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Protein structure
PSMA7
Proteasome 20S subunit alpha 7C6, HSPC, RC6-1, XAPC7
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]
Top validated antibodies |
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| Proteintech Group |  15219-1-AP |
10 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Novus Biologicals | H00005688-M01 |
3 references | Monoclonal |
WB
EL
ICC
IP
IHC
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| Abnova Corporation | H00005688-M01 |
2 references | Monoclonal |
WB
EL
ICC
IP
IHC
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| antibodies-online | ABIN562474 |
2 references | Monoclonal |
WB
EL
ICC
IP
IHC
|
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| Invitrogen Antibodies | 15219-1-AP |
Polyclonal |
WB
ICC
IP
IHC
FC
OA
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