Tissue expression
Cell line expression
Protein structure
FEN1
Flap structure-specific endonuclease 1FEN-1, MF1, RAD2
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Proteintech Group | 14768-1-AP | 11 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
GeneTex | GTX101777 | 1 references | Polyclonal |
WB
ICC
IP
IHC
PLA
|
|
Invitrogen Antibodies | 14768-1-AP | Polyclonal |
WB
ICC
IP
IHC
OA
|
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NSJ Bioreagents | RQ5695 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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Novus Biologicals | NB100-321 | 6 references | Polyclonal |
WB
IP
IHC
|
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Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider