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Protein structure
INS
InsulinIDDM1, IDDM2
This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq, May 2020]
Top validated antibodies |
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| Proteintech Group |  15848-1-AP |
68 references | Polyclonal |
WB
EL
ICC
IHC
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| Novus Biologicals | NBP2-34738-0.1 mg |
Monoclonal |
WB
EL
ICC
IP
IHC
FC
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| Invitrogen Antibodies | AHB0052 |
78 references | Polyclonal |
WB
EL
IHC
BN
OA
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| GeneTex | GTX80204 |
1 references | Monoclonal |
EL
ICC
IHC
RA
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| OriGene | AM33363PU-S |
Monoclonal |
WB
ICC
IP
IHC
FC
|
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