Antibody data

Product number
BS7963
Provider
Bioworld Technology, Inc
Product name
IRAK4 polyclonal antibody
Provider product page
Bioworld Technology, Inc - BS7963
Antibody type
Polyclonal
Antigen
Recombinant full length Human IRAK4.
Description
Interleukin-1 receptor (IL1R)-associated kinases (IRAKs) are important mediators in the signal transduction of Toll-like receptor (TLR) and IL1R family members, collectively referred to as TIRs. IRAK family members include two active kinases, IRAK-1 and IRAK-4, and two inactive kinase, IRAK-2 and IRAK-M. Binding of IL-1 to its cognate receptor results in the activation of the NFkB signaling pathway and MAP kinase pathways. IRAK-4 appears to act upstream of other IRAKs and phosphorylates IRAK-1 on threonine 387. It is highly expressed in liver and kidney tissues, but also displays a wide, low level of expression in other tissues. IRAK-4 is an essential component of innate immunity. Deficiency of IRAK-4 leads to recurrent bacterial infections and profound hyporesponsiveness to LPS and IL-1. Therefore, IRAK-4 may be a potential target for therapeutic drug design.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Provider Type Product Number
- No reagents -