-2a (Lane 7) and tissue extract (30µg lysate) of Rat Heart (Lane 8). The blots were probed with Anti-GAPDH Mouse Monoclonal Antibody (Product # MA5-15738-1MG, 1:4000 dilution) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.25µg/mL, 1:4000 dilution). A 37 kDa band corresponding to GAPDH was observed across the cell lines and tissue tested. Known quantity of protein samples were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0321BOX), XCell SureLock™ Electrophoresis System (Product # EI0002) and Novex® Sharp Pre-Stained Protein Standard (Product # LC5800). Resolved proteins were then transferred onto a nitrocellulose membrane with iBlot® 2 Dry Blotting System (Product # IB21001). The membrane was probed with the relevant primary and secondary Antibody following blocking with 5 % skimmed milk. Chemiluminescent detection was performed using Pierce™ ECL Western Blotting Substrate (Product # 32106).
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- Immunofluorescent analysis of GAPDH (green) showing staining in the in the cytoplasm of Hela cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a GAPDH loading control antibody (Product # MA5-15738) in 3% BSA-PBS at a dilution of 1:100 and incubated overnight at 4ºC in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody in PBS at room temperature in the dark. F-actin (red) was stained with a fluorescent red phalloidin and nuclei (blue) were stained with Hoechst or DAPI. Images were taken at a magnification of 60x.
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- Immunofluorescent analysis of GAPDH (green) showing staining in the in the cytoplasm of MCF-7 cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a GAPDH loading control antibody (Product # MA5-15738) in 3% BSA-PBS at a dilution of 1:100 and incubated overnight at 4ºC in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody in PBS at room temperature in the dark. Nuclei (blue) were stained with Hoechst or DAPI. Images were taken at a magnification of 60x.
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- Immunofluorescent analysis of GAPDH (green) showing staining in the in the cytoplasm of C2C12 cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a GAPDH loading control antibody (Product # MA5-15738) in 3% BSA-PBS at a dilution of 1:100 and incubated overnight at 4ºC in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody in PBS at room temperature in the dark. F-actin (red) was stained with a fluorescent red phalloidin and nuclei (blue) were stained with Hoechst or DAPI. Images were taken at a magnification of 60x.
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- Immunofluorescent analysis of GAPDH (green) in HeLa. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 5% normal goat serum (Product # 31873) for 15 minutes at room temperature. Cells were probed with a GAPDH monoclonal antibody (Product # MA5-15738) at a dilution of 1:100 for at least 1 hour at room temperature, washed with PBS, and incubated with DyLight 488 goat anti-mouse IgG secondary antibody (Product # 35502) at a dilution of 1:400 for 30 minutes at room temperature. Nuclei (blue) were stained with Hoechst 33342 dye (Product # 62249). Images were taken on a Thermo Scientific ArrayScan or ToxInsight Instrument at 20X magnification.
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- Immunohistochemistry analysis of GAPDH showing staining in the nucleus and cytoplasm of paraffin-embedded human breast carcinoma (right) compared with a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then probed with a GAPDH monoclonal antibody (Product # MA5-15738) diluted in 3% BSA-PBS at a dilution of 1:200 overnight at 4°C in a humidified chamber. Tissues were washed extensively in PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.
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- Immunohistochemistry analysis of GAPDH showing staining in the nucleus and cytoplasm of paraffin-embedded mouse colon tissue (right) compared with a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then probed with a GAPDH monoclonal antibody (Product # MA5-15738) diluted in 3% BSA-PBS at a dilution of 1:100 overnight at 4°C in a humidified chamber. Tissues were washed extensively in PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.
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- Immunohistochemistry analysis of GAPDH showing staining in the nucleus and cytoplasm of paraffin-embedded human kidney tissue (right) compared with a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then probed with a GAPDH monoclonal antibody (Product # MA5-15738) diluted in 3% BSA-PBS at a dilution of 1:100 overnight at 4°C in a humidified chamber. Tissues were washed extensively in PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.
