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Protein structure
GPI
Glucose-6-phosphate isomeraseAMF, NLK
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Top validated antibodies |
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| Atlas Antibodies |  HPA024305 |
1 references | Polyclonal |
WB
ICC
IHC
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| Proteintech Group | 15171-1-AP |
13 references | Polyclonal |
WB
EL
ICC
IHC
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| NSJ Bioreagents | V7817 |
Monoclonal |
WB
ICC
IHC
PA
OA
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| Invitrogen Antibodies | 15171-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
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| Novus Biologicals | NBP1-47523 |
2 references | Monoclonal |
WB
EL
ICC
IHC
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