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Other assayAntibody data
- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Other assay [2]
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- Product number
- 16-9243-85 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- TGF beta-1,2,3 Monoclonal Antibody (1D11.16.8), Functional Grade, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The monoclonal antibody 1D11.16.8 recognizes human, mouse, rat, hamster, canine and non-human primate Transforming Growth Factor (TGF) beta 1, 2 and 3. TGF beta is a pleiotropic cytokine that exists as five isoforms (TGF beta 1-5) that share 70-80% homology with each other. However, these isoforms are not homologous to TGF alpha. TGF beta 1 is highly conserved between human, murine, simian, bovine, porcine, and chicken proteins. TGF beta 1 is the most abundant isoform and is ubiquitously expressed by a variety of cell types, including platelets, macrophages, lymphocytes, endothelial cells, chondrocytes, and leukemic cells. However, the other isoforms exhibit a more restricted expression pattern.
- Antibody clone number
- 1D11.16.8
- Concentration
- 1 mg/mL
Submitted references Uncovering a Key Role of ETS1 on Vascular Abnormality in Glioblastoma.
TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment.
CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD.
E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
Cholera Toxin Promotes Th17 Cell Differentiation by Modulating Expression of Polarizing Cytokines and the Antigen-Presenting Potential of Dendritic Cells.
Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma.
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis.
Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation.
Cyclosporine induces cancer progression by a cell-autonomous mechanism.
Increased renal tubular expression of transforming growth factor beta in human allografts correlates with cyclosporine toxicity.
Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification.
Tang J, Li Y, Liu B, Liang W, Hu S, Shi M, Zeng J, Li M, Huang M
Pathology oncology research : POR 2021;27:1609997
Pathology oncology research : POR 2021;27:1609997
TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment.
Le BV, Podszywalow-Bartnicka P, Maifrede S, Sullivan-Reed K, Nieborowska-Skorska M, Golovine K, Yao JC, Nejati R, Cai KQ, Caruso LB, Swatler J, Dabrowski M, Lian Z, Valent P, Paietta EM, Levine RL, Fernandez HF, Tallman MS, Litzow MR, Huang J, Challen GA, Link D, Tempera I, Wasik MA, Piwocka K, Skorski T
Cell reports 2020 Oct 6;33(1):108221
Cell reports 2020 Oct 6;33(1):108221
CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD.
Imura Y, Ando M, Kondo T, Ito M, Yoshimura A
JCI insight 2020 Jul 23;5(14)
JCI insight 2020 Jul 23;5(14)
E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
Wang Z, Zhao M, Yin J, Liu L, Hu L, Huang Y, Liu A, Ouyang J, Min X, Rao S, Zhou W, Wu H, Yoshimura A, Lu Q
The Journal of clinical investigation 2020 Jul 1;130(7):3717-3733
The Journal of clinical investigation 2020 Jul 1;130(7):3717-3733
Cholera Toxin Promotes Th17 Cell Differentiation by Modulating Expression of Polarizing Cytokines and the Antigen-Presenting Potential of Dendritic Cells.
Kang JO, Lee JB, Chang J
PloS one 2016;11(6):e0157015
PloS one 2016;11(6):e0157015
Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma.
Penny HL, Sieow JL, Adriani G, Yeap WH, See Chi Ee P, San Luis B, Lee B, Lee T, Mak SY, Ho YS, Lam KP, Ong CK, Huang RY, Ginhoux F, Rotzschke O, Kamm RD, Wong SC
Oncoimmunology 2016 Aug;5(8):e1191731
Oncoimmunology 2016 Aug;5(8):e1191731
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis.
Hirota K, Hashimoto M, Yoshitomi H, Tanaka S, Nomura T, Yamaguchi T, Iwakura Y, Sakaguchi N, Sakaguchi S
The Journal of experimental medicine 2007 Jan 22;204(1):41-7
The Journal of experimental medicine 2007 Jan 22;204(1):41-7
Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation.
Anscher MS, Thrasher B, Rabbani Z, Teicher B, Vujaskovic Z
International journal of radiation oncology, biology, physics 2006 Jul 1;65(3):876-81
International journal of radiation oncology, biology, physics 2006 Jul 1;65(3):876-81
Cyclosporine induces cancer progression by a cell-autonomous mechanism.
Hojo M, Morimoto T, Maluccio M, Asano T, Morimoto K, Lagman M, Shimbo T, Suthanthiran M
Nature 1999 Feb 11;397(6719):530-4
Nature 1999 Feb 11;397(6719):530-4
Increased renal tubular expression of transforming growth factor beta in human allografts correlates with cyclosporine toxicity.
Pankewycz OG, Miao L, Isaacs R, Guan J, Pruett T, Haussmann G, Sturgill BC
Kidney international 1996 Nov;50(5):1634-40
Kidney international 1996 Nov;50(5):1634-40
Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification.
Dasch JR, Pace DR, Waegell W, Inenaga D, Ellingsworth L
Journal of immunology (Baltimore, Md. : 1950) 1989 Mar 1;142(5):1536-41
Journal of immunology (Baltimore, Md. : 1950) 1989 Mar 1;142(5):1536-41
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- Invitrogen Antibodies (provider)
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- Submitted by
- Invitrogen Antibodies (provider)
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- Experimental details
- FIGURE 2 Ets1 upregulation in glioblastoma endothelial cells depend on TGFbeta signaling. (A) RNA levels of Ets1 in bEND.3 cells treated with VEGFA, TNFalpha or TGFbeta (mean + SD of four independent experiments; ** p < 0.01; ANOVA with Tukey's multiple comparisons test). (B) RNA levels of Ets1 in bEND.3 cells treated with conditioned medium from CT-2A glioma cells with TGFbeta neutralizing antibody or control antibody (mean + SD of four independent experiments; ** p < 0.01; One-way ANOVA with Tukey's multiple comparisons test). (C) Immunohistochemical staining and quantification of Ets1 in CT-2A glioma tumor-bearing mice treated with/without galunisertib (bar: 50 mum) ( n = 10/group, Mann-Whitney test, * p < 0.05).