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- Flow cytometry analysis of GAPDH in NIH-3T3 cells (green) compared to an isotype control (blue). Cells were harvested, adjusted to a concentration of 1-5x10^6 cells/mL, fixed with 2% paraformaldehyde and washed with PBS. Cells were blocked with a 2% solution of BSA-PBS for 30 min at room temperature and incubated with a GAPDH loading control antibody (Product # MA5-15738) at a dilution of 2 µg/test for 40 min at room temperature. Cells were then incubated for 40 min at room temperature in the dark using a Dylight 488-conjugated secondary antibody and re-suspended in PBS for FACS analysis.
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- Flow cytometry analysis of GAPDH in Hela cells (green) compared to an isotype control (blue). Cells were harvested, adjusted to a concentration of 1-5x10^6 cells/mL, fixed with 2% paraformaldehyde and washed with PBS. Cells were blocked with a 2% solution of BSA-PBS for 30 min at room temperature and incubated with a GAPDH loading control antibody (Product # MA5-15738) at a dilution of 2 µg/test for 40 min at room temperature. Cells were then incubated for 40 min at room temperature in the dark using a Dylight 488-conjugated secondary antibody and re-suspended in PBS for FACS analysis.
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- Flow cytometry analysis of GAPDH in MCF-7 cells (green) compared to an isotype control (blue). Cells were harvested, adjusted to a concentration of 1-5x10^6 cells/mL, fixed with 2% paraformaldehyde and washed with PBS. Cells were blocked with a 2% solution of BSA-PBS for 30 min at room temperature and incubated with a GAPDH loading control antibody (Product # MA5-15738) at a dilution of 2 µg/test for 40 min at room temperature. Cells were then incubated for 40 min at room temperature in the dark using a Dylight 488-conjugated secondary antibody and re-suspended in PBS for FACS analysis.
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- Flow cytometry analysis of GAPDH in NIH-3T3 cells (green) compared to an isotype control (blue). Cells were harvested, adjusted to a concentration of 1-5x10^6 cells/mL, fixed with 2% paraformaldehyde and washed with PBS. Cells were blocked with a 2% solution of BSA-PBS for 30 min at room temperature and incubated with a GAPDH loading control antibody (Product # MA5-15738) at a dilution of 2 µg/test for 40 min at room temperature. Cells were then incubated for 40 min at room temperature in the dark using a Dylight 488-conjugated secondary antibody and re-suspended in PBS for FACS analysis.
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- Fig. 5 OTUD1 inhibits nuclear localization and transcriptional activity of YAP. a Upper panel: immunoblotting of OTUD1 and GAPDH in HEK293A, BT549, and LM2 cell lines. Lower panel: immunoblotting of FLAG-OTUD1 and GAPDH in LM2 cells stably transfected with SFB-OTUD1. b LM2 cells stably overexpressing OTUD1 were immunostained with a YAP-specific antibody (red). DAPI (blue) was used to stain DNA. Scale bar, 20 mum. c , d HEK293A cells expressing OTUD1 shRNA ( c ) or gRNA ( d ) were immunostained with a YAP-specific antibody (red in c ; green in d ). DAPI (blue) was used to stain DNA. Scale bar, 20 mum. e - g qPCR of ANKRD1 , CTGF , and CYR61 in BT549 cells expressing HA-OTUD1 ( e ) and in HEK293A cells expressing OTUD1 shRNA ( f ) or OTUD1 gRNA ( g , left panel). Right panel in g : immunoblotting of OTUD1 and GAPDH in two independent OTUD1 knockout HEK293A clones generated by CRISPR-Cas9. n = 3 biological replicates. Error bars in e - g are s.e.m. Statistical significance was determined by a two-tailed, unpaired Student's t -test. * P < 0.05; ** P < 0.01; *** P < 0.001
