AFDN

This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized. [provided by RefSeq, May 2011]

Description

afadin, adherens junction formation factor

Protein family

Cancer-related genes, Disease related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas), RAS pathway related proteins

Chromosome

6:q27 (167826922 - 167972023)

Ensembl ID

ENSG00000130396  (ver. 98.38)

Orthologs

Mouse Afdn: ENSMUSG00000068036

UniProt

P55196

neXtProt

NX_P55196

Human splice variants
Mouse splice variants