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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Western blot [1]
- Other assay [6]
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- Product number
- 44-806G - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100 µL
- Storage
- -20°C
Submitted references How ligand binds to the type 1 insulin-like growth factor receptor.
Heat stress acutely activates insulin-independent glucose transport and 5'-AMP-activated protein kinase prior to an increase in HSP72 protein in rat skeletal muscle.
α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation.
Insulin-like growth factor receptor-1 and nuclear factor κB are crucial survival signals that regulate caspase-3-mediated lens epithelial cell differentiation initiation.
In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking.
In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors.
Xu Y, Kong GK, Menting JG, Margetts MB, Delaine CA, Jenkin LM, Kiselyov VV, De Meyts P, Forbes BE, Lawrence MC
Nature communications 2018 Feb 26;9(1):821
Nature communications 2018 Feb 26;9(1):821
Heat stress acutely activates insulin-independent glucose transport and 5'-AMP-activated protein kinase prior to an increase in HSP72 protein in rat skeletal muscle.
Goto A, Egawa T, Sakon I, Oshima R, Ito K, Serizawa Y, Sekine K, Tsuda S, Goto K, Hayashi T
Physiological reports 2015 Nov;3(11)
Physiological reports 2015 Nov;3(11)
α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation.
Basu S, Rajakaruna S, De Arcangelis A, Zhang L, Georges-Labouesse E, Menko AS
The Journal of biological chemistry 2014 Feb 14;289(7):3842-55
The Journal of biological chemistry 2014 Feb 14;289(7):3842-55
Insulin-like growth factor receptor-1 and nuclear factor κB are crucial survival signals that regulate caspase-3-mediated lens epithelial cell differentiation initiation.
Basu S, Rajakaruna S, Menko AS
The Journal of biological chemistry 2012 Mar 9;287(11):8384-97
The Journal of biological chemistry 2012 Mar 9;287(11):8384-97
In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking.
Cai EP, Casimir M, Schroer SA, Luk CT, Shi SY, Choi D, Dai XQ, Hajmrle C, Spigelman AF, Zhu D, Gaisano HY, MacDonald PE, Woo M
Diabetes 2012 Jul;61(7):1708-18
Diabetes 2012 Jul;61(7):1708-18
In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors.
Wu JD, Odman A, Higgins LM, Haugk K, Vessella R, Ludwig DL, Plymate SR
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Apr 15;11(8):3065-74
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Apr 15;11(8):3065-74
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western Blot using IR/IGF1R (pYpYpY1158/1162/1163) Polyclonal Antibody, Rabbit
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 5 Short-term HS does not affect insulin signaling or CaMKII in isolated skeletal muscle. Isolated epitrochlearis muscle was incubated in medium for 0 (control), 10, or 30 min at 42degC. Muscle was also incubated in the presence of 1 mumol/L insulin for 30 min at 35degC or contracted by electrical stimulation (ES) at 35degC. Muscle was subjected to Western blot analysis for phosphorylated IR (A), phosphorylated Akt (B), or phosphorylated CaMKII (C). Fold increases are expressed relative to the level in muscles of the control group. The values are mean +- SD; n = 5-6 (A), 6-7 (B), and 3-14 (C). * P < 0.05 versus corresponding control. Representative immunoblots are shown.