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- Figure 5 EGFR/AKT/mTOR and beta-catenin signaling in glioblastoma cells after treated with nanoparticles. Notes: ( A ) Confocal microscope images of U87 and U118 cells actin cytoskeleton. Cells were grown on extracellular matrix for 24 h and treated with diamond nanoparticles, graphite nanoparticles, or graphene oxide nanoparticles at a concentration of 20 mug/mL and incubated for 24 h. F-Actin was stained with phalloidin conjugated with Atto 633. ( B ) Western blot analysis of N-cadherin, pan-cadherin, vinculin, p-EGFR, and EGFR. GAPDH was used as a loading control. ( C ) Western blot analysis of nuclear and cytoplasmic protein fractions used for determination of beta-catenin protein level. PCNA and beta-tubulin were used as loading controls for nuclear and cytoplasmic fractions, respectively. ( D ) ELISA analysis of AKT and mTOR phosphorylation in comparison to control. Treatment with nanoparticles significantly reduced phospho-AKT ( P
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- Figure 2--figure supplement 2. Analysis of RNA and protein expression levels of the major cardiac Ca 2+ -handling proteins in PLN/DWORF Tg mice. ( A ) RNA levels of the indicated genes as quantified by qRT-PCR in 16-week-old heart tissue. Atp2a2 , SERCA2a; Ryr2 , ryanodine receptor 2; Cacna1c, alpha1C-subunit of the L-type Ca 2+ channel; Casq2 , calsequestrin 2. Data are normalized to 18S and presented as expression level relative to WT, mean +-SD for n = 10 mice per genotype. ( B ) Representative immunoblots of cardiac homogenates from mice with the indicated genotypes. PS16, phospho-serine 16 on PLN; PT17, phospho-threonine 17 on PLN; tPLN, total phospholamban; RyR2, ryanodine receptor 2; LTCC, L-type Ca 2+ channel (alpha1C-subunit); Casq2, calsequestrin 2; GAPDH, glyceraldehyde 3-phosphate dehydrogenase. ( C ) Western blots for n = 9-10 mice of each genotype were quantified using ImageJ and data are normalized to GAPDH and expressed as mean +-SD relative to WT. ( D ) Quantification of total phospholamban and its phosphorylation status as assessed by western blot ( B ) and expressed as relative to WT. Western blots were quantified with ImageJ software. Phosphorylation blots (PS16 and PT17) were normalized to total PLN (tPLN). Total PLN was normalized to GAPDH. Data are expressed as mean +-SD for n = 9-10 mice per genotype. Statistical comparisons between groups were evaluated by Student's t-test. p-value *p
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- Figure 6--figure supplement 1. Expression and post-translational modifications of Ca 2+ -handling proteins. ( A ) Immunoblots of cardiac homogenates from mice with the indicated genotypes. ( B ) Immunoblots were quantified using ImageJ and normalized to GAPDH. LTCC, L-type Ca 2+ channel (alpha1C-subunit); Casq2, calsequestrin 2; RyR2, ryanodine receptor 2; GAPDH, glyceraldehyde 3-phosphate dehydrogenase. ( C ) Quantification of the phosphorylation status and oligomerization of phospholamban as assessed by western blot (panel A ) and expressed as relative to WT. Western blots were quantified with ImageJ software. Phosphorylation blots (PS16 and PT17) were normalized to total PLN (tPLN). Total PLN was normalized to GAPDH. tPLN, total phospholamban; PS16, phospho-serine 16 on PLN; PT17, phospho-threonine 17 on PLN. Data are expressed as mean +-SD for n = 4-6 mice per genotype. ( D ) RNA levels of the indicated genes as quantified by qRT-PCR in 8-week-old heart tissue. Atp2a2 , SERCA2a; Cacna1c, alpha1C-subunit of the L-type Ca 2+ channel; Casq2 , calsequestrin 2; Pln , phosholamban; Ryr2 , ryanodine receptor 2. Data are normalized to 18S values and presented as expression level relative to WT, mean +-SD for n = 4-5 mice per genotype.
