Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations [0]
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- Product number
- M00127 - Provider product page
- Provider
- Boster Biological Technology
- Product name
- Anti-Parkin PARK2 Rabbit Monoclonal Antibody
- Antibody type
- Monoclonal
- Description
- Monoclonal antibody for PARK2 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: Flow Cytometry, IP, IF, IHC, ICC, WB. Reactive species: Human, Mouse, Rat PARK2 information: Molecular Weight: 51641 MW; Subcellular Localization: Cytoplasm, cytosol . Nucleus. Endoplasmic reticulum. Mitochondrion . Mainly localizes in the cytosol. Co-localizes with SYT11 in neutrites. Co-localizes with SNCAIP in brainstem Lewy bodies. Mitochondrial localization gradually increases with cellular growth. Also relocates to dysfunctional mitochondria that have lost the mitochondrial membrane potential; recruitment to mitochondria is PINK1- dependent; Tissue Specificity: Highly expressed in the brain including the substantia nigra. Expressed in heart, testis and skeletal muscle. Expression is down-regulated or absent in tumor biopsies, and absent in the brain of PARK2 patients. Overexpression protects dopamine neurons from kainate-mediated apoptosis. Found in serum (at protein level).
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Antibody clone number
- AOCD-16
- Vial size
- 100ug/vial
- Concentration
- 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
- Storage
- Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Submitted references Ruthenium red alleviates post-resuscitation myocardial dysfunction by upregulating mitophagy through inhibition of USP33 in a cardiac arrest rat model.
Study on the neuroprotective effect of Zhimu-Huangbo extract on mitochondrial dysfunction in HT22 cells induced by D-galactose by promoting mitochondrial autophagy.
PRKAA1 induces aberrant mitophagy in a PINK1/Parkin-dependent manner, contributing to fluoride-induced developmental neurotoxicity.
Robust intervention for oxidative stress-induced injury in periodontitis via controllably released nanoparticles that regulate the ROS-PINK1-Parkin pathway.
Punicalagin Protects against Diabetic Liver Injury by Upregulating Mitophagy and Antioxidant Enzyme Activities.
Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia.
Zhang F, Ye Z, Ran Y, Liu C, Zhang M, Xu X, Song F, Yao L
European journal of pharmacology 2024 Jul 5;974:176633
European journal of pharmacology 2024 Jul 5;974:176633
Study on the neuroprotective effect of Zhimu-Huangbo extract on mitochondrial dysfunction in HT22 cells induced by D-galactose by promoting mitochondrial autophagy.
Xue A, Zhao D, Zhao C, Li X, Yang M, Zhao H, Zhao C, Lei X, Wu J, Zhang N
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117012
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117012
PRKAA1 induces aberrant mitophagy in a PINK1/Parkin-dependent manner, contributing to fluoride-induced developmental neurotoxicity.
Tang Y, Zhang J, Hu Z, Xu W, Xu P, Ma Y, Xing H, Niu Q
Ecotoxicology and environmental safety 2023 Apr 15;255:114772
Ecotoxicology and environmental safety 2023 Apr 15;255:114772
Robust intervention for oxidative stress-induced injury in periodontitis via controllably released nanoparticles that regulate the ROS-PINK1-Parkin pathway.
Li X, Zhao Y, Peng H, Gu D, Liu C, Ren S, Miao L
Frontiers in bioengineering and biotechnology 2022;10:1081977
Frontiers in bioengineering and biotechnology 2022;10:1081977
Punicalagin Protects against Diabetic Liver Injury by Upregulating Mitophagy and Antioxidant Enzyme Activities.
Zhang Y, Tan X, Cao Y, An X, Chen J, Yang L
Nutrients 2022 Jul 6;14(14)
Nutrients 2022 Jul 6;14(14)
Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia.
Song JX, Zhao YS, Zhen YQ, Yang XY, Chen Q, An JR, Ji ES
Pharmaceutical biology 2022 Dec;60(1):609-620
Pharmaceutical biology 2022 Dec;60(1):609-620
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