GRM1

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Description

Glutamate metabotropic receptor 1

Tissue specificity

Tissue enriched (brain)

Subcell location

Vesicles

Predicted location

Membrane

Protein family

Disease related genes
G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Potential drug targets
Predicted membrane proteins
Transporters

Chromosome

6 (146027646 - 146437601)

Ensembl ID

ENSG00000152822  (ver. 103.38)

Orthologs

Mouse Grm1: ENSMUSG00000019828

UniProt

Q13255

neXtProt

NX_Q13255

Human splice variants
Mouse splice variants

Protein structure