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- Figure 3. Mag1 protein expression and MAG1 mRNA expression are reduced in tH2A:tH3 cells. WT and the N-tail deletion mutants were treated with 0.2% MMS for 10 min and further analyzed at the indicated time points. ( A ) Mag1 9myc and GAPDH were detected via western blotting. ( B ) A northern blot detecting MAG1 and reprobed for RDN18 . [We note that the small band shift between the tH3(60') sample and the tH2A:tH3 samples is due to a gel running artifact]. ( C ) Quantification of different gels, such as shown in (B) by normalizing MAG1 levels to that of WT in the absence of MMS. Error bars indicate standard deviations derived from three independent experiments.
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- Figure 6. The N-tails of H2A and H3 are epistatic to RAD18 . ( A ) Epistasis studies of (i) N-tail deletion mutants combinatorially deleted for (ii) MAG1 , (iii) REV3 , (iv) RAD5 and (v) RAD18 . ( B ) Epistasis study of N-tail deletion mutants combinatorially deleted for RAD52 . ( C ) MMS survival assay of WT and N-tail mutants (solid lines) and the N-tail mutants combinatorially deleted for RAD18 (dashed lines). ( D ) Growth curves of the cells in ( C ) in the absence of MMS. ( E ) Western blot of PCNA 9myc in WT and N-tail mutants before UV exposure and after a 1 h recovery in YPD following 100 J/m 2 of UV irradiation. GAPDH is used as the loading control. rad6Delta serves as a negative control for PCNA ubiquitylation. ( F ) Quantifications of (E) by normalizing (PCNA 9myc -ub)/(PCNA 9myc -total) and (PCNA 9myc -ub 2 )/(PCNA 9myc -total) to WT. Error bars indicate standard deviations from three independent experiments.
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- Figure 1 Expression of two critical components of the UPR, BiP and CHOP are blocked by L. pneumophila ( a ) Caspase 1/11 (-/-) bone marrow derived macrophages or ( b ) HEK-293 FCgamma cells-expressing Fc gamma (HEK-293 FCgamma) were either left uninfected or infected with WT or DeltadotA strains of L. pneumophila at an MOI of 150. Cells were then left untreated or treated with thapsigargin (Tg; 1 mug mul -1 ) for 6 h. BiP, CHOP and PDI protein expression were monitored via immunoblot. GAPDH was used as a loading control. Full blots are provided for Fig. 1a,b in Supplementary Fig. 5 . ( c , d ) BiP and CHOP levels were quantified respectively from three biological replicates using the same experimental conditions in HEK-293 FCgamma cells. Data are depicted as the fold change normalized to uninfected levels. Data represent three independent experiments. Values in all graphs are means+-s.e.m. * P
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- Figure 3 Suppression of ER stress is an effector driven process that is independent of the mTOR pathway. ( a - c ) HEK-293 FCgamma cells were either left uninfected or infected with WT L. pneumophila or DeltadotA L. pneumophila at an MOI of 150. Cells were then either left untreated or treated with thapsigargin (Tg; 1 mug mul -1 ) or treated with a combination of Tg and the antibiotic Rifampicin (Rif.; 2 mug mul -1 ) for 6 h. After 6 h phase contrast images were taken. ( d ) HEK-293 FCgamma cells were infected at an MOI of 150 with WT L. pneumophila , or left uninfected. Cells were then treated with Rif. alone (2 mug mul -1 ), Rif. with Tg (1 mug mul -1 ), Tg (1 mug mul -1 ) alone or left untreated for 6 h. BiP protein levels were monitored via immunoblot. ( e ) HEK-293 FCgamma cells were untreated or treated with rapamycin (10 nM) or rapamycin with Tg (1 mug mul -1 ) for 6 h. BiP protein levels were then monitored via immunoblot and levels of phosphorylated Akt at serine 473 (P-Akt) were monitored from these lysates via immunoblot. ( f ) RAW 264.7 cells were infected with WT L. pneumophila, dotA , or Delta 5 strains of L. pneumophila at an MOI of 150. BiP protein expression was monitored via immunoblot. GAPDH was used as a loading control. Full blots for Fig. 3d-f are provided in Supplementary Fig. 5 .
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- Figure 6 ATF6 is processed during L. pneumophila infection. ( a ) RAW 264.7 cells were left uninfected or infected with either WT L. pneumophila , DeltadotA , B. Delta5, Delta5+plgt2, or Delta5 plgt2* (catalytically dead lgt2) at an MOI of 150. Cells were then left untreated or treated with thapsigargin (Tg; 1 mug mul -1 ) for 6 h. Full-length ATF6 (pATF6) and cleaved pATF6(N) were monitored via immunoblot. Full blots for Fig. 6a are provided in Supplementary Fig. 5 . ( b ) HEK-293 FCgamma cells infected with either WT L. pneumophila or DeltadotA and then treated for 6 h with Tg (1 mug mul -1 ). Sel1L mRNA levels were then monitored via qRT-PCR, with GAPDH serving as an endogenous control. Two biological replicates were used each with three technical replicates using the identical experimental conditions. Values in all graphs are means+-s.e.m. * P
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- Figure 7. RBM15 directly recruits the intron-binding splicing factor, SF3B1, for alternative RNA splicing. ( A ) The interaction between SF3B1 and RBM15 in the context of PRMT1-mediated methylation. RBM15-Flag and RBM15 R578K-Flag expressed from two MEG-01 cell lines with or without DB75 treatment were immunoprecipitated with anti-Flag antibody for detecting interaction with SF3B1 by WB. ( B ) The endogenous SF3B1 was co-immunopreciptiated with anti-RBM15 antibody in MEG-01 cells expressing inducible shPRMT1. Normal mouse serum was used as a negative control. ( C ) RBM15 binding profile on GATA1 pre-mRNA based on RIP-seq data. The green peaks are the binding sites for RBM15 and the blue profile is the binding profile for normal IgG. Two biological replicates were used for bioinformatic analysis. The significant peaks were shaded with pink squares. ( D ) The regions where RBM15 (RIP with RBM15 antibody, left panel) and SF3B1 (RIP with SF3B1 antibody right panel) bound on GATA1 pre-mRNA in MEG-01 cells (solid bar) and RBM15 knockdown MEG-01 cells (open bar) were mapped by real-time PCR assays. The locations of primers on the pre-mRNA of GATA1 were shown on the bottom. Three biological replicates were used to calculate the standard deviations. GAPDH intron 1 was used as negative controls for both antibodies. ( E ) The regions on c-MPL pre-mRNA, where RBM15 and SF3B1 bound in MEG-01 cell lines expressing shRBM15 (square line) or expressing pLKO vector (solid dot line), were asses
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- Figure 6 Generation of a drug-controllable ""SMAShable"" measles vaccine virus. (a) Concept of controlling MeV replication with P-SMASh. In the absence of the drug, essentially unmodified phosphoprotein (P, blue) is released and can successfully form replication complexes with nucleocapsid (N, orange) and large (L) proteins. (b) Genome organization of MeV-EGFP-P-SMASh. Scale bar is 1 kilobase. (c) Regulation of MeV-EGFP-P-SMASh by drug. Vero cells infected with MeV-EGFP or MeV-EGFP-P-SMASh at multiplicity of infection (MOI) of 1 were grown for 72 h in the absence or presence of ASV. Drug inhibited syncytium formation and GFP expression in MeV-EGFP-P-SMASh-infected but not MeV-EGFP-infected cells. Scale bar, 50 mum. (d) Quantification of fluorescence from Vero cells infected with MeV-EGFP-P-SMASh at MOI 1 and 0.1 in the absence or presence of 3 muM ASV ( n = 3, error bars are standard deviation). (e) Drug inhibited P expression in MeV-EGFP-P-SMASh-infected but not MeV-EGFP-infected cells, as assayed by immunoblotting. GAPDH served as a loading control.
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- Figure 7 Overexpression of Rab11Fip5 in NK-92 Cells Increases Cytokine and Granzyme Release (A) Effect of Rab11Fip5 overexpression on IFN-gamma production and degranulation (CD107a expression) of NK-92 cells in response to stimulation with PMA/ionomycin. NK-92/Rab11Fip5 (red symbols) and NK-92/ZsGreen cells (blue symbols) were stimulated with 500 ng/mL PMA and 5 mug/mL ionomycin for 2 hr in the presence of a CD107a antibody and the protein transport inhibitor monensin. Dots represent MFIs from 6 replicate wells. Significance determined by Wilcoxon-Mann-Whitney (ns, not significant; ** p < 0.01). (B) Granzyme B (GzB)-based cytotoxicity assays performed using NK-92/Rab11Fip5 (red) or NK-92/ZsGreen control (blue) cells as effectors and K562 cells as targets at different effector:target ratios. The percentage of cells positive for proteolytically active GzB is represented as % GzB activity. The average values from 3 independent experiments performed in triplicate are shown. (C) Western blot of Rab11Fip5 expression in NK-92 cells transduced with a RAB11FIP5 expression vector or zsGreen vector control, in the presence or absence of K562 target cell stimulation (5:1 effector:target ratio). Cells were analyzed at 10 hr post stimulation. GAPDH used as protein loading control. See also Figure S7 .
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- Figure 5. G. intestinalis secreted cysteine proteases have effects on epithelial barrier proteins. A, B, C. Levels of tight junction and adherence junction proteins in Caco-2 whole cell extracts were examined after 24 h of recombinant cysteine proteases treatment (A, 14019; B, 16779; C, 16160), respectively, by Western blot analysis, with GAPDH used as a loading control. Barrier proteins were detected with a mouse or rabbit anti-barrier protein antibody and then incubated with a HR- conjugated mouse or rabbit antibody. D E, F. The localization of occludin in Caco-2 cells visualized by immunofluorescence microscopy. Caco-2 monolayers were incubated with 2.5 ug/ml of 14019 (D), 16779 (E), 16160 (F) in the absence or presence of E64 (10 uM) for 24 h, followed by fixation of PFA. Occludin was detected with a mouse anti-occludin antibody and then incubated with an Alexa Fluor 488-conjugated mouse antibody. Images were taken by a Zeiss Axioplan II Imaging fluorescence microscope and analyzed by ZEN 2.1 software. Bar = 50 um.
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- Figure 5 Global protein translation inhibition does not the affect the UPR in the same manner as L. pneumophila infection. ( a ) RAW 264.7 cells were left untreated or treated with either thapsigargin (Tg; 1 mug mul -1 ), CHX (1 mug mul -1 ), or a combination of both for 6 h. Protein levels of UPR targets BiP, CHOP and PDI were monitored via immunoblot. ( b ) RAW267.4 macrophage cells were treated with CHX or left untreated and BiP and CHOP mRNA levels were monitored via qRT-PCR. Three internal replicates were performed, values in all graphs are means+-s.e.m. * P
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- Figure 6 Counteracting or normalizing ROS reduced Tam effect on PPAR gamma . ( a ) Western blotting analysis (left panel) of PPAR gamma in 3T3L1 adipocytes after 48-h treatment with Tam (128 mu M) or Tam (128 mu M) plus NAC (1 mM), with densitometric analysis (right panel) of western blotting images using the NIH ImageJ software; n =3-5. ( b ) At week 2 after Tam administration, western blotting (upper panel) was performed to analyze PPAR gamma , with densitometric analysis (lower panel) of western blotting images using the NIH ImageJ software; n =3-5. ( c ) At week 6 after Tam administration, western blotting (upper panel) was performed to analyze PPAR gamma , with densitometric analysis (lower panel) of western blotting images using the NIH ImageJ software; n =3-5. GAPDH (glyceraldehyde 3-phosphate dehydrogenase) was probed as a loading control. * P
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- Fig 1 E2F6 Activates BDH1 Expression in Neonatal Myocardium. ( A) Bdh1 (beta-hydroxybutyrate dehydrogenase 1) and Oxct1 (succinyl-CoA: 3-oxoacid-CoA transferase) transcript levels in Wt and Tg myocardium 7 days after birth. Expression is normalized to Gapdh . Results represent mean+-SEM values (n = 5-7). ( B) Representative immunoblots of protein from Wt and Tg mouse myocardium at post-natal day 1 (pups) and 6wks of age (adult) examined with the anti-BDH1 and anti-OXCT1. ( C) Densitometric quantification of BDH1 and OXCT1 expression from immunoblots. Expression is normalized against GAPDH. Results represent mean+-SEM values (n = 4). ( D) Immunoblot of protein from Wt and Tg myocardium with BDH1 at the indicated time points after birth.* P
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- Fig 5 beta-OHB Regulates CX-43 Protein Expression in Neonatal Cardiomyocytes. ( A) Representative immunoblot of protein isolated from Wt and Tg myocardium at post-natal day 1 with anti-CX-43. ( B) Densitometric quantification of CX-43 immunoblot. Expression is normalized against GAPDH. Results represent mean+-SEM values (n = 4). ( C) Representative immunoblot analyses of protein from Wt and Tg neonatal cardiomyocytes following incubation with or without beta-OHB (beta-hydroxybutyrate). ( D) Densitometric quantification of CX-43 in treated and non-treated neonatal cardiomyocytes. Expression is normalized against GAPDH. Results represent the mean+-SEM values (n = 3-5). A two-way ANOVA was used to measure statistical significance. ( E ) Representative immunoblot analysis of BDH1 in Wt and Tg neonatal cardiomyocytes. * P
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- Figure 4 Galectin-3s molecular way of action ( A ) Relative fold change of Runx-2 mRNA levels during osteogenic differentiation over a time course of 18 days. Runx-2 mRNA levels of Galectin-3 overexpressing (Gal3) (indicated in grey squares) or empty vector control transfected cells (C) (displayed by black dots) were evaluated by qPCR and normalized to GAPDH. Runx-2 mRNA transcription was significantly increased at day 4 of differentiation in Galectin-3 overexpressing ASCs (Gal3) compared to empty vector control transfected cells (C) Levels of empty vector control transfected cells are displayed as black dots and data obtained from Galectin-3 overexpressing cells as grey dots. ( B-C ) Spearman correlation of beta-Catenin protein levels before induction of osteogenic differentiation to ( B ) intracellular Galectin-3 levels or (C) corresponding mineralization capacity of ASCs. ( D ) Overexpression of Galectin-3 wild type (Gal3) and Serine-96 to Alanine (A) mutant compared to empty vector control transfected ASCs (C) was confirmed by Western blot. Galectin-3 as well as beta-Catenin protein levels have been normalized to GAPDH ( E-F ) ASCs overexpressing the Galectin-3 mutant (A) showed a significant reduction in their osteogenic differentiation capacity compared to Galectin-3 wild type (Gal3) overexpressing cells as analysed by ( E ) Alizarin Red S staining ( F ) ALP activity assay and ( G ) qPCR on Osteonectin. ( H-J ) ASCs were either untreated (untreated) or exposed to cell p
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- Figure 5 FA2H protein levels in undifferentiated Neuro2a cells. 20 ug total protein was loaded per sample on a 12% sodium dodecyl sulfate-polyacryl amide (SDS-PAA) gel. One representative out of at least three biologically independent experiments is displayed. Nim = nimodipine pre-treatment (20 uM); Nif = nifedipine pre-treatment (20 uM) nt = no drug pre-treatment; anti-FA2H = rabbit anti-FA2H antibody (1:1000); anti-GAPDH = mouse anti-GAPDH antibody (1:5000; loading control).
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- Figure 6 FA2H protein levels in undifferentiated Neuro2a cells. 20 ug total protein was on loaded per sample on a 12% SDS-PAA gel. One representative out of at least three biologically independent experiments is displayed. Nim = nimodipine pre-treatment (20 uM); Nif = nifedipine pre-treatment (20 uM) nt = no drug pre-treatment; anti-FA2H = rabbit anti-FA2H antibody (1:1000); anti-GAPDH = mouse anti-GAPDH antibody (1:5000; loading control).
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- Figure 1--figure supplement 3. Mapping the methylation site for RBM15. ( A ) Tandem mass spectrometry analysis for Flag-tagged RBM15 purified from 293T cells overexpressing RBM15-Flag. The arrow indicates the modified peptide. ( B ) Schematic diagram shows domains on RBM15. ( C ) Dot blot to test the antibody (Mono-R100 from Cell Signaling, Danvers, MA) recognizing monomethylated RBM15 peptide based on mass spectrometry analysis. Nitrocellulose membrane was spotted with peptides with no modification, with arginine mono-methylated or with arginine asymmetrically dimethylated. The peptide sequences were listed on the right side of the dot blot gel. ( D ) Dot blot to test the antibody (D4H5 from Cell Signaling) which recognizes asymmetrically dimethylated RBM15 peptide. Peptides were spotted in the same order as in panel C. ( E ) IP-WBwestern blot for RBM15 protein in Meg-01 cell lines expressing Flag-tagged RBM15 and Flag-tagged RBM15 R578K. Anti-monomethyl arginine antibody was used for immunoprecipitation and the ectopically expressed RBM15 proteins were detected by Flag antibody. ( F ) IP-western blotting assays for detecting methylated RBM15 and R3K mutant expressed in 293T cells. RBM15-R3K stands for RBM15 protein with all the arginines in the LYRDRDRD sequence mutated to lysines. ( G ) The in vitro methylation reaction with peptide (LYRDRDRDLY) incubated with purified PRMT1. H4 peptide (20 mer) was used as a positive control. The methylated peptide was detected by the D4H
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- Fig. 9. Direct interaction of DYRK1A and SYN1, phosphorylation of SYN1 by DYRK1A. (A) DYRK1A and SYN1 were immunoblotted following immunoprecipitation from wt mice brain extracts. DYRK1A or SYN1 present in the starting material (Input) were recovered in the IPs. SYN1 (74 kDa) was present in the DYRK1A IP and DYRK1A (85 kDa) was detected in the SYN1 IP, suggesting that these two proteins interact directly. Positive control of the SYN1 IP was performed using an anti-CAMKII antibody. As expected, CAMKII (50 kDa) was present in the SYN1 IP. DYRK1A IP also brought down CAMKII, suggesting complexes between SYN1, CAMKII and DYRK1A. (B) Sequence of SYN1 in the vicinity of Ser551 matches with the consensus DYRK1A phosphorylation site. Based on this sequence, three peptides were synthesized and used as potential substrates: SYN1, SYN1-S551A and SYN1-S553A. (C) Kinase activity of recombinant DYRK1A towards the three different SYN1peptides. SYN1 and SYN1-S553A peptides were phosphorylated at the same level as Woodtide by recombinant DYRK1A (71.7%+-5.2%, 70.1% and 78.4%+-11.4%, respectively). No significant catalytic activity was measured with the SYN1-S551A peptide (7.9%+-1.2%).